Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 2100
Gene Symbol: ESR2
ESR2
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.600 Therapeutic CTD_human "c-erbB-2 and the ""triple-state"" in early breast carcinomas." 19548127

2010

Entrez Id: 2100
Gene Symbol: ESR2
ESR2
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.600 Biomarker CTD_human "c-erbB-2 and the ""triple-state"" in early breast carcinomas." 19548127

2010

Entrez Id: 2100
Gene Symbol: ESR2
ESR2
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.600 Biomarker BEFREE Estrogen receptor beta in the breast: role in estrogen responsiveness and development of breast cancer. 11162931

2000

Entrez Id: 2100
Gene Symbol: ESR2
ESR2
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.600 Biomarker BEFREE Estrogen receptor beta inhibits human breast cancer cell proliferation and tumor formation by causing a G2 cell cycle arrest. 14729654

2004

Entrez Id: 2100
Gene Symbol: ESR2
ESR2
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.600 Biomarker BEFREE Estrogen receptor beta and breast cancer. 15522549

2004

Entrez Id: 2100
Gene Symbol: ESR2
ESR2
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.600 Biomarker BEFREE Estrogen receptor-beta regulates psoriasin (S100A7) in human breast cancer. 17009105

2007

Entrez Id: 2100
Gene Symbol: ESR2
ESR2
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.600 Biomarker BEFREE Estrogen receptor beta inhibits angiogenesis and growth of T47D breast cancer xenografts. 17145865

2006

Entrez Id: 2100
Gene Symbol: ESR2
ESR2
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.600 Biomarker BEFREE Estrogen receptor-beta: why may it influence clinical outcome in estrogen receptor-alpha positive breast cancer? 17617929

2007

Entrez Id: 2100
Gene Symbol: ESR2
ESR2
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.600 AlteredExpression BEFREE Estrogen receptor-beta mRNA is associated with adverse outcome in patients with breast cancer. 19738412

2009

Entrez Id: 2100
Gene Symbol: ESR2
ESR2
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.600 AlteredExpression BEFREE Estrogen receptor beta is overexpressed in around 70% breast cancer cases, referrd to as "ER positive". 20067880

2009

Entrez Id: 2100
Gene Symbol: ESR2
ESR2
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.600 AlteredExpression BEFREE Estrogen receptor {beta}1 expression is regulated by miR-92 in breast cancer. 20484043

2010

Entrez Id: 2100
Gene Symbol: ESR2
ESR2
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.600 Biomarker BEFREE ERβ is considered to have a protective role in breast cancer development based on findings demonstrating that ERβ expression inhibits ERα-mediated proliferation of breast cancer cells. 21120602

2011

Entrez Id: 2100
Gene Symbol: ESR2
ESR2
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.600 Biomarker BEFREE ERβ isoform 5 (ERβ5) has been positively correlated with better prognosis and longer survival of patients with breast cancer (BCa) in various clinical studies. 24339738

2013

Entrez Id: 2100
Gene Symbol: ESR2
ESR2
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.600 Biomarker BEFREE Estrogen receptor beta-mediated proliferative inhibition and apoptosis in human breast cancer by calycosin and formononetin. 24355881

2013

Entrez Id: 2100
Gene Symbol: ESR2
ESR2
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.600 Biomarker BEFREE Estrogen receptor beta as a novel target of androgen receptor action in breast cancer cell lines. 24552459

2014

Entrez Id: 2100
Gene Symbol: ESR2
ESR2
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.600 Biomarker BEFREE Estrogen Receptor β as a Therapeutic Target in Breast Cancer Stem Cells. 28376210

2017

Entrez Id: 2100
Gene Symbol: ESR2
ESR2
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.600 Biomarker BEFREE Estrogen receptor beta (ERβ) is endowed with oncosuppressive activities, antagonizing hormone-induced carcinogenesis and inhibiting growth and oncogenic functions in luminal-like breast cancers (BCs), where its expression correlates with a better prognosis of the disease. 29017520

2017

Entrez Id: 2100
Gene Symbol: ESR2
ESR2
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.600 Biomarker BEFREE Estrogen receptor β (ERβ) has recently been identified as a pharmaceutical target in hormone replacement therapy for breast cancers. 29610818

2018

Entrez Id: 2100
Gene Symbol: ESR2
ESR2
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.600 Biomarker BEFREE ERβ alters the chemosensitivity of luminal breast cancer cells by regulating p53 function. 29854295

2018

Entrez Id: 2100
Gene Symbol: ESR2
ESR2
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.600 Biomarker BEFREE ERβ protein was shown to be abundant in the majority of normal breast epithelial cells and is present in 20-30% of breast cancers. 31571071

2020

Entrez Id: 2100
Gene Symbol: ESR2
ESR2
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.600 Biomarker BEFREE A great hallmark of breast cancer is the absence or presence of estrogen receptors ERα and ERβ, with a dominant role in cell proliferation, differentiation and cancer progression. 31401293

2020

Entrez Id: 2100
Gene Symbol: ESR2
ESR2
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.600 AlteredExpression BEFREE A second estrogen receptor, ERβ, has been found to be expressed in 50% to 90% of ERα-negative breast cancers, and ERβ expression in TNBCs has been shown to correlate with improved disease-free survival and good prognosis. 23979844

2013

Entrez Id: 2100
Gene Symbol: ESR2
ESR2
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.600 Biomarker BEFREE After adjusting for multiple-testing, our findings suggest that ESR2_CA is associated with breast cancer risk in Nigerian women, whereas ESR1_TA and AR_CAG seem to have no association with the disease among African American or Nigerian women. 22792352

2012

Entrez Id: 2100
Gene Symbol: ESR2
ESR2
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.600 AlteredExpression BEFREE AKT regulation of estrogen receptor beta transcriptional activity in breast cancer. 16951146

2006

Entrez Id: 2100
Gene Symbol: ESR2
ESR2
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.600 Biomarker BEFREE Altogether, this preliminary report indicates that the ERβ/RIP140 signaling is altered in unifocal breast cancers and correlated with patient outcome. 30669416

2019