×
Entrez Id:
672
Gene Symbol:
BRCA1
BRCA1
Hereditary Breast and Ovarian Cancer Syndrome
0.800
GeneticVariation
CLINVAR
BRCA1 sequence analysis in women at high risk for susceptibility mutations. Risk factor analysis and implications for genetic testing.
9333265
1997
×
Entrez Id:
672
Gene Symbol:
BRCA1
BRCA1
Hereditary Breast and Ovarian Cancer Syndrome
0.800
CausalMutation
CLINVAR
G1738R is a BRCA1 founder mutation in Greek breast/ovarian cancer patients: evaluation of its pathogenicity and inferences on its genealogical history.
17902052
2008
×
Entrez Id:
675
Gene Symbol:
BRCA2
BRCA2
Hereditary Breast and Ovarian Cancer Syndrome
0.800
CausalMutation
CLINVAR
High prevalence of BRCA1 deletions in BRCAPRO-positive patients with high carrier probability.
17591842
2007
×
Entrez Id:
675
Gene Symbol:
BRCA2
BRCA2
Hereditary Breast and Ovarian Cancer Syndrome
0.800
CausalMutation
CLINVAR
Multi-gene panel testing for hereditary cancer predisposition in unsolved high-risk breast and ovarian cancer patients.
28281021
2017
×
Entrez Id:
675
Gene Symbol:
BRCA2
BRCA2
Hereditary Breast and Ovarian Cancer Syndrome
0.800
GeneticVariation
CLINVAR
Assessment of functional effects of unclassified genetic variants.
18951449
2008
×
Entrez Id:
672
Gene Symbol:
BRCA1
BRCA1
Hereditary Breast and Ovarian Cancer Syndrome
0.800
CausalMutation
CLINVAR
A high incidence of BRCA1 mutations in 20 breast-ovarian cancer families.
8554067
1996
×
Entrez Id:
672
Gene Symbol:
BRCA1
BRCA1
Hereditary Breast and Ovarian Cancer Syndrome
0.800
CausalMutation
CLINVAR
A systematic genetic assessment of 1,433 sequence variants of unknown clinical significance in the BRCA1 and BRCA2 breast cancer-predisposition genes.
17924331
2007
×
Entrez Id:
672
Gene Symbol:
BRCA1
BRCA1
Hereditary Breast and Ovarian Cancer Syndrome
0.800
CausalMutation
CLINVAR
Mutations and polymorphic BRCA variants transmission in breast cancer familial members.
20352487
2011
×
Entrez Id:
672
Gene Symbol:
BRCA1
BRCA1
Hereditary Breast and Ovarian Cancer Syndrome
0.800
CausalMutation
CLINVAR
A biochemical analysis demonstrates that the BRCA1 intronic variant IVS10-2A--> C is a mutation.
14513821
2003
×
Entrez Id:
675
Gene Symbol:
BRCA2
BRCA2
Hereditary Breast and Ovarian Cancer Syndrome
0.800
CausalMutation
CLINVAR
Hepatoblastoma in a 4-year-old girl with Fanconi anaemia.
21138478
2011
×
Entrez Id:
675
Gene Symbol:
BRCA2
BRCA2
Hereditary Breast and Ovarian Cancer Syndrome
0.800
CausalMutation
CLINVAR
Increased risk of male cancer and identification of a potential prostate cancer cluster region in BRCA2.
26360800
2016
×
Entrez Id:
672
Gene Symbol:
BRCA1
BRCA1
Hereditary Breast and Ovarian Cancer Syndrome
0.800
CausalMutation
CLINVAR
BRCA1 and BRCA2 mutation analysis in breast-ovarian cancer families from northeastern Poland.
12673801
2003
×
Entrez Id:
672
Gene Symbol:
BRCA1
BRCA1
Hereditary Breast and Ovarian Cancer Syndrome
0.800
CausalMutation
CLINVAR
Multimodal assessment of protein functional deficiency supports pathogenicity of BRCA1 p.V1688del.
19706752
2009
×
Entrez Id:
675
Gene Symbol:
BRCA2
BRCA2
Hereditary Breast and Ovarian Cancer Syndrome
0.800
GeneticVariation
CLINVAR
A systematic genetic assessment of 1,433 sequence variants of unknown clinical significance in the BRCA1 and BRCA2 breast cancer-predisposition genes.
17924331
2007
×
Entrez Id:
675
Gene Symbol:
BRCA2
BRCA2
Hereditary Breast and Ovarian Cancer Syndrome
0.800
CausalMutation
CLINVAR
Clinical and pathological characteristics of Hispanic BRCA-associated breast cancers in the American-Mexican border city of El Paso, TX.
25628955
2015
×
Entrez Id:
675
Gene Symbol:
BRCA2
BRCA2
Hereditary Breast and Ovarian Cancer Syndrome
0.800
CausalMutation
CLINVAR
Pyrimidine base damage is increased in women with BRCA mutations.
23583677
2013
×
Entrez Id:
675
Gene Symbol:
BRCA2
BRCA2
Hereditary Breast and Ovarian Cancer Syndrome
0.800
GeneticVariation
CLINVAR
A high-throughput protocol for mutation scanning of the BRCA1 and BRCA2 genes.
21702907
2011
×
Entrez Id:
672
Gene Symbol:
BRCA1
BRCA1
Hereditary Breast and Ovarian Cancer Syndrome
0.800
CausalMutation
CLINVAR
Double heterozygosity for mutations in BRCA1 and BRCA2 in German breast cancer patients: implications on test strategies and clinical management.
22535016
2012
×
Entrez Id:
675
Gene Symbol:
BRCA2
BRCA2
Hereditary Breast and Ovarian Cancer Syndrome
0.800
GeneticVariation
CLINVAR
The role of targeted BRCA1/BRCA2 mutation analysis in hereditary breast/ovarian cancer families of Portuguese ancestry.
24916970
2015
×
Entrez Id:
675
Gene Symbol:
BRCA2
BRCA2
Hereditary Breast and Ovarian Cancer Syndrome
0.800
GeneticVariation
CLINVAR
A comprehensive functional characterization of BRCA2 variants associated with Fanconi anemia using mouse ES cell-based assay.
21719596
2011
×
Entrez Id:
675
Gene Symbol:
BRCA2
BRCA2
Hereditary Breast and Ovarian Cancer Syndrome
0.800
CausalMutation
CLINVAR
Functional analysis of a large set of BRCA2 exon 7 variants highlights the predictive value of hexamer scores in detecting alterations of exonic splicing regulatory elements.
23983145
2013
×
Entrez Id:
672
Gene Symbol:
BRCA1
BRCA1
Hereditary Breast and Ovarian Cancer Syndrome
0.800
GeneticVariation
CLINVAR
Two Missense Mutations in the Primary Autosomal Recessive Microcephaly Gene MCPH1 Disrupt the Function of the Highly Conserved N-Terminal BRCT Domain of Microcephalin.
22855649
2012
×
Entrez Id:
675
Gene Symbol:
BRCA2
BRCA2
Hereditary Breast and Ovarian Cancer Syndrome
0.800
CausalMutation
CLINVAR
Genetic and histopathologic evaluation of BRCA1 and BRCA2 DNA sequence variants of unknown clinical significance.
16489001
2006
×
Entrez Id:
672
Gene Symbol:
BRCA1
BRCA1
Hereditary Breast and Ovarian Cancer Syndrome
0.800
CausalMutation
CLINVAR
A specific GFP expression assay, penetrance estimate, and histological assessment for a putative splice site mutation in BRCA1.
12815598
2003
×
Entrez Id:
675
Gene Symbol:
BRCA2
BRCA2
Hereditary Breast and Ovarian Cancer Syndrome
0.800
CausalMutation
CLINVAR
Evaluation of unclassified variants in the breast cancer susceptibility genes BRCA1 and BRCA2 using five methods: results from a population-based study of young breast cancer patients.
18284688
2008