Source: BEFREE

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 407040
Gene Symbol: MIR34A
MIR34A
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.100 Biomarker BEFREE Tumor suppressor miR-34a and let-7 miRNAs were upregulated by fractionated radiation in radiosensitive LNCaP (p53 positive) and PC3 (p53-null) cells indicating that radiation-induced miRNA expression may not be regulated by p53 alone. 22827214

2012
Entrez Id: 407040
Gene Symbol: MIR34A
MIR34A
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.100 Biomarker BEFREE Tumor suppressor miR-34a connects the p53 network with forkhead box protein 1 (FOXP1) and BCL2. 24232982

2014
Entrez Id: 407040
Gene Symbol: MIR34A
MIR34A
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.100 Biomarker BEFREE Tumor-suppressive miR-34a, a direct target of p53, has been shown to target several molecules of cell survival pathways. 24444609

2014
Entrez Id: 407040
Gene Symbol: MIR34A
MIR34A
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.100 Biomarker BEFREE Tumor incidence was significantly increased and tumor formation was significantly accelerated in mice transgenic for SmoA1 and lacking miR-34a. 25348795

2015
Entrez Id: 407040
Gene Symbol: MIR34A
MIR34A
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.100 Biomarker BEFREE Tumor suppressor miR-34a targets PD-L1 and functions as a potential immunotherapeutic target in acute myeloid leukemia. 25499621

2015
Entrez Id: 407040
Gene Symbol: MIR34A
MIR34A
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.100 Biomarker BEFREE Tumors from nude mice treated with miR-34a or CRT0066101 showed suppressed tumor growth, proliferation, and induced apoptosis. 26895471

2016
Entrez Id: 407040
Gene Symbol: MIR34A
MIR34A
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.100 Biomarker BEFREE Tumor suppressor miRNAs such as miR-34a inhibit tumor growth by simultaneously regulating the expression of multiple important oncogenes across multiple oncogenic pathways and, therefore, provide a strong rationale for developing therapeutic miRNA mimics in combination with other therapeutic cancer agents to augment drug sensitivity. 27924478

2017
Entrez Id: 407040
Gene Symbol: MIR34A
MIR34A
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.100 Biomarker BEFREE Tumor growth in xenografts as well as EGFR signaling were assessed in HCT116 cells expressing IL17RD with either a mutant 3' untranslated region (UTR) or wild-type (WT) 3'UTR.<b>Results:</b> miR-31, miR-34a, miR-106b, and miR-193a-3p were significantly dysregulated in ulcerative colitis-neoplasia and adjacent tissue. 28600480

2017
Entrez Id: 407040
Gene Symbol: MIR34A
MIR34A
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.100 Biomarker BEFREE Tumor suppressor miR-34a was induced upon MCT-1 knockdown that inhibited IL-6R expression and activated M1 polarization. 30885232

2019
Entrez Id: 407040
Gene Symbol: MIR34A
MIR34A
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.100 Biomarker BEFREE MicroRNA-34a functions as a potential tumor suppressor by inducing apoptosis in neuroblastoma cells. 17297439

2007
Entrez Id: 407040
Gene Symbol: MIR34A
MIR34A
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.100 AlteredExpression BEFREE miR-34a expression is decreased in 100%, and miR-34b*/c in 72%, of EOC with p53 mutation, whereas miR-34a is also downregulated in 93% of tumors with wild-type p53. 20145172

2010
Entrez Id: 407040
Gene Symbol: MIR34A
MIR34A
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.100 Biomarker BEFREE MicroRNA 34a (miR-34a) is a potential tumor suppressor gene and has been identified as a miRNA component of the p53 network. 21182263

2011
Entrez Id: 407040
Gene Symbol: MIR34A
MIR34A
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.100 AlteredExpression BEFREE MicroRNA-34a (miR-34a), a transcriptional target of p53, is a well-known tumor suppressor gene. 22198213

2012
Entrez Id: 407040
Gene Symbol: MIR34A
MIR34A
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.100 Biomarker BEFREE MicroRNA-34a (miR-34a) can function as a tumor suppressor in some cancers through negative regulation of gene expression. 22246523

2012
Entrez Id: 407040
Gene Symbol: MIR34A
MIR34A
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.100 Biomarker BEFREE miR-34a functions as an important tumor suppressor during the process of carcinogenesis. 22292433

2012
Entrez Id: 407040
Gene Symbol: MIR34A
MIR34A
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.100 Biomarker BEFREE MicroRNA-34a (miR-34a) as a tumor suppressor has been reported in many other studies. 23085450

2012
Entrez Id: 407040
Gene Symbol: MIR34A
MIR34A
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.100 Biomarker BEFREE miR-34a is transcriptionally induced by the tumor suppressor gene p53, which is often downregulated in non-small cell lung cancer (NSCLC). 23349340

2013
Entrez Id: 407040
Gene Symbol: MIR34A
MIR34A
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.100 Biomarker BEFREE MiR-34a is best known as a tumor suppressor through repression of growth factors and oncogenes. 24220341

2013
Entrez Id: 407040
Gene Symbol: MIR34A
MIR34A
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.100 Biomarker BEFREE MiR-34a and miR-483-5p are candidate serum biomarkers for distinguishing between benign and malignant adrenocortical tumors. 24238045

2013
Entrez Id: 407040
Gene Symbol: MIR34A
MIR34A
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.100 Biomarker BEFREE MiR-34a is a tumor suppressor that is frequently downregulated in a number of tumor types. 24370784

2014
Entrez Id: 407040
Gene Symbol: MIR34A
MIR34A
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.100 Biomarker BEFREE MiR-34a serves as a tumor suppressor in human glioma mainly by decreasing NOX2 expression. 24393844

2014
Entrez Id: 407040
Gene Symbol: MIR34A
MIR34A
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.100 AlteredExpression BEFREE MiR-34a is an important tumor suppressor whose expression is suppressed in cancer stem cells (CSCs), and re-expression of miR-34a is able to inhibit the tumorigenic activity of CSCs. 25173798

2014
Entrez Id: 407040
Gene Symbol: MIR34A
MIR34A
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.100 AlteredExpression BEFREE miR-34a expression in tumor tissues from TSCC patients with positive lymph node metastases was significantly lower than that with negative lymph node metastases. 25268950

2014
Entrez Id: 407040
Gene Symbol: MIR34A
MIR34A
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.100 Biomarker BEFREE MicroRNA-34a (miR-34a) has been reported to be downregulated in a number of tumor types and has also been shown to act as a tumor suppressor. 25333573

2015
Entrez Id: 407040
Gene Symbol: MIR34A
MIR34A
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.100 Biomarker BEFREE miR-34a is a member of the miR-34 family and acts as a tumor suppressor in bladder cancer. 25878394

2015