Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 9734
Gene Symbol: HDAC9
HDAC9
CUI: C0039263
Disease: Takayasu Arteritis
Takayasu Arteritis
0.010 GeneticVariation BEFREE Takayasu arteritis risk locus in <i>IL6</i> might increase disease susceptibility by suppression of the anti-inflammatory gene <i>GPNMB</i> through chromatin looping and recruitment of MEF2-HDAC epigenetic repressive complex. 31315839

2019

Entrez Id: 1116
Gene Symbol: CHI3L1
CHI3L1
CUI: C0039263
Disease: Takayasu Arteritis
Takayasu Arteritis
0.010 Biomarker BEFREE Serum YKL-40 concentrations may be a useful biomarker of disease activity in TA. 31303395

2019

Entrez Id: 3920
Gene Symbol: LAMP2
LAMP2
CUI: C0039263
Disease: Takayasu Arteritis
Takayasu Arteritis
0.010 AlteredExpression BEFREE Both serum PTX-3 and LAMP-2 levels were elevated in TAK patients compared with those in healthy controls (PTX- 3: 0.32±0.03 ng/ml vs. 0.18±0.02 ng/ ml, p=0.001; LAMP-2: 4.40±0.14 ng/ ml vs. 3.30±0.20 ng/ml, p<0.001). 30943132

2019

Entrez Id: 4205
Gene Symbol: MEF2A
MEF2A
CUI: C0039263
Disease: Takayasu Arteritis
Takayasu Arteritis
0.010 GeneticVariation BEFREE We revealed preferential recruitment of myocyte enhancer factor 2-histone deacetylase (MEF2-HDAC) repressive complex to the Takayasu arteritis risk allele. 31315839

2019

Entrez Id: 6283
Gene Symbol: S100A12
S100A12
CUI: C0039263
Disease: Takayasu Arteritis
Takayasu Arteritis
0.010 AlteredExpression BEFREE Induction with LPS led to increase in secretion of both S100A8/A9 and S100A12 levels in TA as well as healthy controls. 30594066

2019

Entrez Id: 10272
Gene Symbol: FSTL3
FSTL3
CUI: C0039263
Disease: Takayasu Arteritis
Takayasu Arteritis
0.010 Biomarker BEFREE Considering this, we further built a logistic regression model based on multiple cytokines, including CA (cancer antigen) 125, FLRG (follistatin-related protein), IGFBP (insulin-like growth factor-binding protein)-2, CA15-3, GROa (growth-regulated alpha protein), LYVE (lymphatic vessel endothelial hyaluronic acid receptor)-1, ULBP (UL16-binding protein)-2, and CD (cluster of differentiation) 99, with an area under the curve reaching 0.909 for discriminating TA activity status. 30645172

2019

Entrez Id: 3146
Gene Symbol: HMGB1
HMGB1
CUI: C0039263
Disease: Takayasu Arteritis
Takayasu Arteritis
0.010 AlteredExpression BEFREE Among the subsets of VAs, serum HMGB1 levels were significantly higher in AAV, polyarteritis nodosa (PAN) and takayasu arteritis (TA) than in HC (all P < .05). 30732222

2019

Entrez Id: 3952
Gene Symbol: LEP
LEP
CUI: C0039263
Disease: Takayasu Arteritis
Takayasu Arteritis
0.010 Biomarker BEFREE Leptin is a potential biomarker for assessing TA structural progression. 31595672

2019

Entrez Id: 7076
Gene Symbol: TIMP1
TIMP1
CUI: C0039263
Disease: Takayasu Arteritis
Takayasu Arteritis
0.010 Biomarker BEFREE This study suggested TIMP-1 as a specific biomarker for TA diagnosis with a cutoff value of 221.86 μg/L. 30645172

2019

Entrez Id: 284
Gene Symbol: ANGPT1
ANGPT1
CUI: C0039263
Disease: Takayasu Arteritis
Takayasu Arteritis
0.010 Biomarker BEFREE To investigate serum levels of a panel of angiogenic inducers (VEGF, FGF-2, Angiopoietin 1, -2, soluble VCAM-1) and inhibitors (angiostatin, endostatin, pentraxin-3) in patients with giant cell arteritis (GCA) and Takayasu's arteritis (TAK), in order to gain further insights into the molecular mechanisms driving angiogenesis dysregulation in large-vessel vasculitis (LVV). 31573481

2019

Entrez Id: 3447
Gene Symbol: IFNA13
IFNA13
CUI: C0039263
Disease: Takayasu Arteritis
Takayasu Arteritis
0.010 Biomarker BEFREE <i>Aim</i>: To investigate the relation between polymorphisms in the interleukin 10 (<i>IL</i>)-<i>10</i>, tumor necrosis factor (<i>TNF)</i>-α, transforming growth factor (<i>TGF)-</i>β and interferon (<i>IFN)-γ</i> genes and Takayasu's arteritis in the Mexican population. 31816847

2019

Entrez Id: 80781
Gene Symbol: COL18A1
COL18A1
CUI: C0039263
Disease: Takayasu Arteritis
Takayasu Arteritis
0.010 Biomarker BEFREE To investigate serum levels of a panel of angiogenic inducers (VEGF, FGF-2, Angiopoietin 1, -2, soluble VCAM-1) and inhibitors (angiostatin, endostatin, pentraxin-3) in patients with giant cell arteritis (GCA) and Takayasu's arteritis (TAK), in order to gain further insights into the molecular mechanisms driving angiogenesis dysregulation in large-vessel vasculitis (LVV). 31573481

2019

Entrez Id: 3439
Gene Symbol: IFNA1
IFNA1
CUI: C0039263
Disease: Takayasu Arteritis
Takayasu Arteritis
0.010 Biomarker BEFREE <i>Aim</i>: To investigate the relation between polymorphisms in the interleukin 10 (<i>IL</i>)-<i>10</i>, tumor necrosis factor (<i>TNF)</i>-α, transforming growth factor (<i>TGF)-</i>β and interferon (<i>IFN)-γ</i> genes and Takayasu's arteritis in the Mexican population. 31816847

2019

Entrez Id: 177
Gene Symbol: AGER
AGER
CUI: C0039263
Disease: Takayasu Arteritis
Takayasu Arteritis
0.010 AlteredExpression BEFREE The mRNA expression of S100A8, S100A9, S100A12 and TLR4 were higher, while expression of RAGE and HSP70 were lower in TA as compared to healthy controls. 30594066

2019

Entrez Id: 147719
Gene Symbol: LYPD4
LYPD4
CUI: C0039263
Disease: Takayasu Arteritis
Takayasu Arteritis
0.010 Biomarker BEFREE There was an increased mortality in TA (SMR with 95% confidence interval, 2.73 [1.69-4.22]) as compared to age and sex matched healthy controls. 30122419

2019

Entrez Id: 3308
Gene Symbol: HSPA4
HSPA4
CUI: C0039263
Disease: Takayasu Arteritis
Takayasu Arteritis
0.010 AlteredExpression BEFREE The mRNA expression of S100A8, S100A9, S100A12 and TLR4 were higher, while expression of RAGE and HSP70 were lower in TA as compared to healthy controls. 30594066

2019

Entrez Id: 7099
Gene Symbol: TLR4
TLR4
CUI: C0039263
Disease: Takayasu Arteritis
Takayasu Arteritis
0.010 AlteredExpression BEFREE Aim of this study was to examine the expression of TLR4 and its endogenous ligands in peripheral blood mononuclear cells (PBMCs) of patients with Takayasu arteritis (TA). 30594066

2019

Entrez Id: 5891
Gene Symbol: MOK
MOK
CUI: C0039263
Disease: Takayasu Arteritis
Takayasu Arteritis
0.010 AlteredExpression BEFREE The mRNA expression of S100A8, S100A9, S100A12 and TLR4 were higher, while expression of RAGE and HSP70 were lower in TA as compared to healthy controls. 30594066

2019

Entrez Id: 2919
Gene Symbol: CXCL1
CXCL1
CUI: C0039263
Disease: Takayasu Arteritis
Takayasu Arteritis
0.010 Biomarker BEFREE Considering this, we further built a logistic regression model based on multiple cytokines, including CA (cancer antigen) 125, FLRG (follistatin-related protein), IGFBP (insulin-like growth factor-binding protein)-2, CA15-3, GROa (growth-regulated alpha protein), LYVE (lymphatic vessel endothelial hyaluronic acid receptor)-1, ULBP (UL16-binding protein)-2, and CD (cluster of differentiation) 99, with an area under the curve reaching 0.909 for discriminating TA activity status. 30645172

2019

Entrez Id: 3627
Gene Symbol: CXCL10
CXCL10
CUI: C0039263
Disease: Takayasu Arteritis
Takayasu Arteritis
0.010 Biomarker BEFREE Significant differences in the levels of IL-1RA, IL-10, GM-CSF, eotaxin, and IP-10 were observed between the HD-TAK and HD-GCA groups. 30679579

2019

Entrez Id: 213
Gene Symbol: ALB
ALB
CUI: C0039263
Disease: Takayasu Arteritis
Takayasu Arteritis
0.010 Biomarker BEFREE RESULTS In patients with Takayasu arteritis, the erythrocyte sedimentation rate (ESR), CRP, CRP/albumin ratio, red cell distribution width (RDW), neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), and monocyte-lymphocyte ratio (MLR) were significantly higher, and albumin and MPV were significantly lower compared with controls. 30792377

2019

Entrez Id: 6774
Gene Symbol: STAT3
STAT3
CUI: C0039263
Disease: Takayasu Arteritis
Takayasu Arteritis
0.010 Biomarker BEFREE Additionally, phosphorylation of JAK2, STAT3 and Akt was significantly enhanced both in IL-6/IL-6R-treated AAFs in vitro and in TAK adventitial α-SMA positive cells. 28770707

2018

Entrez Id: 3605
Gene Symbol: IL17A
IL17A
CUI: C0039263
Disease: Takayasu Arteritis
Takayasu Arteritis
0.010 Biomarker BEFREE Although no definite boundaries exist, it may be suggested that the IL-6/Th17/IL-17 pathway primarily drives systemic inflammation while the IL-12/Th1/IFN-γ pathway dominates in vascular wall inflammation both in TAK and giant cell arteritis. 28968895

2018

Entrez Id: 84790
Gene Symbol: TUBA1C
TUBA1C
CUI: C0039263
Disease: Takayasu Arteritis
Takayasu Arteritis
0.010 AlteredExpression BEFREE Anti-tubulin-α-1c antibody levels were further determined by enzyme-linked immunosorbent assay (ELISA) in sera of patients with BD, systemic lupus erythematosus (SLE), recurrent aphthous ulcers (RAU), ANCA associated systemic vasculitis (AASV), Takayasu's arteritis (TA) and 59 healthy controls. 29902281

2018

Entrez Id: 3717
Gene Symbol: JAK2
JAK2
CUI: C0039263
Disease: Takayasu Arteritis
Takayasu Arteritis
0.010 Biomarker BEFREE IL-6/IL-6R induces fibrogenesis of AAFs via the JAK2/STAT3 and JAK2/Akt pathways, which provides theoretical evidence for IL-6 as a treatment target in TAK. 28770707

2018