Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE These observations indicate that human papillomavirus 11-associated neoplastic transformation and tumor progression in the respiratory tract may not involve aberrant regulation of the p53 and Rb signaling pathways. 15668901

2005

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 GeneticVariation BEFREE The high frequency of mutations of the p53 tumor-suppressor gene in human cancers, including primary brain tumors, suggests that p53 plays a critical role in carcinogenesis and tumor progression. 7644054

1995

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE Oncogenic stimuli trigger the DNA damage response (DDR) and induction of the alternative reading frame (ARF) tumor suppressor, both of which can activate the p53 pathway and provide intrinsic barriers to tumor progression. 23852374

2014

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE Inflammation-induced activation of proto-oncogenic NF-κB/REL and dysfunction of tumor suppressor TP53/p63/p73 family transcription factors are key events in cancer progression. 21933882

2012

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE Therefore, the binding of Mdm2 to the Slug mRNA appears to provide a novel mechanism through which Mdm2 promotes tumor progression in a manner independent of the presence of p53. 23438693

2013

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 GeneticVariation BEFREE Recent evidence indicates that some mutations in p53 arise as the cancer progresses from a benign tumor to a metastatic tumor and that these mutations in p53 actively contribute to the process of cancer progression. 16236433

2006

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE One of the most important p53 functions is its ability to activate apoptosis, and disruption of this process can promote tumor progression and chemoresistance. p53 apparently promotes apoptosis through transcription-dependent and -independent mechanisms that act in concert to ensure that the cell death program proceeds efficiently. 14663481

2004

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 GeneticVariation BEFREE These results suggest that (i) significant differences in the frequency of p53 mutations are present among subtypes of neoplasms derived from the same tissue; (ii) p53 may play a role in tumor progression in B-cell chronic lymphocytic leukemia; (iii) the presence of both p53 loss/inactivation and c-myc oncogene activation may be important in the pathogenesis of Burkitt lymphoma and its leukemic form L3-type B-cell acute lymphoblastic leukemia. 2052620

1991

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE Cancer progression and p53. 7475551

1995

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 GeneticVariation BEFREE K-ras mutation is critical in the formation of ACF, but p53 alteration could play a causal role in tumor progression. 7835585

1995

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE The p53 family and the hypoxia-inducible factors (HIFs): determinants of cancer progression. 26032560

2016

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE These studies reveal that p53 contributes to a metabolically regulated G1 check-point, and they provide a model for understanding how abnormal cell cycle progression leads to the genetic rearrangements involved in tumor progression. 1525830

1992

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 GeneticVariation BEFREE These findings suggest that wt p53 protein has a function in maintaining genomic stability after X-ray irradiation through the G1 checkpoint and loss of p53 function(s) may lead to tumor progression in multi-step tumorigenesis. 9111202

1997

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 AlteredExpression BEFREE TP53 and MDM2 genes and their protein expression were evaluated in frozen and paraffin-embedded tissue from 27 patients with malignant fibrous histiocytoma to elucidate the relationship between them, their implication in tumor progression mechanisms and their possible diagnostic-prognostic value in malignant fibrous histiocytoma. 10628802

2000

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 AlteredExpression BEFREE Overall, we confirmed that expression of KAI1 mRNA decreased from normal tissue, through localised cancer to bony metastases (P=0.055, tending to significance), while levels of p53 staining significantly increased with cancer progression (P=0.046). 12806379

2004

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE On the contrary, p53 loss led to increased apoptosis that had to be overcome for tumor progression. 24469052

2015

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE Concerning the results above, we conclude that the allelic imbalance of the Rb or p53 gene itself is not implicated as a major contributing factor in the malignant transformation or the tumor progression in HPV-positive uterine cervical cancers. 9367711

1997

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 GeneticVariation BEFREE We conclude that p53 protein overexpression is a common finding in some entities of T- and T/NK-cell lymphomas, whereas a p53 gene mutation is a rare, sporadic, and rather late event associated with tumor progression in some instances. 11230707

2001

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 GeneticVariation BEFREE Different missense mutations in p53 may confer unique activities and thereby offer insight into the mutagenic events that drive tumor progression. 22713868

2012

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE Growth differentiation factor-15 (GDF-15), a member of the TGF-β superfamily, has been shown to be a downstream target of p53 and is associated with diverse human diseases and cancer progression. 21586550

2011

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 GeneticVariation BEFREE To further examine the idea that neoplastic progression is associated with mutations in the p53 gene, we analyzed matched primary and metastatic tumor samples. 7619219

1995

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 GeneticVariation BEFREE Wip1 over-expression inhibits p53 function and reduces selection for TP53 mutations during cancer progression. 21695702

2011

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE These data are consistent with a model in which loss of p53 function enables acquisition of stem cell properties, which are positively selected during tumor progression. 21149740

2011

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE These results suggest that: (a) bladder cancers with high pRb expression do not show the tumor suppressor effects of the protein; and (b) alteration in both p53 and pRb may act in cooperative or synergistic ways to promote tumor progression. 9515785

1998

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 GeneticVariation BEFREE Mutation and deletion of the p53 tumor suppressor gene are arguably the most prevalent among the multiple genetic alterations found in human bladder cancer, but these p53 defects are primarily associated with the advanced diseases, and their roles in bladder tumor initiation and in synergizing with oncogenes in tumor progression have yet to be defined. 14737103

2004