Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 GeneticVariation BEFREE The high frequency of mutations of the p53 tumor-suppressor gene in human cancers, including primary brain tumors, suggests that p53 plays a critical role in carcinogenesis and tumor progression. 7644054

1995

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 GeneticVariation BEFREE Recent evidence indicates that some mutations in p53 arise as the cancer progresses from a benign tumor to a metastatic tumor and that these mutations in p53 actively contribute to the process of cancer progression. 16236433

2006

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 GeneticVariation BEFREE These results suggest that (i) significant differences in the frequency of p53 mutations are present among subtypes of neoplasms derived from the same tissue; (ii) p53 may play a role in tumor progression in B-cell chronic lymphocytic leukemia; (iii) the presence of both p53 loss/inactivation and c-myc oncogene activation may be important in the pathogenesis of Burkitt lymphoma and its leukemic form L3-type B-cell acute lymphoblastic leukemia. 2052620

1991

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 GeneticVariation BEFREE K-ras mutation is critical in the formation of ACF, but p53 alteration could play a causal role in tumor progression. 7835585

1995

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 GeneticVariation BEFREE These findings suggest that wt p53 protein has a function in maintaining genomic stability after X-ray irradiation through the G1 checkpoint and loss of p53 function(s) may lead to tumor progression in multi-step tumorigenesis. 9111202

1997

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 GeneticVariation BEFREE We conclude that p53 protein overexpression is a common finding in some entities of T- and T/NK-cell lymphomas, whereas a p53 gene mutation is a rare, sporadic, and rather late event associated with tumor progression in some instances. 11230707

2001

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 GeneticVariation BEFREE Different missense mutations in p53 may confer unique activities and thereby offer insight into the mutagenic events that drive tumor progression. 22713868

2012

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 GeneticVariation BEFREE To further examine the idea that neoplastic progression is associated with mutations in the p53 gene, we analyzed matched primary and metastatic tumor samples. 7619219

1995

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 GeneticVariation BEFREE Wip1 over-expression inhibits p53 function and reduces selection for TP53 mutations during cancer progression. 21695702

2011

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 GeneticVariation BEFREE Mutation and deletion of the p53 tumor suppressor gene are arguably the most prevalent among the multiple genetic alterations found in human bladder cancer, but these p53 defects are primarily associated with the advanced diseases, and their roles in bladder tumor initiation and in synergizing with oncogenes in tumor progression have yet to be defined. 14737103

2004

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 GeneticVariation BEFREE Notably, TP53 mutation, which has been used as a marker of tumor progression in many human cancers, was less significant in associating with progression in this study (P = 0.04) than was p16 or pRb alteration (P = 0.001). 9436977

1998

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 GeneticVariation BEFREE Our results yield two implications: that p53 alterations have a crucial and early role in gastric carcinogenesis of intestinal type, likely acting at the transition step between metaplasia and dysplasia; and that the alterations are mainly associated with tumor progression in cancer of diffuse type. 7606196

1995

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 GeneticVariation BEFREE The aim of this study was to investigate the hypothesis that altered patterns of expression of the protein product(s) of the mutated p53 tumor suppressor gene are associated with tumor progression in patients with T1 bladder cancer. 7677935

1993

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 GeneticVariation BEFREE Neoplastic progression in BE is associated with alterations in TP53 (also known as p53) and CDKN2A (also known as p16) and non-random losses of heterozygosity (LOH). 10319873

1999

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 GeneticVariation BEFREE These results imply that p53 plays a role in the repair of ABP adducts and that in p53 null cells the unrepaired DNA damage could cause accumulation of mutations, which might contribute to increased genomic instability and neoplastic progression. 11159753

2001

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 GeneticVariation BEFREE Spontaneous epigenetic mutational events are involved in tumor progression and while radiation increases the absolute prevalence of thyroid cancer in the susceptible it does not increase the rate of p53 mutation and seemingly targets different non-DNA-contact residues than those in spontaneously arising tumors. 11161841

2001

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 GeneticVariation BEFREE Centrosome defects have been implicated in disease and tumor progression and have been associated with nullizygosity of the p53 tumor suppressor gene. 10595924

1999

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 GeneticVariation BEFREE TP53 missense mutations dramatically influence tumor progression, however, their mechanism of action is still poorly understood. 21741598

2011

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 GeneticVariation BEFREE Various lines of evidence indicate that, in addition to abrogating the tumor suppressor functions of wild-type p53, the common types of cancer-associated p53 mutations also endow the mutant protein with new activities that can contribute actively to various stages of tumor progression and to increased resistance to anticancer treatments. 20182618

2010

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 GeneticVariation BEFREE A large fraction of human tumors carry p53 mutation, allowing evasion of apoptosis and tumor progression. 19633417

2009

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 GeneticVariation BEFREE Tumor progression in hepatocellular carcinoma may be mediated by p53 mutation. 8389246

1993

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 GeneticVariation BEFREE Mutant p53 gain of function contributes to cancer progression, increased invasion and metastasis potentials, and resistance to anticancer therapy. 19258312

2009

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 GeneticVariation BEFREE The role of combined allelic imbalance and mutations of p53 in tumor progression and survival following surgery for colorectal carcinoma. 16273227

2006

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 GeneticVariation BEFREE Increased p53 mutation frequency during tumor progression--results from a breast cancer cohort. 11719465

2001

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 GeneticVariation BEFREE In some malignancies, p53 mutations are associated with tumor progression. 11596036

2001