Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 101154753
Gene Symbol: PANDAR
PANDAR
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.060 AlteredExpression BEFREE Moreover, we discovered that high PANDAR expression was closely related to decreased OS in colorectal cancer (pooled HR 3.43, 95%CI 2.06-5.72) and reduced expression level of PANDAR was markedly related to poor OS (pooled HR 0.65, 95%CI 0.45-0.88) in non-small cell lung cancer. 31850222

2019

Entrez Id: 6615
Gene Symbol: SNAI1
SNAI1
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.100 Biomarker BEFREE 20(R)-Ginsenoside Rg3 Influences Cancer Stem Cell Properties and the Epithelial-Mesenchymal Transition in Colorectal Cancer via the SNAIL Signaling Axis. 31849492

2019

Entrez Id: 406937
Gene Symbol: MIR145
MIR145
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.100 Biomarker BEFREE The miR-145 mimics suppressed CRC cell invasion and migration significantly; in contrast, miR-145 downregulation had the opposite effect. 31849487

2019

Entrez Id: 7291
Gene Symbol: TWIST1
TWIST1
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.100 Biomarker BEFREE TWIST1 knockdown significantly inhibited the CRC cell migration ability and the number of CRC cells that crossed the Transwell membrane. 31849487

2019

Entrez Id: 54765
Gene Symbol: TRIM44
TRIM44
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.010 AlteredExpression BEFREE In vitro, we effectively silenced the expression of TRIM44 in CRC cell lines. 31849481

2019

Entrez Id: 6694
Gene Symbol: SPP2
SPP2
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.010 AlteredExpression BEFREE SPP2 was expressed at lower levels in colorectal cancer, leukemia, liver cancer and pancreatic cancer. 31849319

2019

Entrez Id: 354
Gene Symbol: KLK3
KLK3
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.040 GeneticVariation BEFREE Differences were detected in the completion of screening tests for colorectal cancer (p < 0.001), breast cancer (p = 0.023), cervical cancer (p = 0.006), and prostate-specific antigen determination (p < 0.001) in relation to the participants' academic profiles. 31848937

2019

Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.700 GeneticVariation BEFREE Patients with pancreatic adenocarcinoma and BRAF-mutant colorectal cancer (CRC) were enrolled in the expansion stage. 31848189

2020

Entrez Id: 3425
Gene Symbol: IDUA
IDUA
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.030 GeneticVariation BEFREE To fill this gap in knowledge, we developed a rapid and effective method to obtain and analyze IgG Fc N-glycopeptides in the plasma from 46 CRC patients and 67 healthy individuals using chitosan@poly (glycidyl methacrylate) @iminodiacetic acid (CS@PGMA@IDA) nanomaterial in combination with matrix-assisted laser desorption/ionization-time of flight mass spectrometry (MALDI-TOF-MS). 31846768

2020

Entrez Id: 2956
Gene Symbol: MSH6
MSH6
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.600 GeneticVariation BEFREE Colorectal cancer in Lynch syndrome associated with PMS2 and MSH6 mutations. 31845022

2020

Entrez Id: 5395
Gene Symbol: PMS2
PMS2
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.500 GeneticVariation BEFREE Colorectal cancer in Lynch syndrome associated with PMS2 and MSH6 mutations. 31845022

2020

Entrez Id: 4360
Gene Symbol: MRC1
MRC1
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.100 GeneticVariation BEFREE Lynch syndrome (LS) is responsible for 3-5% of CRCs and develops due to mutations in DNA mismatch repair (MMR) genes. 31845022

2020

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.700 GeneticVariation BEFREE Our studies provide compelling evidence CRCs utilizes glutamine to replenish the TCA cycle in vivo, suggesting that targeting glutamine metabolism could be a therapeutic approach for CRCs, especially for PIK3CA-mutant CRCs. 31844152

2019

Entrez Id: 29126
Gene Symbol: CD274
CD274
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.100 AlteredExpression BEFREE Triple blockade of EGFR, MEK and PD-L1 has antitumor activity in colorectal cancer models with constitutive activation of MAPK signaling and PD-L1 overexpression. 31842958

2019

Entrez Id: 835
Gene Symbol: CASP2
CASP2
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.060 Biomarker BEFREE Inhibition of caspase-2 by TRIM25 implies a survival mechanism that critically contributes to chemotherapeutic drug resistance in CRC. 31842382

2019

Entrez Id: 7706
Gene Symbol: TRIM25
TRIM25
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.020 Biomarker BEFREE Inhibition of caspase-2 by TRIM25 implies a survival mechanism that critically contributes to chemotherapeutic drug resistance in CRC. 31842382

2019

Entrez Id: 399
Gene Symbol: RHOH
RHOH
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.010 Biomarker BEFREE The novel mechanistic insights gleaned in this study suggest that combination therapy with TTFields and 5-FU may be effective in treating CRC, although safety and efficacy testing in patients with CRC will need to be performed before this strategy can be implemented clinically for TTF-sensitization. 31842288

2019

Entrez Id: 10112
Gene Symbol: KIF20A
KIF20A
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.010 Biomarker BEFREE KIF20A promotes cellular malignant behavior and enhances resistance to chemotherapy in colorectal cancer through regulation of the JAK/STAT3 signaling pathway. 31841120

2019

Entrez Id: 5105
Gene Symbol: PCK1
PCK1
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.010 Biomarker BEFREE Our findings provide a potential mechanistic basis for the epidemiologic association of anti-gluconeogenic drugs with improved CRC metastasis outcomes, reveal the exploitation of a gluconeogenesis enzyme for pyrimidine biosynthesis under hypoxia, and implicate DHODH and PCK1 as metabolic therapeutic targets in colorectal cancer metastatic progression. 31841108

2019

Entrez Id: 1723
Gene Symbol: DHODH
DHODH
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.010 Biomarker BEFREE Our findings provide a potential mechanistic basis for the epidemiologic association of anti-gluconeogenic drugs with improved CRC metastasis outcomes, reveal the exploitation of a gluconeogenesis enzyme for pyrimidine biosynthesis under hypoxia, and implicate DHODH and PCK1 as metabolic therapeutic targets in colorectal cancer metastatic progression. 31841108

2019

Entrez Id: 527
Gene Symbol: ATP6V0C
ATP6V0C
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.020 Biomarker BEFREE ATP6L promotes metastasis of colorectal cancer via inducing epithelial-mesenchymal transition. 31840304

2020

Entrez Id: 107
Gene Symbol: ADCY1
ADCY1
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.010 GeneticVariation BEFREE In recent years, investigations based on genetic sequencing have revealed the emerging role of ADCY1 mutations in affecting drug efficiency in various cancers such as lung cancer, esophageal cancer and colorectal cancer. 31839819

2019

Entrez Id: 6749
Gene Symbol: SSRP1
SSRP1
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.040 Biomarker BEFREE Therefore, this study explored the role of SSRP1 in the occurrence and development of colorectal cancer. 31839745

2019

Entrez Id: 494324
Gene Symbol: MIR375
MIR375
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.100 Biomarker BEFREE We also verified that METTL14 suppressed CRC cell growth via the miR-375/Yes-associated protein 1 (YAP1) pathway, as well as inhibited CRC cell migration and invasion through the miR-375/SP1 pathway. 31839484

2020

Entrez Id: 57721
Gene Symbol: METTL14
METTL14
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.010 Biomarker BEFREE Taken together, our studies showed an important role for METTL14 in CRC progression and provided novel insight into m6A modification in CRC progression. 31839484

2020