Source: BEFREE

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.100 GeneticVariation BEFREE "Masculinity theory" was used to report the impact of having both a BRCA1/2 mutation and PCa. 28812325

2017

Entrez Id: 100505887
Gene Symbol: LINC01672
LINC01672
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.050 Biomarker BEFREE <b>Abbreviation used:</b> A549 (human lung carcinoma), Caco-2 (Human ColonCarcinoma), CHCl3 (Chloroform), HCT 116 (Human Colon Carcinoma), HepG2 (Liver Hepatocellular Carcinoma), HT-29 (Human Colorectal Adenocarcinoma), MCF-7 (Michigan Cancer Foundation-7; Human Breast Adenocarcinoma), MeOH (Methanol), NMR Nuclear Magnetic Resonance), PBS (Phosphate Buffered Saline), PC-3 (Human Prostate Cancer), PTLC (Preparative Thin Layer Chromatography), RPMI-1640 (Roswell Park Memorial Institute medium), TLC (ThinLayer Chromatography). 28479724

2017

Entrez Id: 3146
Gene Symbol: HMGB1
HMGB1
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.100 Biomarker BEFREE <b>Background and Aim</b>: We have previously shown that high-mobility group box 1 (<i>HMGB1</i>) is an independent biomarker for shortened survival of prostate cancer (PCa) patients. 31410208

2019

Entrez Id: 2346
Gene Symbol: FOLH1
FOLH1
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.100 Biomarker BEFREE <b>Background:</b> By targeting the prostate-specific membrane antigen (PSMA) on prostate cancer (PCa) cells PSMA-PET/CT shows great potential in locating the site of biochemical recurrence even at low PSA (Prostate-specific antigen)-levels. 28529650

2017

Entrez Id: 354
Gene Symbol: KLK3
KLK3
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.200 Biomarker BEFREE <b>Background:</b> By targeting the prostate-specific membrane antigen (PSMA) on prostate cancer (PCa) cells PSMA-PET/CT shows great potential in locating the site of biochemical recurrence even at low PSA (Prostate-specific antigen)-levels. 28529650

2017

Entrez Id: 29968
Gene Symbol: PSAT1
PSAT1
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.100 Biomarker BEFREE <b>Background:</b> By targeting the prostate-specific membrane antigen (PSMA) on prostate cancer (PCa) cells PSMA-PET/CT shows great potential in locating the site of biochemical recurrence even at low PSA (Prostate-specific antigen)-levels. 28529650

2017

Entrez Id: 9520
Gene Symbol: NPEPPS
NPEPPS
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.100 Biomarker BEFREE <b>Background:</b> By targeting the prostate-specific membrane antigen (PSMA) on prostate cancer (PCa) cells PSMA-PET/CT shows great potential in locating the site of biochemical recurrence even at low PSA (Prostate-specific antigen)-levels. 28529650

2017

Entrez Id: 5627
Gene Symbol: PROS1
PROS1
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.100 Biomarker BEFREE <b>Background:</b> By targeting the prostate-specific membrane antigen (PSMA) on prostate cancer (PCa) cells PSMA-PET/CT shows great potential in locating the site of biochemical recurrence even at low PSA (Prostate-specific antigen)-levels. 28529650

2017

Entrez Id: 5324
Gene Symbol: PLAG1
PLAG1
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.100 Biomarker BEFREE <b>Background:</b> By targeting the prostate-specific membrane antigen (PSMA) on prostate cancer (PCa) cells PSMA-PET/CT shows great potential in locating the site of biochemical recurrence even at low PSA (Prostate-specific antigen)-levels. 28529650

2017

Entrez Id: 354
Gene Symbol: KLK3
KLK3
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.200 Biomarker BEFREE <b>Background:</b> This study sought to ascertain whether there is an association between prostate cancer (PC)-specific mortality (PCSM) and timing of salvage androgen deprivation therapy (ADT) among men with short versus long prostate-specific antigen doubling times (PSA-DTs). 29891524

2018

Entrez Id: 55503
Gene Symbol: TRPV6
TRPV6
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.100 Biomarker BEFREE <b>Background:</b> Transient Receptor Potential Vanilloid 6 (TRPV6), a non-voltage gated calcium channel, is implicated in malignancies and correlates with Gleason scores in prostate cancer and with poor prognosis in breast cancer. 30210643

2018

Entrez Id: 6935
Gene Symbol: ZEB1
ZEB1
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.100 Biomarker BEFREE <b>Conclusion</b>: Our findings elucidated that copy number gains of ZEB1-triggered a TGF-β signaling-dependent miR-33a-5p-mediated negative feedback loop was highly relevant to the bone metastasis of PCa. 31534537

2019

Entrez Id: 1545
Gene Symbol: CYP1B1
CYP1B1
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.100 GeneticVariation BEFREE <b>Conclusion.</b> This meta-analysis revealed a clear association between rs1048943 and rs4646903 polymorphisms of the <i>CYP1A1</i> gene but not between CYP1B1 rs10012, rs162549, rs1800440, and rs2551188 polymorphisms and the risk of PCa. 30765615

2019

Entrez Id: 2346
Gene Symbol: FOLH1
FOLH1
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.100 Biomarker BEFREE <b>Conclusion:</b> PSMA-targeting probes with trifluoroborate prosthetic groups represent promising candidates for prostate cancer imaging because of facile labeling while affording high tumor uptake values and contrast ratios that are similar to those obtained with <sup>18</sup>F-DCFPyL. 30737299

2019

Entrez Id: 2346
Gene Symbol: FOLH1
FOLH1
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.100 Biomarker BEFREE <b>Conclusion:</b> In our analysis, preoperative 1-stop-shop <sup>68</sup>Ga-PSMA-11 PET/MRI performs at least equally for T and N stage prediction compared with nomograms in high-risk prostate cancer patients. 29794224

2018

Entrez Id: 2346
Gene Symbol: FOLH1
FOLH1
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.100 Biomarker BEFREE <b>Conclusion:</b> In this pilot study, <sup>18</sup>F-PSMA-1007 PET/CT presented high potential for localization of recurrent disease in prostate cancer patients with BCR. 29419475

2018

Entrez Id: 51386
Gene Symbol: EIF3L
EIF3L
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.010 Biomarker BEFREE <b>Conclusion:</b> In this study, we demonstrated that the regulation of eIF3L palmitoylation may provide new directions for the therapy of prostate cancer. 31239713

2019

Entrez Id: 1545
Gene Symbol: CYP1B1
CYP1B1
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.100 GeneticVariation BEFREE <b>CONCLUSION:</b> Our findings suggest that genetic variants within <i>CYP1B1</i> may confer genetic susceptibility to PCa by altering telomere length. 29344273

2018

Entrez Id: 6868
Gene Symbol: ADAM17
ADAM17
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.040 AlteredExpression BEFREE <b>Conclusion:</b> Overexpression of circHIPK3 promotes the proliferative and invasive potentials of PCa cells through sponging miRNA-338-3p to regulate ADAM17 expression, thus accelerating the malignant progression of PCa. 31118688

2019

Entrez Id: 6462
Gene Symbol: SHBG
SHBG
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.100 AlteredExpression BEFREE <b>Conclusion:</b> Prebinding of <sup>18</sup>F-FDHT to SHBG allows accurate and quantitative PET imaging of AR levels in murine models of prostate cancer. 29853654

2018

Entrez Id: 2346
Gene Symbol: FOLH1
FOLH1
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.100 GeneticVariation BEFREE <b>Conclusion:</b> Synchronous <sup>68</sup>Ga-labeled prostate-specific membrane antigen-avid malignancies were rare (0.7%) in PC patients; atypical lesions were more commonly unusual PC metastases (1.0%) or benign (3.1%). 28572488

2017

Entrez Id: 2346
Gene Symbol: FOLH1
FOLH1
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.100 Biomarker BEFREE <b>Conclusion:</b> The combination of Lu-PSMA and SIRT is efficient and feasible for the treatment of advanced prostate cancer. 31601703

2019

Entrez Id: 407040
Gene Symbol: MIR34A
MIR34A
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.100 Biomarker BEFREE <b>Conclusion:</b> The DANCR/miR-34a-5p axis enhanced DTX resistance of PC via targeting JAG1, providing a novel insight to improve chemotherapy for PC. 31371987

2019

Entrez Id: 182
Gene Symbol: JAG1
JAG1
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.070 Biomarker BEFREE <b>Conclusion:</b> The DANCR/miR-34a-5p axis enhanced DTX resistance of PC via targeting JAG1, providing a novel insight to improve chemotherapy for PC. 31371987

2019

Entrez Id: 2346
Gene Symbol: FOLH1
FOLH1
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.100 Biomarker BEFREE <b>Conclusion:</b> The radiofluorinated PSMA ligand showed promising characteristics in its preclinical evaluation, and the feasibility of prostate cancer imaging was demonstrated by small-animal PET studies. 27789722

2017