Source: BEFREE

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5209
Gene Symbol: PFKFB3
PFKFB3
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis 		0.060 Biomarker BEFREE 6-phosphate fructose-2-kinase/fructose-2,6-bisphosphatase-3 (PFKFB3) is a well-known glycolytic activator that plays an important role in tumorigenesis. 29335521

2018
Entrez Id: 5209
Gene Symbol: PFKFB3
PFKFB3
CUI: C1168401
Disease: Squamous cell carcinoma of the head and neck
Squamous cell carcinoma of the head and neck 		0.020 AlteredExpression BEFREE HNSCC showed an increased PFKFB3 expression compared with adjacent mucosal tissues (P < 0.01). 28061878

2017
Entrez Id: 5209
Gene Symbol: PFKFB3
PFKFB3
CUI: C0028754
Disease: Obesity
Obesity 		0.310 AlteredExpression BEFREE PFKFB3, a potential regulator of glycolysis, displays decreased mRNA levels in adipose tissue of obese women, is associated with obesity and is a new promising candidate gene for obesity warranting further studies. 18180783

2008
Entrez Id: 5209
Gene Symbol: PFKFB3
PFKFB3
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.100 Biomarker BEFREE PFKFB3 activation in cancer cells by the p38/MK2 pathway in response to stress stimuli. 23548149

2013
Entrez Id: 5209
Gene Symbol: PFKFB3
PFKFB3
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm 		0.100 Biomarker BEFREE PFKFB3 activation in cancer cells by the p38/MK2 pathway in response to stress stimuli. 23548149

2013
Entrez Id: 5209
Gene Symbol: PFKFB3
PFKFB3
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis 		0.030 Biomarker BEFREE PFKFB3 deficiency also constrained the ability of RA T cells to resort to autophagy as an alternative means to provide energy and biosynthetic precursor molecules. 24043759

2013
Entrez Id: 5209
Gene Symbol: PFKFB3
PFKFB3
CUI: C1960398
Disease: HER2-positive carcinoma of breast
HER2-positive carcinoma of breast 		0.010 Biomarker BEFREE PFKFB3 is elevated in human HER2+ breast cancer and high PFKFB3 transcript correlated with poorer progression-free (PFS) and distant metastatic-free (DFMS) survival. 27613609

2016
Entrez Id: 5209
Gene Symbol: PFKFB3
PFKFB3
CUI: C4733095
Disease: HER2-negative breast cancer
HER2-negative breast cancer 		0.010 Biomarker BEFREE PFKFB3 is elevated in human HER2+ breast cancer and high PFKFB3 transcript correlated with poorer progression-free (PFS) and distant metastatic-free (DFMS) survival. 27613609

2016
Entrez Id: 5209
Gene Symbol: PFKFB3
PFKFB3
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis 		0.070 Biomarker BEFREE PFKFB3-blockade treatment also improved chemotherapy of primary and metastatic tumors. 27866851

2016
Entrez Id: 5209
Gene Symbol: PFKFB3
PFKFB3
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis 		0.070 Biomarker BEFREE PFKFB3 blockade therefore results in tumor vessel normalization, with beneficial therapeutic effects on reduced metastasis and improved chemotherapy. 28212191

2017
Entrez Id: 5209
Gene Symbol: PFKFB3
PFKFB3
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis 		0.030 AlteredExpression BEFREE PFKFB3 expression was increased in the synovial tissue and FLSs from RA patients compared with osteoarthritis patients. 28239846

2017
Entrez Id: 5209
Gene Symbol: PFKFB3
PFKFB3
CUI: C0029408
Disease: Degenerative polyarthritis
Degenerative polyarthritis 		0.020 AlteredExpression BEFREE PFKFB3 expression was increased in the synovial tissue and FLSs from RA patients compared with osteoarthritis patients. 28239846

2017
Entrez Id: 5209
Gene Symbol: PFKFB3
PFKFB3
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.100 AlteredExpression BEFREE 6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase isoform 3 (PFKFB3), is a critical enzyme for glycolysis and highly expressed in cancer cells. 29113354

2017
Entrez Id: 5209
Gene Symbol: PFKFB3
PFKFB3
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm 		0.100 AlteredExpression BEFREE 6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase isoform 3 (PFKFB3), is a critical enzyme for glycolysis and highly expressed in cancer cells. 29113354

2017
Entrez Id: 5209
Gene Symbol: PFKFB3
PFKFB3
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.100 Biomarker BEFREE PFKFB3 as a glycolytic activator has been implicated in the progression of multiple types of tumor. 29151977

2017
Entrez Id: 5209
Gene Symbol: PFKFB3
PFKFB3
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis 		0.070 Biomarker BEFREE PFKFB3 can be contributed to the progression and metastasis of cancer. 29151977

2017
Entrez Id: 5209
Gene Symbol: PFKFB3
PFKFB3
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.100 Biomarker BEFREE PFKFB3 can be contributed to the progression and metastasis of cancer. 29151977

2017
Entrez Id: 5209
Gene Symbol: PFKFB3
PFKFB3
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm 		0.100 Biomarker BEFREE PFKFB3 can be contributed to the progression and metastasis of cancer. 29151977

2017
Entrez Id: 5209
Gene Symbol: PFKFB3
PFKFB3
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.040 Biomarker BEFREE PFKFB3 is a potential novel target in the treatment of HCC. 29559632

2018
Entrez Id: 5209
Gene Symbol: PFKFB3
PFKFB3
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.100 Biomarker BEFREE 6-Phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 and 4: A pair of valves for fine-tuning of glucose metabolism in human cancer. 30553771

2019
Entrez Id: 5209
Gene Symbol: PFKFB3
PFKFB3
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm 		0.100 Biomarker BEFREE 6-Phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 and 4: A pair of valves for fine-tuning of glucose metabolism in human cancer. 30553771

2019
Entrez Id: 5209
Gene Symbol: PFKFB3
PFKFB3
CUI: C2973725
Disease: Pulmonary arterial hypertension
Pulmonary arterial hypertension 		0.010 Biomarker BEFREE PFKFB3 in Smooth Muscle Promotes Vascular Remodeling in Pulmonary Arterial Hypertension. 30817168

2019
Entrez Id: 5209
Gene Symbol: PFKFB3
PFKFB3
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.100 Biomarker BEFREE PFKFB3 in both cancer cells and tumor-associated monocytes is a potential therapeutic target in human HCC. 31071366

2019
Entrez Id: 5209
Gene Symbol: PFKFB3
PFKFB3
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm 		0.100 Biomarker BEFREE PFKFB3 in both cancer cells and tumor-associated monocytes is a potential therapeutic target in human HCC. 31071366

2019
Entrez Id: 5209
Gene Symbol: PFKFB3
PFKFB3
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.100 Biomarker BEFREE PFKFB3 in both cancer cells and tumor-associated monocytes is a potential therapeutic target in human HCC. 31071366

2019