×
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
Carcinoma of lung
0.700
GeneticVariation
BEFREE
Lung cancer TCGA data validated these findings and unveiled overlap of FGFR1 mRNA positivity with KRAS and PIK3CA mutations.24771645 2014
×
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
Carcinoma of lung
0.700
GeneticVariation
BEFREE
Lung cancer is the leading cause of cancer related deaths worldwide and mutation activating KRAS is one of the most frequent mutations found in lung adenocarcinoma.29191600 2017
×
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
Carcinoma of lung
0.700
GeneticVariation
BEFREE
Lung cancer cell lines with KRAS mutation were relatively more sensitive to KRA-533 than cell lines without KRAS mutation.30971271 2019
×
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
Carcinoma of lung
0.700
GeneticVariation
BEFREE
K-ras gene point mutation in neogenetic lesions of subpleural fibrotic lesions: either an early genetic event in lung cancer development or a non-specific genetic change during the inflammatory reparative process.10417684 1999
×
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
Carcinoma of lung
0.700
GeneticVariation
BEFREE
KRAS gene mutations in lung cancer : particulars established and issues unresolved.20846262 2010
×
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
Carcinoma of lung
0.700
GeneticVariation
BEFREE
KRAS is a downstream mediator of EGFR-induced cell signaling, such mutations appear to be mutually exclusive from EGFR mutations in lung cancer .21428885 2011
×
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
Carcinoma of lung
0.700
GeneticVariation
BEFREE
KRAS mutation is a poor prognosis factor, but it is not an independent predictor of response to EGFR-TKI or chemotherapy in patients with lung cancer .23208128 2013
×
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
Carcinoma of lung
0.700
Biomarker
BEFREE
KRAS mutations (codons 12/13) were found to be a biomarker of radiosensitization by midostaurin in lung cancer , which was pronounced under conditions that enriched for stem cell-like cells.25667133 2015
×
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
Carcinoma of lung
0.700
GeneticVariation
BEFREE
KRAS mutations commonly occurred with loss in TP53 and there was significant loss of BRCA1 and NF1 among male patients with lung cancer .26880400 2016
×
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
Carcinoma of lung
0.700
Biomarker
BEFREE
KRAS oncogene in lung cancer : focus on molecularly driven clinical trials.26929424 2016
×
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
Carcinoma of lung
0.700
GeneticVariation
BEFREE
KRAS -mutated lung cancer cell clones were stably silenced for LSD1 expression.28860622 2017
×
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
Carcinoma of lung
0.700
Biomarker
BEFREE
KRAS : Reasons for optimism in lung cancer .29894909 2018
×
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
Carcinoma of lung
0.700
GeneticVariation
BEFREE
KRAS mutations may act as a resistance mechanism to MET inhibition in MET dependent lung cancer .31200822 2019
×
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
Carcinoma of lung
0.700
GeneticVariation
BEFREE
K-ras gene point mutations were detected in five cases of lung carcinoma , of which four were adenocarcinomas and one was squamous cell carcinoma.8081702 1994
×
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
Carcinoma of lung
0.700
AlteredExpression
BEFREE
A dominant-negative DUSP6 mutant, however, failed to rescue KRAS/V12-induced growth suppression, but conferred a stronger anchorage-independent growth activity to the surviving subpopulation of cells generated from KRAS /V12-transduced NHBE-T. DUSP6 expression levels were found to be weaker in most lung cancer cell lines than in NHBE-T, and DUSP6 restoration suppressed cellular growth.
19608870 2009
×
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
Carcinoma of lung
0.700
GeneticVariation
BEFREE
A major locus affecting inherited predisposition to lung cancer in mice has been mapped on chromosome 6, near the Kras2 gene.
8967717 1996
×
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
Carcinoma of lung
0.700
Biomarker
BEFREE
A model of K-Ras -initiated lung cancer was used to follow the transition of precancerous adenoma to adenocarcinoma.
29930325 2018
×
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
Carcinoma of lung
0.700
GeneticVariation
BEFREE
A proof-of-principle screen was done on the KRAS mutant lung cancer cell line H460 and a Custom Clinical Collection (146 compounds).
24922006 2014
×
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
Carcinoma of lung
0.700
AlteredExpression
BEFREE
A recently described variant allele in the KRAS 3' untranslated region that arises in the let-7 miRNA complementary site (KRAS -LCS6) and leads to increased KRAS expression in lung cancer was examined for its association with the occurrence of head and neck squamous cell carcinoma (HNSCC).
19380522 2009
×
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
Carcinoma of lung
0.700
GeneticVariation
BEFREE
A robotic screen found that lung cancer cells with KRAS mutation were particularly sensitive to CCT68127 ( P = .02 for IC 50 ).
28376145 2017
×
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
Carcinoma of lung
0.700
GeneticVariation
BEFREE
A total of 1271 small molecules were screened in KRAS -mutant and wild-type lung cancer cell lines.
30862488 2019
×
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
Carcinoma of lung
0.700
GeneticVariation
BEFREE
Abemaciclib, a CDK4/6-selective inhibitor, is currently in phase III studies for ER-positive breast cancer and KRAS mutant lung cancer .
29059158 2018
×
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
Carcinoma of lung
0.700
Biomarker
BEFREE
Activated KRAS is frequently observed and paralleled by inactivating of tumor suppressors in lung cancer , while the mechanisms remained elusive.
30906631 2019
×
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
Carcinoma of lung
0.700
GeneticVariation
BEFREE
Activating mutation of the K-ras gene was one of the earliest discoveries of genetic alterations in lung cancer .
19589613 2010
×
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
Carcinoma of lung
0.700
GeneticVariation
BEFREE
Activation of FOSL1 in adenocarcinomas may be a prognostic marker and potential target for human lung cancer with KRAS mutations.
29112457 2018