Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.600 GeneticVariation UNIPROT

Entrez Id: 5782
Gene Symbol: PTPN12
PTPN12
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.510 GeneticVariation UNIPROT

Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.470 GeneticVariation UNIPROT

Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 GeneticVariation UNIPROT

Entrez Id: 5795
Gene Symbol: PTPRJ
PTPRJ
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.350 GeneticVariation UNIPROT

Entrez Id: 8626
Gene Symbol: TP63
TP63
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.330 GeneticVariation UNIPROT

Entrez Id: 25788
Gene Symbol: RAD54B
RAD54B
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.320 GeneticVariation UNIPROT

Entrez Id: 5606
Gene Symbol: MAP2K3
MAP2K3
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.300 GeneticVariation UNIPROT

Entrez Id: 2520
Gene Symbol: GAST
GAST
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 Biomarker CTD_human The hyperplastic response of the fundic mucosa was increased by increasing gastrin doses; whereas, colon cancer hyperplasia was maximal at the lowest dose tested (125 micrograms/kg/day) and did not increase further with increasing doses of hormone. 3952654

1986

Entrez Id: 5782
Gene Symbol: PTPN12
PTPN12
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.510 Biomarker GENOMICS_ENGLAND Chromosomal localization of the protein tyrosine phosphatase G1 gene and characterization of the aberrant transcripts in human colon cancer cells. 7509295

1994

Entrez Id: 7048
Gene Symbol: TGFBR2
TGFBR2
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.500 Biomarker CTD_human Inactivation of the type II TGF-beta receptor in colon cancer cells with microsatellite instability. 7761852

1995

Entrez Id: 324
Gene Symbol: APC
APC
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.500 Biomarker CTD_human Specific 5'-GGGA-3'-->5'-GGA-3' mutation of the Apc gene in rat colon tumors induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine. 7846077

1995

Entrez Id: 3383
Gene Symbol: ICAM1
ICAM1
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.350 Biomarker CTD_human It remains to be clarified what part both forms of ICAM-1 play in the course of colonic cancer, ulcerative colitis, and Crohn's disease. 7902311

1993

Entrez Id: 324
Gene Symbol: APC
APC
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.500 Biomarker CTD_human Genetic alterations in rat colon tumors induced by heterocyclic amines. 8608549

1996

Entrez Id: 5020
Gene Symbol: OXT
OXT
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.300 Therapeutic CTD_human Oxytocin and oxytocin-analogue F314 inhibit cell proliferation and tumor growth of rat and mouse mammary carcinomas. 8647655

1996

Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 Biomarker CTD_human Activating mutations in the beta-catenin (CTNNB1) gene corresponding to N-terminal phosphorylation sites in the protein have been implicated in the development of human colon cancer. 9515794

1998

Entrez Id: 596
Gene Symbol: BCL2
BCL2
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.600 Biomarker CTD_human Relationship of beta-catenin and Bcl-2 expression to sulindac-induced regression of intestinal tumors in Min mice. 10223192

1999

Entrez Id: 324
Gene Symbol: APC
APC
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.500 Biomarker CTD_human Neonatal exposure to the food mutagen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine via breast milk or directly induces intestinal tumors in multiple intestinal neoplasia mice. 10383901

1999

Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.500 Biomarker CTD_human ras p21 Isoprenylation inhibition induces flat colon tumors in Wistar rats. 10813127

2000

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 Therapeutic CTD_human Regrowth of 5-fluorouracil-treated human colon cancer cells is prevented by the combination of interferon gamma, indomethacin, and phenylbutyrate. 10866311

2000

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 Biomarker CTD_human Increased ErbB-2 tyrosine kinase activity, MAPK phosphorylation, and cell proliferation in the prostate cancer cell line LNCaP following treatment by select pesticides. 11222871

2001

Entrez Id: 6513
Gene Symbol: SLC2A1
SLC2A1
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.380 Biomarker CTD_human Molecular changes in the expression of human colonic nutrient transporters during the transition from normality to malignancy. 11953883

2002

Entrez Id: 6566
Gene Symbol: SLC16A1
SLC16A1
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.300 Biomarker CTD_human Molecular changes in the expression of human colonic nutrient transporters during the transition from normality to malignancy. 11953883

2002

Entrez Id: 324
Gene Symbol: APC
APC
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.500 Biomarker CTD_human One dose of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) or 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) induces tumours in Min/+ mice by truncation mutations or LOH in the Apc gene. 12034317

2002

Entrez Id: 4057
Gene Symbol: LTF
LTF
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.310 Therapeutic CTD_human Down-regulation of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx)-induced CYP1A2 expression is associated with bovine lactoferrin inhibition of MeIQx-induced liver and colon carcinogenesis in rats. 12079509

2002