HLA-DRB1
|
Cervix carcinoma
|
0.100 |
Biomarker |
BEFREE |
HLA-DRB1∗01:01 (OR = 0.12; p = 0.01) may confer protection to the development of CC.
|
21911185 |
2011 |
HLA-DRB1
|
Cervix carcinoma
|
0.100 |
GeneticVariation |
BEFREE |
Accordingly, a specific MHC class II haplotype, DRB1*0901-DQB1*03032, may be a risk factor for cervical carcinoma in the Japanese population.
|
17433060 |
2008 |
HLA-DRB1
|
Cervix carcinoma
|
0.100 |
GeneticVariation |
BEFREE |
Association of HLA-DRB1, interleukin-6 and cyclin D1 polymorphisms with cervical cancer in the Swedish population--a candidate gene approach.
|
19585495 |
2009 |
HLA-DRB1
|
Cervix carcinoma
|
0.100 |
GeneticVariation |
BEFREE |
Consistent associations across other studies in women with CC and infected by HPV16 were observed for HLA-DRB1*15 (OR, 3.9; 95% CI, 1.6-10.2) and the haplotype DRB1*15 DQB1*0602 (OR, 4.1; 95% CI, 1.4-12.7) compared with control women.
|
19820376 |
2009 |
HLA-DRB1
|
Cervix carcinoma
|
0.100 |
GeneticVariation |
BEFREE |
Decreased frequency of HLA-DRB1 13 alleles in Frenchwomen with HPV-positive carcinoma of the cervix.
|
8682580 |
1996 |
HLA-DRB1
|
Cervix carcinoma
|
0.100 |
Biomarker |
BEFREE |
DQB1*0301 alone (2P = 0.02) and in combination with DRB1*0401 (2P = 0.02) was found to be associated with cervical cancer.
|
10755413 |
2000 |
HLA-DRB1
|
Cervix carcinoma
|
0.100 |
GeneticVariation |
BEFREE |
Further, protective associations were evidenced for alleles B*35 and DRB1*10 and haplotypes A*11-B*35 and DRB1*10-DQB1*0501 with cervical cancer in South India.
|
27268619 |
2016 |
HLA-DRB1
|
Cervix carcinoma
|
0.100 |
Biomarker |
BEFREE |
Haplotype analysis highlighted the significant association of HLA- DRB1*07:01-DQB1*02:02 and HLA DRB1*10:01-DQB1*05:01 with cervical cancer, while HLA-DRB1*14:04-DQB1*05:03 and DRB1*15:01-DQB1*06:01 conferred decreased risk for cervical cancer.
|
25673541 |
2014 |
HLA-DRB1
|
Cervix carcinoma
|
0.100 |
Biomarker |
BEFREE |
HLA-B*15 showed a negative association with HPV-16-positive CaCx (0.1, 0.01), whereas DRB1*04 exhibited protection to both HPV-16-positive CaCx and persistent HPV-16 infection (0.3, 0.0001 and 0.1, 0.0002, respectively).
|
31800372 |
2019 |
HLA-DRB1
|
Cervix carcinoma
|
0.100 |
Biomarker |
BEFREE |
Human Leukocyte Antigen (HLA) Class II -DRB1 and -DQB1 Alleles and the Association with Cervical Cancer in HIV/HPV Co-Infected Women in South Africa.
|
31258717 |
2019 |
HLA-DRB1
|
Cervix carcinoma
|
0.100 |
GeneticVariation |
BEFREE |
Human leukocyte antigen class II DRB1*1302 allele protects against cervical cancer: At which step of multistage carcinogenesis?
|
26235935 |
2015 |
HLA-DRB1
|
Cervix carcinoma
|
0.100 |
GeneticVariation |
BEFREE |
In a similar fashion, the occurrence of DRB1 *13-DQB1 *06 (OR, 0.17; 95% CI, 0.04-0.80) haplotype was significantly lower in the study patients compared with the controls and may confer a decreased risk of CC among Han race population in the Guangdong Province of China.
|
19027490 |
2008 |
HLA-DRB1
|
Cervix carcinoma
|
0.100 |
Biomarker |
BEFREE |
In previous studies, the HLA class II haplotype HLA DRB1*0401-DQB1*0301 was shown to correlate with susceptibility to HPV infection, CIN and cervical cancer while DRB1*0101-DQB1*0501 indicated protection.
|
11562779 |
2001 |
HLA-DRB1
|
Cervix carcinoma
|
0.100 |
Biomarker |
BEFREE |
Observations from this study confirm earlier findings of a negative association between DRB1*13 and cervical cancer and suggest that specific DRB1-DQB1 haplotype combinations, rather than individual DQB1*03 alleles, increase the risk for cervical cancer.
|
11588129 |
2001 |
HLA-DRB1
|
Cervix carcinoma
|
0.100 |
GeneticVariation |
BEFREE |
Our results support the hypothesis that the HLA-DRB1 family alleles and specific alleles might influence the susceptibility or resistance to cervical cancer, suggesting that immune regulation may play a key role in this disease, although further investigations are still needed.
|
24551099 |
2014 |
HLA-DRB1
|
Cervix carcinoma
|
0.100 |
Biomarker |
BEFREE |
Our results support the role of HLA-DRB1 and MICA in the pathogenesis of cervical cancer.
|
24403192 |
2014 |
HLA-DRB1
|
Cervix carcinoma
|
0.100 |
GeneticVariation |
BEFREE |
Protective association of HLA-DRB1*13:02, HLA-DRB1*04:06, and HLA-DQB1*06:04 alleles with cervical cancer in a Korean population.
|
30352277 |
2019 |
HLA-DRB1
|
Cervix carcinoma
|
0.100 |
GeneticVariation |
BEFREE |
The DRB1*13 allele/DRB1*13-DQB1*06 haplotype was strongly protective against risk to HPV infection (p(c) < 0.002) as well as cervical cancer (p(c) 0.01).
|
19272325 |
2009 |
HLA-DRB1
|
Cervix carcinoma
|
0.100 |
GeneticVariation |
BEFREE |
The association of HLA class II DQB1 and DRB1 alleles with the development of cervical carcinoma was studied in 150 Swedish patients using PCR-based HPV and HLA typing.
|
8864172 |
1996 |
HLA-DRB1
|
Cervix carcinoma
|
0.100 |
GeneticVariation |
BEFREE |
The frequency of HLA-DRB1 and -DQB1 alleles in cervical cancer cases in the Czech Republic.
|
10732716 |
1999 |
HLA-DRB1
|
Cervix carcinoma
|
0.100 |
GeneticVariation |
BEFREE |
The presence of the HLA-DRB1*13-2 and HLA-DRB1*3(17) alleles was associated with an increased risk of developing cervical cancer.
|
25223804 |
2014 |
HLA-DRB1
|
Cervix carcinoma
|
0.100 |
GeneticVariation |
BEFREE |
The strongest class II effects are coming from the DQB1 and DRB1 loci, but the DPB1 locus also contributes to the susceptibility to cervical cancer.
|
15238505 |
2004 |
HLA-DRB1
|
Cervix carcinoma
|
0.100 |
Biomarker |
BEFREE |
These results indicate that HLA-DPB1*1301 may confer susceptibility to cervical cancer, and the haplotypes DRB1*150101-DQB1*0602 and DRB1*070101-DQB1*0201 may contribute to the resistance to the development of cervical cancer among Chinese women.
|
17349874 |
2007 |
HLA-DRB1
|
Cervix carcinoma
|
0.100 |
GeneticVariation |
BEFREE |
Variation in LD between the classic HLA loci, rs9272143 and rs67841474 between populations may explain the different associations of HLA-B*07 and DRB1*1501-DQB1*0602 with cervical cancer between studies.
|
24520070 |
2014 |
HLA-DRB1
|
Cervix carcinoma
|
0.100 |
GeneticVariation |
BEFREE |
We also confirmed previously reported associations of B*0702 and DRB1*1501-DQB1*0602 with susceptibility to and DRB1*1301-DQA1*0103-DQB1*0603 with protection against cervical cancer.
|
23482656 |
2013 |