Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 154091
Gene Symbol: SLC2A12
SLC2A12
Diabetes Mellitus, Non-Insulin-Dependent
0.010 AlteredExpression BEFREE The exogenous administration of adiponectin to T2D mice showed enhanced serum testosterone and expression of testicular steroidogenic markers proteins, insulin receptor and GLUT8 proteins, increase in intra-testicular concentrations of glucose and lactate and activity of LDH and antioxidant enzymes compared to the levels in untreated T2D mice. 31676315

2020

Entrez Id: 7150
Gene Symbol: TOP1
TOP1
Diabetes Mellitus, Non-Insulin-Dependent
0.010 Biomarker BEFREE Titration of insulin glargine 100 U/mL when added to oral antidiabetic drugs in patients with type 2 diabetes: results of the TOP-1 real-world study. 31342163

2020

Entrez Id: 24145
Gene Symbol: PANX1
PANX1
Diabetes Mellitus, Non-Insulin-Dependent
0.010 Biomarker BEFREE Our findings reveal an insulin-pannexin-1-purinergic signalling crosstalk in adipose tissue and we propose that deregulation of this signalling may contribute to adipose tissue inflammation and type 2 diabetes. 31400255

2020

Entrez Id: 3562
Gene Symbol: IL3
IL3
Diabetes Mellitus, Non-Insulin-Dependent
0.010 AlteredExpression BEFREE The levels of IL-3 and INF- γ were significantly higher in type II diabetes mellitus, while GABA serum levels were higher in type I diabetes mellitus. 31014937

2020

Entrez Id: 83881
Gene Symbol: MIXL1
MIXL1
Diabetes Mellitus, Non-Insulin-Dependent
0.010 Biomarker BEFREE A total of 170 patients with type 2 diabetes who underwent kidney biopsies were included and divided into three groups according to pathological findings: DN group (n = 46), MIX group (DN + NDRD, n = 54), NDRD group (n = 70). 31602779

2020

Entrez Id: 9270
Gene Symbol: ITGB1BP1
ITGB1BP1
Diabetes Mellitus, Non-Insulin-Dependent
0.010 AlteredExpression BEFREE Interestingly, expression of collagen type I, integrin beta-I binding protein-I, pyruvate dehydrogenase kinase, TNF receptor genes up-regulated with DM; on the other hand, IL-33, cholecystokinin, plasminogen activator, IL-1 and serine peptidase inhibitor genes down-regulated significantly. 31424965

2020

Entrez Id: 2634
Gene Symbol: GBP2
GBP2
Diabetes Mellitus, Non-Insulin-Dependent
0.010 Biomarker BEFREE Based on published estimates of the proportion of type 2 diabetes patients failing to meet glycemic targets in the UK, this corresponds to an additional economic burden of ∼GBP 2,600 million (complication costs plus lost productivity costs).<b>Conclusions:</b> The economic burden of poor glycemic control in type 2 diabetes in the UK is substantial. 31311364

2020

Entrez Id: 55068
Gene Symbol: ENOX1
ENOX1
Diabetes Mellitus, Non-Insulin-Dependent
0.010 AlteredExpression BEFREE Different retinal ENOX1 expression in T2D mice and control mice suggested that ENOX1 may be involved in DR development. 31662505

2020

Entrez Id: 80168
Gene Symbol: MOGAT2
MOGAT2
Diabetes Mellitus, Non-Insulin-Dependent
0.010 Biomarker BEFREE Here, we further investigate the effects of MGAT2 inhibition on 1) fat-induced gut peptide release and fat intake in normal mice and 2) metabolic disorders in high-fat diet (HFD)-fed ob/ob mice, a model of severe obesity and type 2 diabetes mellitus, using an orally bioavailable MGAT2 inhibitor Compound B (CpdB). 31837122

2020

Entrez Id: 1400
Gene Symbol: CRMP1
CRMP1
Diabetes Mellitus, Non-Insulin-Dependent
0.010 Biomarker BEFREE PRACTICAL APPLICATIONS: Mfn2 and Drp1, as the main regulators of the mitochondrial fusion and fission, play an important role in maintaining mitochondrial dynamics and type 2 diabetes. 31849103

2020

Entrez Id: 3487
Gene Symbol: IGFBP4
IGFBP4
Diabetes Mellitus, Non-Insulin-Dependent
0.010 Biomarker BEFREE To study the role of PAPP-A and the IGF system in diabetic polyneuropathy (DPN), we measured immunoreactive (total) concentrations of IGF-I and IGF-II, bioactive IGF by cell-based bioassay, PAPP-A, as well as intact and PAPP-A-cleaved IGFBP-4 in cerebrospinal fluid (CSF) and serum from patients with type 2 diabetes (T2D) with and without DPN. 31670029

2020

Entrez Id: 29988
Gene Symbol: SLC2A8
SLC2A8
Diabetes Mellitus, Non-Insulin-Dependent
0.010 AlteredExpression BEFREE The exogenous administration of adiponectin to T2D mice showed enhanced serum testosterone and expression of testicular steroidogenic markers proteins, insulin receptor and GLUT8 proteins, increase in intra-testicular concentrations of glucose and lactate and activity of LDH and antioxidant enzymes compared to the levels in untreated T2D mice. 31676315

2020

Entrez Id: 6717
Gene Symbol: SRI
SRI
Diabetes Mellitus, Non-Insulin-Dependent
0.010 Biomarker BEFREE We collected SDA, SRI and Epworth Sleepiness Scale (ESS) before and after initiation of positive airway pressure (PAP) in patients with type 2 diabetes newly diagnosed with OSA. 31785255

2020

Entrez Id: 192
Gene Symbol: AIC
AIC
Diabetes Mellitus, Non-Insulin-Dependent
0.010 Biomarker BEFREE Meta-analysis results showed that culturally tailored DSME interventions significantly reduce AIC in Latinos with T2DM despite the heterogeneity across the studies. 31542186

2020

Entrez Id: 79924
Gene Symbol: ADM2
ADM2
Diabetes Mellitus, Non-Insulin-Dependent
0.010 AlteredExpression BEFREE We measured metabolic parameters, serum AM2 and expression of ADM2 and its receptor component genes in abdominal subcutaneous and visceral adipose tissue in obese (with or without type 2 diabetes) and normal-weight women. 31642491

2020

Entrez Id: 9159
Gene Symbol: PCSK7
PCSK7
Diabetes Mellitus, Non-Insulin-Dependent
0.010 GeneticVariation BEFREE Conversely, serine, glutamine and LPC C18:2 decreased risk of T2D. 31782507

2020

Entrez Id: 7402
Gene Symbol: UTRN
UTRN
Diabetes Mellitus, Non-Insulin-Dependent
0.010 Biomarker BEFREE PRACTICAL APPLICATIONS: Mfn2 and Drp1, as the main regulators of the mitochondrial fusion and fission, play an important role in maintaining mitochondrial dynamics and type 2 diabetes. 31849103

2020

Entrez Id: 5345
Gene Symbol: SERPINF2
SERPINF2
Diabetes Mellitus, Non-Insulin-Dependent
0.010 Biomarker BEFREE We investigated α2-antiplasmin incorporation into fibrin clots as a determinant of clot lysability in patients of both sexes with T2DM. 31770688

2020

Entrez Id: 7060
Gene Symbol: THBS4
THBS4
Diabetes Mellitus, Non-Insulin-Dependent
0.010 AlteredExpression BEFREE Interestingly, TSP-4 levels were higher in patients with type 2 diabetes mellitus or prediabetes (DGT) compared with normal glucose tolerance (NGT) (4.76 ± 0.42 vs. 4.66 ± 0.41, p = 0.035). 31227875

2020

Entrez Id: 23604
Gene Symbol: DAPK2
DAPK2
Diabetes Mellitus, Non-Insulin-Dependent
0.010 Biomarker BEFREE PRACTICAL APPLICATIONS: Mfn2 and Drp1, as the main regulators of the mitochondrial fusion and fission, play an important role in maintaining mitochondrial dynamics and type 2 diabetes. 31849103

2020

Entrez Id: 8562
Gene Symbol: DENR
DENR
Diabetes Mellitus, Non-Insulin-Dependent
0.010 Biomarker BEFREE PRACTICAL APPLICATIONS: Mfn2 and Drp1, as the main regulators of the mitochondrial fusion and fission, play an important role in maintaining mitochondrial dynamics and type 2 diabetes. 31849103

2020

Entrez Id: 2810
Gene Symbol: SFN
SFN
Diabetes Mellitus, Non-Insulin-Dependent
0.010 AlteredExpression BEFREE We recently published that type 2 diabetes promotes cell centrosome amplification via upregulation of Rho-associated protein kinase 1 (ROCK1) and 14-3-3 protein-σ (14-3-3σ). 31618077

2020

Entrez Id: 10497
Gene Symbol: UNC13B
UNC13B
Diabetes Mellitus, Non-Insulin-Dependent
0.010 GeneticVariation BEFREE RESULTS There were no significant differences in the distribution of allele or genotype frequencies in the five UNC13B SNP markers (rs13293564, rs17360668, rs10114937, rs661712, and rs2281999) between the DKD group and control group of patients with T2DM. 31713534

2019

Entrez Id: 4830
Gene Symbol: NME1
NME1
Diabetes Mellitus, Non-Insulin-Dependent
0.010 Biomarker BEFREE Three leader genes (PSMD10, SOS1, WASF3), eight cross-talk genes (PSMD10, PSMD6, EIF2S1, GSTP1, DNAJC3, SEC61A1, MAPT, and NME1), and one signaling pathway (IL-17 signaling) emerged as peri-implantitis and T2DM linkage mechanisms. 31275749

2019

Entrez Id: 26292
Gene Symbol: MYCBP
MYCBP
Diabetes Mellitus, Non-Insulin-Dependent
0.010 Biomarker BEFREE Several studies recently reported contradicting results regarding the link between amylase 1 (AMY1) copy numbers (CNs), obesity, and type 2 diabetes. 30982860

2019