Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1666
Gene Symbol: DECR1
DECR1
Diabetes Mellitus, Non-Insulin-Dependent
0.100 AlteredExpression BEFREE NADPH oxidase (p22(phox)) and HO-1 gene expression were probed by RT-PCR using leucocytes from patients with Type 2 diabetes without (n = 19) and with microangiopathy (n = 20) and non-diabetic subjects (n = 17). 16759310

2006

Entrez Id: 1666
Gene Symbol: DECR1
DECR1
Diabetes Mellitus, Non-Insulin-Dependent
0.100 Biomarker BEFREE Patients were genotyped for ROS-scavenging enzymes, Glutathione peroxidase-1 (GPx-1), Catalase, Mn-SOD, Cu/Zn-SOD, as well as SNPs of NADPH oxidase as ROS-promoting elements, genes related to onset of T2D (CAPN10, ADRB3, PPAR gamma, FATP4). 17825092

2007

Entrez Id: 1666
Gene Symbol: DECR1
DECR1
Diabetes Mellitus, Non-Insulin-Dependent
0.100 AlteredExpression BEFREE Augmented NADPH oxidase activity and p22phox expression in monocytes underlie oxidative stress of patients with type 2 diabetes mellitus. 21237524

2011

Entrez Id: 1666
Gene Symbol: DECR1
DECR1
Diabetes Mellitus, Non-Insulin-Dependent
0.100 GeneticVariation BEFREE The aim of this study was to examine the role of the NADPH oxidase C242T polymorphism in the development of carotid atherosclerosis in patients with type 2 diabetes. 22932942

2012

Entrez Id: 1666
Gene Symbol: DECR1
DECR1
Diabetes Mellitus, Non-Insulin-Dependent
0.100 AlteredExpression BEFREE Short-term intravenous insulin infusion is associated with reduced expression of NADPH oxidase p47(phox) subunit in monocytes from type 2 diabetes patients. 22780425

2013

Entrez Id: 1666
Gene Symbol: DECR1
DECR1
Diabetes Mellitus, Non-Insulin-Dependent
0.100 Biomarker BEFREE In conclusion, mechanisms of T2DM-associated ED in the human penis may involve uncoupled eNOS and nNOS and NADPH oxidase upregulation. 28076881

2017

Entrez Id: 1666
Gene Symbol: DECR1
DECR1
Diabetes Mellitus, Non-Insulin-Dependent
0.100 AlteredExpression BEFREE Furthermore, an interplay between ER stress and NADPH oxidase activity contributes to ROS production and may be a mechanism mediating endothelial cell adhesion and foam cell formation in T2D. 27859785

2017

Entrez Id: 1666
Gene Symbol: DECR1
DECR1
Diabetes Mellitus, Non-Insulin-Dependent
0.100 AlteredExpression BEFREE Our previous studies indicated that argirein which was developed by combining rhein with L-arginine by a hydrogen bond, could substantially relieved stress related exacerbation of cardiac failure and alleviated cardiac dysfunction in T2DM, which was associated with suppressing NADPH oxidase activity. 29709706

2018

Entrez Id: 1666
Gene Symbol: DECR1
DECR1
Diabetes Mellitus, Non-Insulin-Dependent
0.100 Biomarker BEFREE It has been proposed that pancreatic beta-cell dysfunction in type 2 diabetes is promoted by oxidative stress caused by NADPH oxidase (Nox) over-activity. 30265686

2018

Entrez Id: 1666
Gene Symbol: DECR1
DECR1
Diabetes Mellitus, Non-Insulin-Dependent
0.100 Biomarker BEFREE Here, we investigated whether argirein medication attenuated the vascular dysfunction in T2DM by inhibiting endothelial cell apoptosis which was associated with NADPH oxidase. 30135489

2018

Entrez Id: 1666
Gene Symbol: DECR1
DECR1
Diabetes Mellitus, Non-Insulin-Dependent
0.100 Biomarker BEFREE Misfolded toxic human islet amyloid polypeptide or amylin (hA) and plasma membrane-associated redox complex, NADPH oxidase (NOX), have been implicated in the islet β-cell demise associated with type-2 diabetes mellitus (T2DM). 29627323

2018

Entrez Id: 1666
Gene Symbol: DECR1
DECR1
Diabetes Mellitus, Non-Insulin-Dependent
0.100 Biomarker BEFREE We hypothesized that superoxide scavenging or NADPH oxidase inhibition would improve cutaneous vasodilation in older adults exercising in the heat, particularly in healthy low-fit individuals and those with type 2 diabetes. 31199960

2019