Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1312
Gene Symbol: COMT
COMT
CUI: C0338656
Disease: Impaired cognition
Impaired cognition
0.100 GeneticVariation BEFREE Psychosocial functioning and cognitive deficits are not associated with membrane-bound catechol-O-methyltransferase deoxyribonucleic acid methylation in siblings of patients with schizophrenia. 23124177

2012

Entrez Id: 1312
Gene Symbol: COMT
COMT
CUI: C0338656
Disease: Impaired cognition
Impaired cognition
0.100 GeneticVariation BEFREE The COMT Val158Val genotype and serological evidence of infection with HSV-1 are independent risk factors for cognitive impairment in individuals with bipolar disorder, particularly in the domains of immediate and delayed memory. 16542182

2006

Entrez Id: 1312
Gene Symbol: COMT
COMT
CUI: C0338656
Disease: Impaired cognition
Impaired cognition
0.100 AlteredExpression BEFREE Our findings suggest that the high-COMT activity haplotype is associated with cognitive decline in patients with PD. 29439855

2018

Entrez Id: 1312
Gene Symbol: COMT
COMT
CUI: C0338656
Disease: Impaired cognition
Impaired cognition
0.100 GeneticVariation BEFREE This study investigates whether genotypes associated with reduced prefrontal dopaminergic tone and/or reduced dopamine D2-receptor availability (Catechol-O-methyltransferase [COMT] Val<sup>158</sup> Met genotype and DRD2 C<sup>957</sup> T genotype) affect the development of cognitive deficits in PD. 28869277

2018

Entrez Id: 1312
Gene Symbol: COMT
COMT
CUI: C0338656
Disease: Impaired cognition
Impaired cognition
0.100 GeneticVariation BEFREE These findings suggest that GMV compromise in the early stages of PD may be a predisposing factor for cognitive decline of COMT Val/Val homozygotes. 30612340

2019

Entrez Id: 1312
Gene Symbol: COMT
COMT
CUI: C0338656
Disease: Impaired cognition
Impaired cognition
0.100 AlteredExpression BEFREE The aim of the present study was to better characterize the cognitive phenotype in a large cohort children with 22q11DS compared with sibling controls and to investigate if the cognitive deficits in 22q11DS were modulated by COMT expression. 20307169

2010

Entrez Id: 1312
Gene Symbol: COMT
COMT
CUI: C0338656
Disease: Impaired cognition
Impaired cognition
0.100 Biomarker BEFREE We conclude by outlining preliminary data indicating that COMT is a promising therapeutic target for ameliorating the cognitive deficits associated with schizophrenia. 16476412

2006

Entrez Id: 1312
Gene Symbol: COMT
COMT
CUI: C0338656
Disease: Impaired cognition
Impaired cognition
0.100 GeneticVariation BEFREE Factors such as age and genetic polymorphisms of apolipoprotein E, catechol-O-methyltransferase and BDNF may predispose individuals to a higher risk of cognitive impairment. 31617564

2019

Entrez Id: 1312
Gene Symbol: COMT
COMT
CUI: C0338656
Disease: Impaired cognition
Impaired cognition
0.100 Biomarker BEFREE Our finding are consistent with other studies showing genetic associations between the COMT and DAOA genes and impaired cognition both in psychiatric disorders and in the general population. 23861766

2013

Entrez Id: 1312
Gene Symbol: COMT
COMT
CUI: C0338656
Disease: Impaired cognition
Impaired cognition
0.100 Biomarker BEFREE Better understanding of the role of COMT in cognitive processes in AD, as well as integration of neurobiological, genetic, genomic and epigenetic data, might help in developing new potential therapies of cognitive impairments and psychotic symptoms, characteristic features of AD. 29231139

2018

Entrez Id: 1312
Gene Symbol: COMT
COMT
CUI: C0338656
Disease: Impaired cognition
Impaired cognition
0.100 AlteredExpression BEFREE These results confirm that sevoflurane has less effect on cognitive impairment than isoflurane, which may be related to expression of D1 dopamine receptors and catechol-O-methyltransferase and phosphorylation of glycogen synthase kinase-3β in the hippocampus. 31535657

2020

Entrez Id: 1312
Gene Symbol: COMT
COMT
CUI: C0338656
Disease: Impaired cognition
Impaired cognition
0.100 Biomarker BEFREE Treatment of cognitive deficits associated with schizophrenia: potential role of catechol-O-methyltransferase inhibitors. 17579498

2007

Entrez Id: 1312
Gene Symbol: COMT
COMT
CUI: C0338656
Disease: Impaired cognition
Impaired cognition
0.100 GeneticVariation BEFREE Two studies found a positive association between cognitive impairment and the Val allele of the COMT gene and the ε4 allele of the apolipoprotein E gene. 25458605

2014

Entrez Id: 1312
Gene Symbol: COMT
COMT
CUI: C0338656
Disease: Impaired cognition
Impaired cognition
0.100 Biomarker BEFREE Catechol-O-methyltransferase (COMT) plays a unique role in the regulation of dopamine in the prefrontal cortex, and has been implicated in the cognitive dysfunction evident in problem gambling. 26028545

2015

Entrez Id: 1312
Gene Symbol: COMT
COMT
CUI: C0338656
Disease: Impaired cognition
Impaired cognition
0.100 GeneticVariation BEFREE The investigation of the catechol-O-methyltransferase (COMT-[rs4680]) and methylenetetrahydrofolate reductase (MTHFR-[rs1801133]) polymorphisms' interaction might shed light into the pathogenetic mechanisms of the cognitive dysfunction in schizophrenia. 23353103

2013

Entrez Id: 1312
Gene Symbol: COMT
COMT
CUI: C0338656
Disease: Impaired cognition
Impaired cognition
0.100 GeneticVariation BEFREE While the high activity alleles of variants within COMT have been associated with cognitive deficits, and the low activity alleles with higher risk of anxiety disorders, no associations of COMT with PEs have been found. 24862404

2014

Entrez Id: 1312
Gene Symbol: COMT
COMT
CUI: C0338656
Disease: Impaired cognition
Impaired cognition
0.100 GeneticVariation BEFREE Our previous work has implicated two genetic factors in the development of cognitive dysfunction in Parkinson's disease, namely the genes for catechol-O-methyltransferase (COMT Val(158)Met) and microtubule-associated protein tau (MAPT) H1/H2. 19812213

2009

Entrez Id: 1312
Gene Symbol: COMT
COMT
CUI: C0338656
Disease: Impaired cognition
Impaired cognition
0.100 AlteredExpression BEFREE Genetic variation in D2 type DA receptors and the catechol-O-methyltransferase enzyme appears to moderate cognitive deficits induced by smoking abstinence. 20456288

2010

Entrez Id: 1312
Gene Symbol: COMT
COMT
CUI: C0338656
Disease: Impaired cognition
Impaired cognition
0.100 GeneticVariation BEFREE A single-nucleotide polymorphism in catechol-o-methyltransferase (COMT), an enzyme which degrades catecholamine neurotransmitters, may influence cognitive deficits following moderate and/or severe head trauma. 26576546

2016

Entrez Id: 1312
Gene Symbol: COMT
COMT
CUI: C0338656
Disease: Impaired cognition
Impaired cognition
0.100 GeneticVariation BEFREE To substantiate this existing gap, we comprehensively examine COMT genotype effects on the development of PD and test the hypothesis that the Met158 allele of the COMT gene is associated with cognitive dysfunction by conducting a meta-analysis review. 31354790

2019

Entrez Id: 1312
Gene Symbol: COMT
COMT
CUI: C0338656
Disease: Impaired cognition
Impaired cognition
0.100 Biomarker BEFREE In conclusion, in view of therapeutic efficacy, we can envisage indications for future investigations into the role of COMT for sleep regulation, cognitive performance and sleep-related cognitive deficits. 22483299

2012

Entrez Id: 1312
Gene Symbol: COMT
COMT
CUI: C0338656
Disease: Impaired cognition
Impaired cognition
0.100 Biomarker BEFREE Biomarkers, some longitudinal, predicting cognitive impairment in multivariable models were: (1) dopamine deficiency (decreased caudate and putamen DAT availability); (2) diffuse, cortical decreased brain volume or thickness (frontal, temporal, parietal, and occipital lobe regions); (3) co-morbid Alzheimer's disease Aβ amyloid pathology (lower CSF Aβ 1-42); and (4) genes (COMT val/val and BDNF val/val genotypes). 28520803

2017

Entrez Id: 1312
Gene Symbol: COMT
COMT
CUI: C0338656
Disease: Impaired cognition
Impaired cognition
0.100 GeneticVariation BEFREE Catechol-O-methyltransferase genotype modulates cancer treatment-related cognitive deficits in breast cancer survivors. 21425136

2011

Entrez Id: 1312
Gene Symbol: COMT
COMT
CUI: C0338656
Disease: Impaired cognition
Impaired cognition
0.100 GeneticVariation BEFREE This copy number variant results in haplo-insufficiency of the catechol-O-methyltransferase (COMT) gene, and is associated with a significant increase in the risk for developing cognitive impairments and psychosis. 30935427

2019

Entrez Id: 1312
Gene Symbol: COMT
COMT
CUI: C0338656
Disease: Impaired cognition
Impaired cognition
0.100 GeneticVariation BEFREE Allele G from COMT SNPs rs4680 and rs165599 may represent reliable state-dependent predictors of global CD during manic and mixed episodes in BD. 22713126

2012