Source: ALL

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 260431
Gene Symbol: COPD
COPD
CUI: C0034067
Disease: Pulmonary Emphysema
Pulmonary Emphysema
0.100 Biomarker BEFREE "Severe mixed airway-emphysema" disease may predict COPD-associated mortality. 30174423

2018

Entrez Id: 260431
Gene Symbol: COPD
COPD
CUI: C0206062
Disease: Lung Diseases, Interstitial
Lung Diseases, Interstitial
0.100 GeneticVariation BEFREE <b>Backgroud and objectives:</b> Although lung attenuation distribution and lung volume on computed tomography (CT) have been widely used in evaluating COPD and interstitial lung disease, there are only a few studies regarding the normal range of these indices, especially in Chinese subjects. 31413560

2019

Entrez Id: 260431
Gene Symbol: COPD
COPD
CUI: C0024115
Disease: Lung diseases
Lung diseases
0.100 Biomarker BEFREE <b>Background:</b> COPD is a progressive lung disease characterized by emphysema and enhanced bronchoconstriction. 28101062

2016

Entrez Id: 260431
Gene Symbol: COPD
COPD
CUI: C0034067
Disease: Pulmonary Emphysema
Pulmonary Emphysema
0.100 Biomarker BEFREE <b>Background:</b> COPD is a progressive lung disease characterized by emphysema and enhanced bronchoconstriction. 28101062

2016

Entrez Id: 260431
Gene Symbol: COPD
COPD
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.100 GeneticVariation BEFREE <b>Conclusion:</b> 6MWD and EID exhibit different determinants in COPD with a minor impact of comorbidities limited to hypertension in EID and to obesity, which was unexpectedly associated with less EID. 31308646

2019

Entrez Id: 260431
Gene Symbol: COPD
COPD
CUI: C0028754
Disease: Obesity
Obesity
0.100 GeneticVariation BEFREE <b>Conclusion:</b> 6MWD and EID exhibit different determinants in COPD with a minor impact of comorbidities limited to hypertension in EID and to obesity, which was unexpectedly associated with less EID. 31308646

2019

Entrez Id: 260431
Gene Symbol: COPD
COPD
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.100 Biomarker BEFREE <b>Conclusion:</b> NSCLC patients with preexisting COPD had shorter survival with marked differences in early stages of lung cancer. 31118599

2019

Entrez Id: 260431
Gene Symbol: COPD
COPD
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung
0.100 Biomarker BEFREE <b>Conclusion:</b> NSCLC patients with preexisting COPD had shorter survival with marked differences in early stages of lung cancer. 31118599

2019

Entrez Id: 260431
Gene Symbol: COPD
COPD
CUI: C1306460
Disease: Primary malignant neoplasm of lung
Primary malignant neoplasm of lung
0.100 Biomarker BEFREE <b>Conclusion:</b> NSCLC patients with preexisting COPD had shorter survival with marked differences in early stages of lung cancer. 31118599

2019

Entrez Id: 260431
Gene Symbol: COPD
COPD
CUI: C0013404
Disease: Dyspnea
Dyspnea
0.100 Biomarker BEFREE <b>Conclusions:</b> This study suggests that patients with stable moderate-to-severe COPD show higher activation in emotion-related brain areas than healthy controls during the anticipation, but not during the actual perception of experimentally induced dyspnea. 28878693

2017

Entrez Id: 260431
Gene Symbol: COPD
COPD
Acute lower respiratory tract infection
0.010 Biomarker BEFREE <b>Introduction</b>: Neutrophils are the most abundant inflammatory cells in the lungs of patients with chronic lung diseases, especially COPD, yet despite this, patients often experience repeated chest infections. 31394045

2019

Entrez Id: 260431
Gene Symbol: COPD
COPD
CUI: C0034067
Disease: Pulmonary Emphysema
Pulmonary Emphysema
0.100 Biomarker BEFREE <b>Objective:</b> We investigated the impact of preexisting COPD and its subtypes, chronic bronchitis and emphysema, on overall survival among Medicare enrollees diagnosed with non-small-cell lung cancer (NSCLC). 31118599

2019

Entrez Id: 260431
Gene Symbol: COPD
COPD
CUI: C0024117
Disease: Chronic Obstructive Airway Disease
Chronic Obstructive Airway Disease
0.100 Biomarker BEFREE <b>Objectives:</b> The bronchodilator efficacy of a once-daily fixed-dose combination of tiotropium/formoterol (18/12 µg administered via a dry-powder inhaler, Discair) [TIO/FORM<sub>fixed</sub> group] vs a single-dose of tiotropium (18 µg) by Handihaler<sup>1</sup> alone [TIO<sub>mono</sub> group], or combined with formoterol 12 µg twice-daily by Aerolizer<sup>2</sup> [TIO/FORM<sub>bid</sub> group] was compared in patients with moderate-to-severe stable COPD.<b>Methods:</b> COPD patients were randomized (28 patients/group) to receive TIO/FORM<sub>fixed</sub>, TIO<sub>mono</sub><b> 31397184

2019

Entrez Id: 260431
Gene Symbol: COPD
COPD
CUI: C0600260
Disease: Lung Diseases, Obstructive
Lung Diseases, Obstructive
0.100 GeneticVariation BEFREE <b>Patients and methods:</b> The data of 18 patients with OLD (16 with COPD, two with asthma COPD overlap), 11 with ILD, and 24 healthy volunteers, whose respiratory impedance was measured using a MostGraph-01 and other pulmonary functions including Cst and lung resistance (R<sub>L</sub>) were measured on the same day and were retrospectively collected and compared. 31213791

2019

Entrez Id: 260431
Gene Symbol: COPD
COPD
CUI: C0865800
Disease: asthma with copd
asthma with copd
0.100 GeneticVariation BEFREE <b>Patients and methods:</b> The data of 18 patients with OLD (16 with COPD, two with asthma COPD overlap), 11 with ILD, and 24 healthy volunteers, whose respiratory impedance was measured using a MostGraph-01 and other pulmonary functions including Cst and lung resistance (R<sub>L</sub>) were measured on the same day and were retrospectively collected and compared. 31213791

2019

Entrez Id: 260431
Gene Symbol: COPD
COPD
CUI: C0011849
Disease: Diabetes Mellitus
Diabetes Mellitus
0.100 GeneticVariation BEFREE <b>Results</b> Preoperative data were similar regarding age (62.78 ± 9.96 vs. 62.98 ± 9.66 years; <i>p</i> = 0.734), female sex (17.5 vs. 18.6%; <i>p</i> = 0.631), diabetes mellitus (26.3 vs. 27.2%; <i>p</i> = 0.74), EuroSCORE (3.21 ± 2.23 vs. 3.18 ± 2.41; <i>p</i> = 0.968), and COPD (16 vs. 16%; <i>p</i> = 1). 28110487

2017

Entrez Id: 260431
Gene Symbol: COPD
COPD
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.100 Biomarker BEFREE <i>ACE</i> gene polymorphism is associated with COPD and COPD with pulmonary hypertension: a meta-analysis. 30147309

2018

Entrez Id: 260431
Gene Symbol: COPD
COPD
CUI: C0004096
Disease: Asthma
Asthma
0.100 Biomarker BEFREE <i>Methods:</i> This was a cross-sectional survey study of adults using inhaled controllers intended for BID dosing for treatment of asthma and/or COPD. 30395748

2019

Entrez Id: 260431
Gene Symbol: COPD
COPD
CUI: C0001883
Disease: Airway Obstruction
Airway Obstruction
0.100 Biomarker BEFREE <i>Methods:</i> We retrospectively compared the effect of an ambulatory PR program in nonsmoking patients with severe asthma and airway obstruction (FEV1/FVC ratio <70% and FEV1 < 80% measured twice, not under an exacerbation) and sex-, age-, FEV1-, and BMI-matched COPD controls. 30693816

2019

Entrez Id: 260431
Gene Symbol: COPD
COPD
CUI: C0010200
Disease: Coughing
Coughing
0.100 Biomarker BEFREE <i>Objective.</i> In China, the Chinese medicine formula modified zhisou powder (MZP) is commonly used to treat COPD with cold-dryness syndrome (CDSCOPD) to relieve cough and sputum. 30105060

2018

Entrez Id: 260431
Gene Symbol: COPD
COPD
CUI: C0085624
Disease: Burning sensation
Burning sensation
0.030 Biomarker BEFREE <i>TNF</i> promoter polymorphisms are associated with genetic susceptibility in COPD secondary to tobacco smoking and biomass burning. 29497291

2018

Entrez Id: 260431
Gene Symbol: COPD
COPD
CUI: C0035204
Disease: Respiration Disorders
Respiration Disorders
0.100 Biomarker BEFREE 12 risk factors with significant differences found between COPD and control groups were listed as follows: male sex (OR = 1.467; 95%CI: 1.097-1.962), smoking (OR = 2.092; 95%CI: 1.707-2.565), low educational level (OR = 1.609; 95%CI: 1.206-2.147), low BMI (OR = 3.831; 95%CI: 2.223-6.603), family history of respiratory disease (OR = 2.068; 95%CI: 1.466-2.918), allergy history (OR = 2.381; 95%CI: 1.385-4.093), respiratory infection during childhood (OR = 2.695; 95%CI: 1.504-4.828), recurrent respiratory infection (OR = 15.015; 95%CI: 4.538-49.684), occupational dust exposure (OR = 1.791; 95%CI: 1.151-2.788), biomass burning (OR = 2.218; 95%CI: 1.308-3.762), poor housing ventilation (OR = 3.993; 95%CI: 1.244-12.820), and living around polluted area (OR = 1.631; 95%CI: 1.202-2.214). 28947023

2017

Entrez Id: 260431
Gene Symbol: COPD
COPD
CUI: C0035242
Disease: Respiratory Tract Diseases
Respiratory Tract Diseases
0.100 Biomarker BEFREE 12 risk factors with significant differences found between COPD and control groups were listed as follows: male sex (OR = 1.467; 95%CI: 1.097-1.962), smoking (OR = 2.092; 95%CI: 1.707-2.565), low educational level (OR = 1.609; 95%CI: 1.206-2.147), low BMI (OR = 3.831; 95%CI: 2.223-6.603), family history of respiratory disease (OR = 2.068; 95%CI: 1.466-2.918), allergy history (OR = 2.381; 95%CI: 1.385-4.093), respiratory infection during childhood (OR = 2.695; 95%CI: 1.504-4.828), recurrent respiratory infection (OR = 15.015; 95%CI: 4.538-49.684), occupational dust exposure (OR = 1.791; 95%CI: 1.151-2.788), biomass burning (OR = 2.218; 95%CI: 1.308-3.762), poor housing ventilation (OR = 3.993; 95%CI: 1.244-12.820), and living around polluted area (OR = 1.631; 95%CI: 1.202-2.214). 28947023

2017

Entrez Id: 260431
Gene Symbol: COPD
COPD
CUI: C0035243
Disease: Respiratory Tract Infections
Respiratory Tract Infections
0.070 Biomarker BEFREE 12 risk factors with significant differences found between COPD and control groups were listed as follows: male sex (OR = 1.467; 95%CI: 1.097-1.962), smoking (OR = 2.092; 95%CI: 1.707-2.565), low educational level (OR = 1.609; 95%CI: 1.206-2.147), low BMI (OR = 3.831; 95%CI: 2.223-6.603), family history of respiratory disease (OR = 2.068; 95%CI: 1.466-2.918), allergy history (OR = 2.381; 95%CI: 1.385-4.093), respiratory infection during childhood (OR = 2.695; 95%CI: 1.504-4.828), recurrent respiratory infection (OR = 15.015; 95%CI: 4.538-49.684), occupational dust exposure (OR = 1.791; 95%CI: 1.151-2.788), biomass burning (OR = 2.218; 95%CI: 1.308-3.762), poor housing ventilation (OR = 3.993; 95%CI: 1.244-12.820), and living around polluted area (OR = 1.631; 95%CI: 1.202-2.214). 28947023

2017

Entrez Id: 260431
Gene Symbol: COPD
COPD
CUI: C0085624
Disease: Burning sensation
Burning sensation
0.030 Biomarker BEFREE 12 risk factors with significant differences found between COPD and control groups were listed as follows: male sex (OR = 1.467; 95%CI: 1.097-1.962), smoking (OR = 2.092; 95%CI: 1.707-2.565), low educational level (OR = 1.609; 95%CI: 1.206-2.147), low BMI (OR = 3.831; 95%CI: 2.223-6.603), family history of respiratory disease (OR = 2.068; 95%CI: 1.466-2.918), allergy history (OR = 2.381; 95%CI: 1.385-4.093), respiratory infection during childhood (OR = 2.695; 95%CI: 1.504-4.828), recurrent respiratory infection (OR = 15.015; 95%CI: 4.538-49.684), occupational dust exposure (OR = 1.791; 95%CI: 1.151-2.788), biomass burning (OR = 2.218; 95%CI: 1.308-3.762), poor housing ventilation (OR = 3.993; 95%CI: 1.244-12.820), and living around polluted area (OR = 1.631; 95%CI: 1.202-2.214). 28947023

2017