Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
CUI: C0302592
Disease: Cervix carcinoma
Cervix carcinoma
0.100 Biomarker BEFREE In this study, we used immunohistochemistry, single strand confirmation polymorphism (SSCP) and direct sequencing methods to analyze the mutation and protein expressions of both CTNNB1 and AXIN1 in cervical cancer. 12883680

2004

Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
CUI: C0302592
Disease: Cervix carcinoma
Cervix carcinoma
0.100 Biomarker BEFREE Our previous study showed that LGR5 functions as a tumor promoter in cervical cancer by activating the Wnt/β-catenin pathway. 28880275

2017

Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
CUI: C0302592
Disease: Cervix carcinoma
Cervix carcinoma
0.100 AlteredExpression BEFREE Several mRNAs, such as those encoding guanine nucleotide-binding protein Gs (alpha subunit), leukocyte adhesion protein (LFA1-beta), nuclear factor NF45, homeobox protein Hox-A1, and beta-catenin were detected in increased levels in cervical cancer. 9865919

1998

Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
CUI: C0302592
Disease: Cervix carcinoma
Cervix carcinoma
0.100 AlteredExpression BEFREE Furthermore, we also found that miR-4524b-5p could regulate the migration and invasion of cervical cancer by targeting WTX and that WTX could regulate the expression of β-catenin. 30939162

2019

Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
CUI: C0302592
Disease: Cervix carcinoma
Cervix carcinoma
0.100 Biomarker BEFREE Our study suggests that tigecycline is a useful addition to the treatment armamentarium for cervical cancer and targeting Wnt/β-catenin represents a potential therapeutic strategy in cervical cancer. 26427870

2015

Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
CUI: C0302592
Disease: Cervix carcinoma
Cervix carcinoma
0.100 Biomarker BEFREE This research unveiled the function of DEK in tumorigenesis and metastasis via the DEK/p-Ser9-GSK-3β/p-Tyr216-GSK-3β/β-catenin axis in cervical cancer and gave insights into DEK-targeting therapy for patients suffering from cervical cancer. 28627610

2017

Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
CUI: C0302592
Disease: Cervix carcinoma
Cervix carcinoma
0.100 GeneticVariation BEFREE Our findings indicate that alterations of beta-catenin are frequent in these tumors and suggest that they may play an important role in the development of cancer of the uterine cervix. 11893906

2002

Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
CUI: C0302592
Disease: Cervix carcinoma
Cervix carcinoma
0.100 AlteredExpression BEFREE Our work identifies MNK-eIF4E axis as a specific and critical regulator of β-catenin activity in cervical cancer but not normal cervical cells, and suggests that targeting MNK is a useful therapeutic strategy in cervical cancer. 31327462

2019

Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
CUI: C0302592
Disease: Cervix carcinoma
Cervix carcinoma
0.100 Biomarker BEFREE Chibby and β-catenin were analyzed for possible association with the progression of cervical cancer. 29181101

2017

Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
CUI: C0302592
Disease: Cervix carcinoma
Cervix carcinoma
0.100 GeneticVariation BEFREE The PIK3CA E542K and E545K mutations promote glycolysis and proliferation via induction of the β-catenin/SIRT3 signaling pathway in cervical cancer. 30547809

2018

Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
CUI: C0302592
Disease: Cervix carcinoma
Cervix carcinoma
0.100 Biomarker BEFREE Further investigations revealed that miR-433 inactivated AKT and β-catenin pathways in cervical cancer. 29130111

2017

Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
CUI: C0302592
Disease: Cervix carcinoma
Cervix carcinoma
0.100 AlteredExpression BEFREE α-Actinin-4 induces the epithelial-to-mesenchymal transition and tumorigenesis via regulation of Snail expression and β-catenin stabilization in cervical cancer. 27065319

2016

Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
CUI: C0302592
Disease: Cervix carcinoma
Cervix carcinoma
0.100 AlteredExpression BEFREE This is the first demonstration of overexpression of beta-catenin (also found in HPV-caused cervical cancer) in HPV-active OSCC. 19716018

2009

Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
CUI: C0302592
Disease: Cervix carcinoma
Cervix carcinoma
0.100 Biomarker BEFREE Taken together, our data demonstrate that EZH2 promotes cell proliferation and tumor formation in cervical cancer through activating the Wnt/β-catenin pathway by epigenetic silencing via GSK-3β and TP53. 27092879

2016

Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
CUI: C0302592
Disease: Cervix carcinoma
Cervix carcinoma
0.100 Biomarker BEFREE Activation of Wnt-β-catenin pathway in basal-parabasal layers of normal cervical epithelium comparable during development of uterine cervical carcinoma. 29079964

2018

Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
CUI: C0302592
Disease: Cervix carcinoma
Cervix carcinoma
0.100 AlteredExpression BEFREE Furthermore, we validated that GHET1 down-regulation could inactivate AKT/mTOR and Wnt/β-catenin pathways, and that respective activation of these two pathways abrogated the inhibitive effect of GHET1 knockdown on CC cell growth, migration and EMT. 31682716

2020

Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
CUI: C0302592
Disease: Cervix carcinoma
Cervix carcinoma
0.100 GeneticVariation BEFREE Targeting of β-catenin reverses radioresistance of cervical cancer with the PIK3CA E545K mutation. 31666350

2020

Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
CUI: C0302592
Disease: Cervix carcinoma
Cervix carcinoma
0.100 Biomarker BEFREE Together, our data demonstrated that SOX17 restrained the proliferation and tumor formation by down-regulating the activity of the Wnt/β-catenin signaling pathway via trans-suppression of β-catenin in cervical cancer. 29970906

2018

Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
CUI: C0302592
Disease: Cervix carcinoma
Cervix carcinoma
0.100 Biomarker BEFREE TRIM29 overexpression is associated with poor prognosis and promotes tumor progression by activating Wnt/β-catenin pathway in cervical cancer. 27081037

2016

Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
CUI: C0302592
Disease: Cervix carcinoma
Cervix carcinoma
0.100 Biomarker BEFREE These results demonstrate that ICAT contributed to the progression of cervical cancer and may play a role in the regulation of EMT by distrupting the E-cadherin/β-catenin complex. 29048651

2017

Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
CUI: C0302592
Disease: Cervix carcinoma
Cervix carcinoma
0.100 AlteredExpression BEFREE These suggest that overexpressions of MMP-2 and MT1-MMP, loss of TIMP-2 expression, and up-regulation of beta-catenin by AAC-11 transfection may contribute to the development of cervical cancer invasion. 10780674

2000

Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
CUI: C0302592
Disease: Cervix carcinoma
Cervix carcinoma
0.100 AlteredExpression BEFREE The expression of CRIP1 and β‑catenin in CC tissues was analyzed by immunohistochemistry (IHC). 29959029

2018

Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
CUI: C0302592
Disease: Cervix carcinoma
Cervix carcinoma
0.100 Biomarker BEFREE Inhibition of Wnt/beta-catenin pathway is an attractive method for therapy of various tumors including breast, colorectal, and cervical cancer, etc. 19857041

2010

Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
CUI: C0302592
Disease: Cervix carcinoma
Cervix carcinoma
0.100 Biomarker BEFREE Our findings demonstrate that eIF4E/β-catenin signaling plays a positive regulatory role in the resistance of cervical cancer cell to chemotherapy and thus highlight the therapeutic value of eIF4E or β-catenin inhibition in overcoming chemoresistance. 28386346

2017

Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
CUI: C0302592
Disease: Cervix carcinoma
Cervix carcinoma
0.100 Biomarker BEFREE WNT2 overexpression in cervical cancer was associated with β-catenin activation and induction of EMT, which further contributed to metastasis in cervical cancer. 27513465

2016