Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 6556
Gene Symbol: SLC11A1
SLC11A1
CUI: C0041327
Disease: Tuberculosis, Pulmonary
Tuberculosis, Pulmonary
0.100 Biomarker BEFREE A stratified analysis by ethnicity revealed that the NRAMP1 3'UTR polymorphism was associated with an increased risk of PTB in the Asian population, but not in Caucasian, African, and South American populations.The present results indicate that the NRAMP1 3'UTR polymorphism may be considered a risk factor for PTB in the Asian population. 31169721

2019

Entrez Id: 6556
Gene Symbol: SLC11A1
SLC11A1
CUI: C0041327
Disease: Tuberculosis, Pulmonary
Tuberculosis, Pulmonary
0.100 GeneticVariation BEFREE These data suggested that genetic variations in SLC11A1 may affect the incidence of MDR-TB and clinical features of pulmonary tuberculosis. 17950034

2008

Entrez Id: 6556
Gene Symbol: SLC11A1
SLC11A1
CUI: C0041327
Disease: Tuberculosis, Pulmonary
Tuberculosis, Pulmonary
0.100 GeneticVariation BEFREE These results suggest that variants in SLC11A1 increase susceptibility to pulmonary TB and interact with other variants that differ by race. 19723394

2009

Entrez Id: 6556
Gene Symbol: SLC11A1
SLC11A1
CUI: C0041327
Disease: Tuberculosis, Pulmonary
Tuberculosis, Pulmonary
0.100 GeneticVariation BEFREE This meta-analysis suggests that polymorphisms in the SLC11A1 gene contribute to TB (both PTB and EPTB), particularly in Asians. 22326178

2012

Entrez Id: 6556
Gene Symbol: SLC11A1
SLC11A1
CUI: C0041327
Disease: Tuberculosis, Pulmonary
Tuberculosis, Pulmonary
0.100 GeneticVariation BEFREE To investigate natural-resistance-associated macrophage protein 1 (NRAMP1), mannose-binding lectin (MBL), vitamin D receptor (VDR) gene polymorphisms and their interaction with susceptibility to pulmonary tuberculosis (PTB) in a Chinese population. 26261060

2015

Entrez Id: 6556
Gene Symbol: SLC11A1
SLC11A1
CUI: C0041327
Disease: Tuberculosis, Pulmonary
Tuberculosis, Pulmonary
0.100 GeneticVariation BEFREE Homozygotes for the TGTG deletion (1729+55del4) in the 3'UTR of SLC11A1 were over-represented among PTB patients (P = 0.013; OR 5.19; 95% CI 1.42-18.94). 15636493

2004

Entrez Id: 6556
Gene Symbol: SLC11A1
SLC11A1
CUI: C0041327
Disease: Tuberculosis, Pulmonary
Tuberculosis, Pulmonary
0.100 GeneticVariation LHGDN Polymorphisms of D543N and 3'UTR locus in NRAMP1 gene might affect their susceptibility to TB in Chinese Han population. 14703493

2003

Entrez Id: 6556
Gene Symbol: SLC11A1
SLC11A1
CUI: C0041327
Disease: Tuberculosis, Pulmonary
Tuberculosis, Pulmonary
0.100 GeneticVariation LHGDN Polymorphisms in the VDR and NRAMP1 gene are statistically associated with susceptibility to PTB in the Chinese Han population. 15141734

2004

Entrez Id: 6556
Gene Symbol: SLC11A1
SLC11A1
CUI: C0041327
Disease: Tuberculosis, Pulmonary
Tuberculosis, Pulmonary
0.100 GeneticVariation BEFREE A significant association between pulmonary tuberculosis and a microsatellite marker in the 5'(CA)n locus in the SLC11A1 gene compared with controls (38% versus 30% odds ratio 1.45, 95% CI: 1.06-1.9, P=0.014) was observed. 17157384

2007

Entrez Id: 6556
Gene Symbol: SLC11A1
SLC11A1
CUI: C0041327
Disease: Tuberculosis, Pulmonary
Tuberculosis, Pulmonary
0.100 GeneticVariation BEFREE Heterozygote at 5'(GT)n, a dinucleotide repeat polymorphism in the promoter of NRAMP1, was observed at significantly higher frequencies among HIV-negative patients with pulmonary TB (41.6%; OR 2.02; 95%CI 1.11-3.64), extra-pulmonary TB (66.7%; OR 4.80; 95%CI 1.34-17.15), and HIV-seropositive TB patients (50%; OR 3.77; 95%CI 1.33-10.66) in comparison with the controls (27.8%). 12234138

2002

Entrez Id: 6556
Gene Symbol: SLC11A1
SLC11A1
CUI: C0041327
Disease: Tuberculosis, Pulmonary
Tuberculosis, Pulmonary
0.100 GeneticVariation BEFREE Polymorphisms in the VDR and NRAMP1 gene are statistically associated with susceptibility to PTB in the Chinese Han population. 15141734

2004

Entrez Id: 6556
Gene Symbol: SLC11A1
SLC11A1
CUI: C0041327
Disease: Tuberculosis, Pulmonary
Tuberculosis, Pulmonary
0.100 GeneticVariation BEFREE Based on comprehensive searches of the PubMed, Medline, Embase, Web of Science, Elsevier Science Direct and Cochrane Library database, we identified outcome data from all articles estimating the association between NRAMP1 polymorphisms and PTB risk. 28648687

2017

Entrez Id: 6556
Gene Symbol: SLC11A1
SLC11A1
CUI: C0041327
Disease: Tuberculosis, Pulmonary
Tuberculosis, Pulmonary
0.100 GeneticVariation LHGDN The findings of the present study support the hypothesis that genetic variants of NRAMP1 may have an effect on bacilli growth and on outcomes of pulmonary tuberculosis, but not on susceptibility to M. tuberculosis infection. 15825023

2005

Entrez Id: 6556
Gene Symbol: SLC11A1
SLC11A1
CUI: C0041327
Disease: Tuberculosis, Pulmonary
Tuberculosis, Pulmonary
0.100 GeneticVariation BEFREE This study aimed to determine the association of NRAMP1, VDR, and TNF-á variant with development of pulmonary tuberculosis (PTB) among Iranian patients. 20231985

2009

Entrez Id: 6556
Gene Symbol: SLC11A1
SLC11A1
CUI: C0041327
Disease: Tuberculosis, Pulmonary
Tuberculosis, Pulmonary
0.100 Biomarker BEFREE Since human genetic variation is an important determinant in the outcome of infection with M. tuberculosis, we typed polymorphisms in the innate immune molecules, such as natural-resistance-associated macrophage protein 1 (NRAMP1), Vitamin D receptor (VDR), Tumor necrosis factor alpha (TNF-α), intercellular adhesion molecule1 (ICAM-1), Toll-like receptor 2 (TLR2) and Toll-like receptor 4 (TLR4) in a case-control study of pulmonary tuberculosis in Iranian population. 26774366

2016

Entrez Id: 6556
Gene Symbol: SLC11A1
SLC11A1
CUI: C0041327
Disease: Tuberculosis, Pulmonary
Tuberculosis, Pulmonary
0.100 GeneticVariation BEFREE The aim of this study is to investigate the roles of AMs response-related genes TNF-alpha, iNOS, and NRAMP1 (SLC11A1) in susceptibility to silicosis and pulmonary tuberculosis (PTB), and to analyze the interaction of dust exposure and genetic susceptibility to silicosis, interactions of TNF-alpha-308 and Natural Resistance-associated Macrophage Protein 1 (NRAMP1) INT4, D543N polymorphisms to PTB. 17223386

2007

Entrez Id: 6556
Gene Symbol: SLC11A1
SLC11A1
CUI: C0041327
Disease: Tuberculosis, Pulmonary
Tuberculosis, Pulmonary
0.100 GeneticVariation LHGDN The aim of this study is to investigate the roles of AMs response-related genes TNF-alpha, iNOS, and NRAMP1 (SLC11A1) in susceptibility to silicosis and pulmonary tuberculosis (PTB), and to analyze the interaction of dust exposure and genetic susceptibility to silicosis, interactions of TNF-alpha-308 and Natural Resistance-associated Macrophage Protein 1 (NRAMP1) INT4, D543N polymorphisms to PTB. 17223386

2007

Entrez Id: 6556
Gene Symbol: SLC11A1
SLC11A1
CUI: C0041327
Disease: Tuberculosis, Pulmonary
Tuberculosis, Pulmonary
0.100 GeneticVariation LHGDN These data suggested that genetic variations in SLC11A1 may affect the incidence of MDR-TB and clinical features of pulmonary tuberculosis. 17950034

2008

Entrez Id: 6556
Gene Symbol: SLC11A1
SLC11A1
CUI: C0041327
Disease: Tuberculosis, Pulmonary
Tuberculosis, Pulmonary
0.100 GeneticVariation BEFREE Sequence-specific oligonucleotide hybridization and microsatellite analysis were used to type NRAMP1 polymorphisms in 410 adults (mean age, 34.7 years) with smear-positive pulmonary tuberculosis and 417 ethnically matched, healthy controls. 9486992

1998

Entrez Id: 6556
Gene Symbol: SLC11A1
SLC11A1
CUI: C0041327
Disease: Tuberculosis, Pulmonary
Tuberculosis, Pulmonary
0.100 GeneticVariation BEFREE The findings of the present study support the hypothesis that genetic variants of NRAMP1 may have an effect on bacilli growth and on outcomes of pulmonary tuberculosis, but not on susceptibility to M. tuberculosis infection. 15825023

2005

Entrez Id: 6556
Gene Symbol: SLC11A1
SLC11A1
CUI: C0041327
Disease: Tuberculosis, Pulmonary
Tuberculosis, Pulmonary
0.100 Biomarker BEFREE Although the most convincing results were observed for HLA-DR2 and NRAMP1 (or a closely linked gene) in pulmonary tuberculosis and leprosy subtypes and for a 10p13 locus in paucibacillary leprosy, the molecular basis of their effects remains to be established. 14610288

2003

Entrez Id: 6556
Gene Symbol: SLC11A1
SLC11A1
CUI: C0041327
Disease: Tuberculosis, Pulmonary
Tuberculosis, Pulmonary
0.100 GeneticVariation BEFREE Polymerase chain reaction and restriction fragment-length polymorphism analyses were used to type NRAMP1 polymorphisms in 95 patients with pulmonary tuberculosis and 90 controls. 12799146

2003

Entrez Id: 6556
Gene Symbol: SLC11A1
SLC11A1
CUI: C0041327
Disease: Tuberculosis, Pulmonary
Tuberculosis, Pulmonary
0.100 GeneticVariation BEFREE This study, the first to include evidence on 577G/A and INT4, reports a significant association between SLC11A1 gene variants and PTB with respect to susceptibility and subsequent disease progression in East India. 22008758

2011

Entrez Id: 6556
Gene Symbol: SLC11A1
SLC11A1
CUI: C0041327
Disease: Tuberculosis, Pulmonary
Tuberculosis, Pulmonary
0.100 GeneticVariation BEFREE NRAMP1 and VDR gene polymorphisms in susceptibility to pulmonary tuberculosis among Andhra Pradesh population in India: a case-control study. 28583097

2017

Entrez Id: 6556
Gene Symbol: SLC11A1
SLC11A1
CUI: C0041327
Disease: Tuberculosis, Pulmonary
Tuberculosis, Pulmonary
0.100 Biomarker BEFREE We examined this hypothesis in Indonesia by spoligotyping M. tuberculosis isolates recovered from 336 patients with pulmonary tuberculosis and typing the patients' SLC11A1 gene (formerly known as "NRAMP1"), which is involved in susceptibility to tuberculosis. 19863441

2009