×
Entrez Id:
673
Gene Symbol:
BRAF
BRAF
melanoma
1.000
GeneticVariation
CLINVAR
Correlation of BRAF and NRAS mutation status with outcome, site of distant metastasis and response to chemotherapy in metastatic melanoma.
24918823
2014
×
Entrez Id:
673
Gene Symbol:
BRAF
BRAF
melanoma
1.000
GeneticVariation
CLINVAR
BRAF and NRAS mutations are heterogeneous and not mutually exclusive in nodular melanoma.
24710085
2015
×
Entrez Id:
673
Gene Symbol:
BRAF
BRAF
melanoma
1.000
GeneticVariation
CLINVAR
Frequency and spectrum of BRAF mutations in a retrospective, single-institution study of 1112 cases of melanoma.
23273605
2013
×
Entrez Id:
673
Gene Symbol:
BRAF
BRAF
melanoma
1.000
GeneticVariation
CLINVAR
Determinants of BRAF mutations in primary melanomas.
14679157
2003
×
Entrez Id:
673
Gene Symbol:
BRAF
BRAF
melanoma
1.000
GeneticVariation
CLINVAR
Mutational analysis of the BRAF gene in transitional cell carcinoma of the bladder.
19404918
2009
×
Entrez Id:
673
Gene Symbol:
BRAF
BRAF
melanoma
1.000
GeneticVariation
CLINVAR
Prospective enterprise-level molecular genotyping of a cohort of cancer patients.
25157968
2014
×
Entrez Id:
673
Gene Symbol:
BRAF
BRAF
melanoma
1.000
GeneticVariation
CLINVAR
Acute effects of some volatile nitrites on motor performance and lethality in mice.
2872605
1986
×
Entrez Id:
673
Gene Symbol:
BRAF
BRAF
melanoma
1.000
GeneticVariation
CLINVAR
Improved survival with MEK inhibition in BRAF-mutated melanoma.
22663011
2012
×
Entrez Id:
673
Gene Symbol:
BRAF
BRAF
melanoma
1.000
GeneticVariation
CLINVAR
Phase II study of the MEK1/MEK2 inhibitor Trametinib in patients with metastatic BRAF-mutant cutaneous melanoma previously treated with or without a BRAF inhibitor.
23248257
2013
×
Entrez Id:
673
Gene Symbol:
BRAF
BRAF
melanoma
1.000
GeneticVariation
CLINVAR
Vemurafenib produced improved rates of overall and progression-free survival in patients with previously untreated melanoma with the BRAF V600E mutation.
21639808
2011
×
Entrez Id:
673
Gene Symbol:
BRAF
BRAF
melanoma
1.000
GeneticVariation
CLINVAR
These results suggest that BRAF mutation in melanoma is most likely to occur prior to the development of metastatic disease.
16096377
2005
×
Entrez Id:
673
Gene Symbol:
BRAF
BRAF
melanoma
1.000
GeneticVariation
CLINVAR
Safety and efficacy of vemurafenib in BRAF(V600E) and BRAF(V600K) mutation-positive melanoma (BRIM-3): extended follow-up of a phase 3, randomised, open-label study.
24508103
2014
×
Entrez Id:
673
Gene Symbol:
BRAF
BRAF
melanoma
1.000
GeneticVariation
CLINVAR
Here we report BRAF somatic missense mutations in 66% of malignant melanomas and at lower frequency in a wide range of human cancers.
12068308
2002
×
Entrez Id:
673
Gene Symbol:
BRAF
BRAF
melanoma
1.000
GeneticVariation
CLINVAR
Phase II trial (BREAK-2) of the BRAF inhibitor dabrafenib (GSK2118436) in patients with metastatic melanoma.
23918947
2013
×
Entrez Id:
673
Gene Symbol:
BRAF
BRAF
melanoma
1.000
GeneticVariation
CLINVAR
Phase II, open-label, randomized trial of the MEK1/2 inhibitor selumetinib as monotherapy versus temozolomide in patients with advanced melanoma.
22048237
2012
×
Entrez Id:
673
Gene Symbol:
BRAF
BRAF
melanoma
1.000
GeneticVariation
CLINVAR
NRAS and BRAF mutation frequency in primary oral mucosal melanoma.
21750866
2011
×
Entrez Id:
673
Gene Symbol:
BRAF
BRAF
melanoma
1.000
GeneticVariation
CLINVAR
Overwhelming response to Dabrafenib in a patient with double BRAF mutation (V600E; V600M) metastatic malignant melanoma.
23031422
2012
×
Entrez Id:
673
Gene Symbol:
BRAF
BRAF
melanoma
1.000
GeneticVariation
CLINVAR
In summary, we have identified a group of melanomas with low-activity BRAF mutations that are reliant upon CRAF-mediated survival activity.
18794803
2009
×
Entrez Id:
673
Gene Symbol:
BRAF
BRAF
melanoma
1.000
GeneticVariation
CLINVAR
Clinical responses to selumetinib (AZD6244; ARRY-142886)-based combination therapy stratified by gene mutations in patients with metastatic melanoma.
22972589
2013
×
Entrez Id:
673
Gene Symbol:
BRAF
BRAF
melanoma
1.000
GeneticVariation
CLINVAR
Mutation analysis of BRAF, MEK1 and MEK2 in 15 ovarian cancer cell lines: implications for therapy.
18060073
2007
×
Entrez Id:
3265
Gene Symbol:
HRAS
HRAS
melanoma
0.800
GeneticVariation
CLINVAR
Prospective enterprise-level molecular genotyping of a cohort of cancer patients.
25157968
2014
×
Entrez Id:
1029
Gene Symbol:
CDKN2A
CDKN2A
melanoma
0.800
GeneticVariation
CLINVAR
Combination therapy with vemurafenib (PLX4032/RG7204) and metformin in melanoma cell lines with distinct driver mutations.
21609436
2011
×
Entrez Id:
1029
Gene Symbol:
CDKN2A
CDKN2A
melanoma
0.800
GeneticVariation
CLINVAR
Prospective enterprise-level molecular genotyping of a cohort of cancer patients.
25157968
2014
×
Entrez Id:
1019
Gene Symbol:
CDK4
CDK4
melanoma
0.700
GeneticVariation
CLINVAR
Prospective enterprise-level molecular genotyping of a cohort of cancer patients.
25157968
2014
×
Entrez Id:
5604
Gene Symbol:
MAP2K1
MAP2K1
melanoma
0.700
GeneticVariation
CLINVAR
Phase II trial of MEK inhibitor selumetinib (AZD6244, ARRY-142886) in patients with BRAFV600E/K-mutated melanoma.
23444215
2013