Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 367
Gene Symbol: AR
AR
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
1.000 GeneticVariation UNIPROT

Entrez Id: 367
Gene Symbol: AR
AR
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
1.000 CausalMutation CLINVAR

Entrez Id: 367
Gene Symbol: AR
AR
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
1.000 GeneticVariation CLINVAR

Entrez Id: 367
Gene Symbol: AR
AR
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
1.000 Biomarker GENOMICS_ENGLAND

Entrez Id: 367
Gene Symbol: AR
AR
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
1.000 Biomarker HPO

Entrez Id: 367
Gene Symbol: AR
AR
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
1.000 GeneticVariation BEFREE Androgen receptor gene mutations in human prostate cancer. 1631125

1992

Entrez Id: 367
Gene Symbol: AR
AR
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
1.000 Biomarker BEFREE (2) The c-erb B-2/neu protein was detected in both androgen-receptor-positive (LNCaP) and -negative (PC-3 and DU-145) human prostate cancer cell lines. 1353965

1992

Entrez Id: 367
Gene Symbol: AR
AR
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
1.000 GeneticVariation BEFREE These results suggest that androgen receptor mutations are probably uncommon molecular events in the early stages of prostatic cancer. 8426836

1993

Entrez Id: 367
Gene Symbol: AR
AR
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
1.000 GeneticVariation BEFREE Androgen receptor gene mutations in human prostate cancer. 8274409

1993

Entrez Id: 367
Gene Symbol: AR
AR
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
1.000 Biomarker BEFREE Androgen-induced inhibition of cell proliferation in an androgen-insensitive prostate cancer cell line (PC-3) transfected with a human androgen receptor complementary DNA. 8443809

1993

Entrez Id: 367
Gene Symbol: AR
AR
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
1.000 AlteredExpression BEFREE Increased androgen receptor activity and altered c-myc expression in prostate cancer cells after long-term androgen deprivation. 7511045

1994

Entrez Id: 367
Gene Symbol: AR
AR
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
1.000 GeneticVariation BEFREE Microsatellite mutation (CAG24-->18) in the androgen receptor gene in human prostate cancer. 8292051

1994

Entrez Id: 367
Gene Symbol: AR
AR
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
1.000 Biomarker BEFREE Evidence coming from studies on AR in prostatic cancer highlights the possibility that AR structural alterations may have significance in tumor progression. 7971517

1994

Entrez Id: 367
Gene Symbol: AR
AR
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
1.000 GeneticVariation BEFREE It is possible that analogous to an activated/altered growth factor receptor oncogene, codon 877 mutant AR with altered ligand binding may provide a selective growth advantage in the genesis of a subset of advanced prostate cancer. 8187068

1994

Entrez Id: 367
Gene Symbol: AR
AR
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
1.000 Biomarker BEFREE Androgen receptor status in localized and locally progressive hormone refractory human prostate cancer. 7512791

1994

Entrez Id: 367
Gene Symbol: AR
AR
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
1.000 GeneticVariation BEFREE The CAG and GGC microsatellites of the androgen receptor gene are in linkage disequilibrium in men with prostate cancer. 7728763

1995

Entrez Id: 367
Gene Symbol: AR
AR
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
1.000 GeneticVariation BEFREE Androgen receptor gene mutations in prostate cancer are very rare and are reported only in exons 4-8. 7626493

1995

Entrez Id: 367
Gene Symbol: AR
AR
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
1.000 GeneticVariation BEFREE Mutated human androgen receptor gene detected in a prostatic cancer patient is also activated by estradiol. 8530589

1995

Entrez Id: 367
Gene Symbol: AR
AR
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
1.000 Biomarker BEFREE We analyzed the androgen-receptor genes from samples of metastatic androgen-independent prostate cancers to determine whether mutations in the gene have a role in androgen independence. 7723794

1995

Entrez Id: 367
Gene Symbol: AR
AR
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
1.000 Biomarker BEFREE We have identified a similar molecular mechanism in vivo for endocrine treatment failure in human prostate cancer which involves amplification of the androgen receptor (AR) gene. 7795646

1995

Entrez Id: 367
Gene Symbol: AR
AR
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
1.000 AlteredExpression BEFREE In other cases, altered androgen receptor activity due to its mutation or altered expression may lead to pathology such as recurrence of prostate cancer due to development of androgen independence allowing tumor cell proliferation under androgen deprivation. 9159212

1996

Entrez Id: 367
Gene Symbol: AR
AR
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
1.000 GeneticVariation BEFREE These data indicate that AR gene mutations occur commonly in advanced prostate cancers prior to endocrine treatment of disease and may contribute to altered androgen responsiveness of the tumors. 9816170

1996

Entrez Id: 367
Gene Symbol: AR
AR
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
1.000 AlteredExpression BEFREE Here we shown that androgen promoted up-regulation of AR mRNA in two androgen-independent human prostate cancer cell lines, PC3 and DU145, when each was transfected with a human AR cDNA. 8883219

1996

Entrez Id: 367
Gene Symbol: AR
AR
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
1.000 Biomarker BEFREE To further investigate structural abnormality of the AR in a large number of human prostate cancers, exons B-H encoding DNA-and hormone-binding domains were examined by single-strand conformation polymorphism analysis of polymerase chain reaction products and direct sequencing. 8827083

1996

Entrez Id: 367
Gene Symbol: AR
AR
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
1.000 GeneticVariation BEFREE It could be speculated that this specific mutant androgen receptor provides a selective growth advantage in a subset of advanced prostate cancers. 8717468

1996