Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1
CUI: C0039263
Disease: Takayasu Arteritis
Takayasu Arteritis
0.090 GeneticVariation BEFREE Therefore, the combination or haplotype of HLA-Bw52-DRB1*1502-DRB5*0102-DQA1*0103-DQB1*0601 -DPA1*02-DPB1*0901 may confer susceptibility to Takayasu arteritis while another combination or haplotype of HLA-Bw54-DRB1*0405-DRB4*0101-DQA1*0301-DQB1++ +*0401 may confer resistance to the disease. 1350869

1992

Entrez Id: 129831
Gene Symbol: RBM45
RBM45
CUI: C0039263
Disease: Takayasu Arteritis
Takayasu Arteritis
0.060 GeneticVariation BEFREE Therefore, the combination or haplotype of HLA-Bw52-DRB1*1502-DRB5*0102-DQA1*0103-DQB1*0601 -DPA1*02-DPB1*0901 may confer susceptibility to Takayasu arteritis while another combination or haplotype of HLA-Bw54-DRB1*0405-DRB4*0101-DQA1*0301-DQB1++ +*0401 may confer resistance to the disease. 1350869

1992

Entrez Id: 3117
Gene Symbol: HLA-DQA1
HLA-DQA1
CUI: C0039263
Disease: Takayasu Arteritis
Takayasu Arteritis
0.040 GeneticVariation BEFREE Therefore, the combination or haplotype of HLA-Bw52-DRB1*1502-DRB5*0102-DQA1*0103-DQB1*0601 -DPA1*02-DPB1*0901 may confer susceptibility to Takayasu arteritis while another combination or haplotype of HLA-Bw54-DRB1*0405-DRB4*0101-DQA1*0301-DQB1++ +*0401 may confer resistance to the disease. 1350869

1992

Entrez Id: 3105
Gene Symbol: HLA-A
HLA-A
CUI: C0039263
Disease: Takayasu Arteritis
Takayasu Arteritis
0.040 GeneticVariation BEFREE Sixty-four patients with Takayasu arteritis and 317 healthy individuals in the Japanese population were examined for HLA-A, -B and -C alleles by serological typing and for HLA-DR, DQ and DP alleles by DNA typing using PCR/SSOP analysis. 1350869

1992

Entrez Id: 3115
Gene Symbol: HLA-DPB1
HLA-DPB1
CUI: C0039263
Disease: Takayasu Arteritis
Takayasu Arteritis
0.030 GeneticVariation BEFREE Because this is the first evidence for the association between an HLA-DP allele and Takayasu arteritis, we examined the nucleotide sequences of the DPB1*0901 allele from a patient and her healthy relatives and found no difference. 1350869

1992

Entrez Id: 3113
Gene Symbol: HLA-DPA1
HLA-DPA1
CUI: C0039263
Disease: Takayasu Arteritis
Takayasu Arteritis
0.010 GeneticVariation BEFREE Therefore, the combination or haplotype of HLA-Bw52-DRB1*1502-DRB5*0102-DQA1*0103-DQB1*0601 -DPA1*02-DPB1*0901 may confer susceptibility to Takayasu arteritis while another combination or haplotype of HLA-Bw54-DRB1*0405-DRB4*0101-DQA1*0301-DQB1++ +*0401 may confer resistance to the disease. 1350869

1992

Entrez Id: 3105
Gene Symbol: HLA-A
HLA-A
CUI: C0039263
Disease: Takayasu Arteritis
Takayasu Arteritis
0.040 Biomarker BEFREE The HLA-A, B, DR and MB antigens were investigated in patients suffering from Takayasu disease (Aortitis syndrome). 6120922

1982

Entrez Id: 3106
Gene Symbol: HLA-B
HLA-B
CUI: C0039263
Disease: Takayasu Arteritis
Takayasu Arteritis
0.500 GeneticVariation BEFREE Because two HLA-B alleles, HLA-B51 and B39.1, which are similar but different at the epitope from HLA-B52 and B39.2, respectively, are not associated with Takayasu arteritis, 63Glu and 67Ser are supposed to be involved in the pathogenesis. 7903491

1993

Entrez Id: 3106
Gene Symbol: HLA-B
HLA-B
CUI: C0039263
Disease: Takayasu Arteritis
Takayasu Arteritis
0.500 Biomarker BEFREE Comparison of amino acid sequences of these disease-associated HLA-B alleles identified critical amino acid residues of the HLA-B molecule, Glu and Ser at 63rd and 67th positions, respectively, which may determine the susceptibility to Takayasu's arteritis via binding and presenting a yet unknown disease-related antigen. 9119528

1996

Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1
CUI: C0039263
Disease: Takayasu Arteritis
Takayasu Arteritis
0.090 GeneticVariation BEFREE Takayasu arteritis in Mexicans is probably associated with the HLA-DR6 (DRB1*1301) gene. 9248846

1996

Entrez Id: 129831
Gene Symbol: RBM45
RBM45
CUI: C0039263
Disease: Takayasu Arteritis
Takayasu Arteritis
0.060 GeneticVariation BEFREE Takayasu arteritis in Mexicans is probably associated with the HLA-DR6 (DRB1*1301) gene. 9248846

1996

Entrez Id: 3329
Gene Symbol: HSPD1
HSPD1
CUI: C0039263
Disease: Takayasu Arteritis
Takayasu Arteritis
0.020 AlteredExpression BEFREE Although the immunohistochemical data were consistent with an ordinary atherosclerotic aortic aneurysm, in which TCR Valpha-Vbeta gene usage is known to be polyclonal, the restricted TCR gene usage suggests that a certain autoimmune mechanism was involved in the pathogenesis of this case similar to Takayasu's arteritis, in which massive infiltration of delta T lymphocytes and strong expression of HSP-65 in the aortic tissue are characteristic. 9754895

1998

Entrez Id: 6962
Gene Symbol: TRBV20OR9-2
TRBV20OR9-2
CUI: C0039263
Disease: Takayasu Arteritis
Takayasu Arteritis
0.010 Biomarker BEFREE Although the immunohistochemical data were consistent with an ordinary atherosclerotic aortic aneurysm, in which TCR Valpha-Vbeta gene usage is known to be polyclonal, the restricted TCR gene usage suggests that a certain autoimmune mechanism was involved in the pathogenesis of this case similar to Takayasu's arteritis, in which massive infiltration of delta T lymphocytes and strong expression of HSP-65 in the aortic tissue are characteristic. 9754895

1998

Entrez Id: 100507436
Gene Symbol: MICA
MICA
CUI: C0039263
Disease: Takayasu Arteritis
Takayasu Arteritis
0.030 Biomarker BEFREE It was found that MICA-1.2 gave a significantly high OR of risk to Takayasu's arteritis in the absence of HLA-B52, suggesting that the HLA-linked gene susceptible to Takayasu's arteritis is mapped near the MICA gene. 9951809

1998

Entrez Id: 3106
Gene Symbol: HLA-B
HLA-B
CUI: C0039263
Disease: Takayasu Arteritis
Takayasu Arteritis
0.500 Biomarker BEFREE Thus HLA-B molecule may play an important role in pathogenesis or determining clinical manifestations of Takayasu arteritis. 9951811

1998

Entrez Id: 3111
Gene Symbol: HLA-DOA
HLA-DOA
CUI: C0039263
Disease: Takayasu Arteritis
Takayasu Arteritis
0.010 Biomarker BEFREE HLA-DNA typing using PCR-SSOP and PCR-DCP methods was performed in 85 patients with Takayasu arteritis and 492 healthy controls who had been typed for HLA by serological method. 9951811

1998

Entrez Id: 3105
Gene Symbol: HLA-A
HLA-A
CUI: C0039263
Disease: Takayasu Arteritis
Takayasu Arteritis
0.040 Biomarker BEFREE The distribution of HLA-A, B, C and DR antigens was determined in a cohort of 104 unrelated Indian patients with Takayasu arteritis (TA) belonging to the North Indian states of Punjab, Haryana, Uttar Pradesh and Delhi. 9951812

1998

Entrez Id: 3106
Gene Symbol: HLA-B
HLA-B
CUI: C0039263
Disease: Takayasu Arteritis
Takayasu Arteritis
0.500 GeneticVariation BEFREE Interestingly, HLA-B*39061 and B-39062 share the 3' end of intron 2 and the 5' end of exon 3 with HLA-B*5101 and B*52012, alleles associated to Takayasu arteritis in Japanese. 9951813

1998

Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1
CUI: C0039263
Disease: Takayasu Arteritis
Takayasu Arteritis
0.090 Biomarker BEFREE Takayasu arteritis is an uncommon condition in Mexican Mestizo, however, previous studies report association of the disease in this population with Human Leukocyte Antigen (HLA)-B39 and HLA-DRB1*1301. 9951813

1998

Entrez Id: 2153
Gene Symbol: F5
F5
CUI: C0039263
Disease: Takayasu Arteritis
Takayasu Arteritis
0.010 Biomarker BEFREE We report the first case of TA associated with the Factor V Leiden gene defect (Activated Protein C Resistance). 10072118

1999

Entrez Id: 5196
Gene Symbol: PF4
PF4
CUI: C0039263
Disease: Takayasu Arteritis
Takayasu Arteritis
0.010 AlteredExpression BEFREE Investigations of the thrombotic nature of Takayasu's arteritis have shown elevated levels of B-thromboglobulin, platelet factor 4, thrombin-antithrombin III complex, and fibrinopeptide A. 10072118

1999

Entrez Id: 3106
Gene Symbol: HLA-B
HLA-B
CUI: C0039263
Disease: Takayasu Arteritis
Takayasu Arteritis
0.500 GeneticVariation BEFREE Combined analyses of polymorphisms in the HLA-B and MICA genes with those in the microsatellites suggest that there are two different disease-susceptible loci for Takayasu's arteritis; one is mapped near the C1-2-A locus and the other is more closely linked to the HLA-B gene than to the MICA gene, because there are at least two different disease-associated HLA-B haplotypes, HLA-B*52 and -B*39.2 haplotypes, in which the disease-associated C1-2-A allele is shared in common. 10980346

2000

Entrez Id: 100507436
Gene Symbol: MICA
MICA
CUI: C0039263
Disease: Takayasu Arteritis
Takayasu Arteritis
0.030 GeneticVariation BEFREE Combined analyses of polymorphisms in the HLA-B and MICA genes with those in the microsatellites suggest that there are two different disease-susceptible loci for Takayasu's arteritis; one is mapped near the C1-2-A locus and the other is more closely linked to the HLA-B gene than to the MICA gene, because there are at least two different disease-associated HLA-B haplotypes, HLA-B*52 and -B*39.2 haplotypes, in which the disease-associated C1-2-A allele is shared in common. 10980346

2000

Entrez Id: 3106
Gene Symbol: HLA-B
HLA-B
CUI: C0039263
Disease: Takayasu Arteritis
Takayasu Arteritis
0.500 GeneticVariation BEFREE The association of Takayasu arteritis with Amerindian and Asian HLA-DRB1 alleles (DRB1*1602 and DRB1*1001) in the Colombian mestizo patients reported here, and with HLA-B*3906 previously reported in Mexicans, suggest the possibility that some HLA and disease associations are markers for ethnicity of a population carrying a disease gene which is present in an admixed population with the disease. 10980348

2000

Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1
CUI: C0039263
Disease: Takayasu Arteritis
Takayasu Arteritis
0.090 GeneticVariation BEFREE The association of Takayasu arteritis with Amerindian and Asian HLA-DRB1 alleles (DRB1*1602 and DRB1*1001) in the Colombian mestizo patients reported here, and with HLA-B*3906 previously reported in Mexicans, suggest the possibility that some HLA and disease associations are markers for ethnicity of a population carrying a disease gene which is present in an admixed population with the disease. 10980348

2000