Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 56729
Gene Symbol: RETN
RETN
CUI: C0948008
Disease: Ischemic stroke
Ischemic stroke
0.050 Biomarker BEFREE <b>Aim:</b> The association between adiponectin, leptin, and resistin and the long-term outcome of ischemic stroke are controversial.We aimed to evaluate this relationship. 30885017

2019

Entrez Id: 574501
Gene Symbol: MIR499A
MIR499A
CUI: C0948008
Disease: Ischemic stroke
Ischemic stroke
0.090 GeneticVariation BEFREE <b>Conclusion:</b> MiR-499 A>G (rs3746444) G allele and AG, AG + AA genotype might be risk factors of IS in Chinese. 29643803

2018

Entrez Id: 100128998
Gene Symbol: C20orf181
C20orf181
CUI: C0948008
Disease: Ischemic stroke
Ischemic stroke
0.100 Biomarker BEFREE <b>Conclusion:</b> Combination therapy with Danhong injection (4 mL/kg) plus t-PA (2.5 mg/kg) could extend the t-PA treatment time windows to 4.5 h, ameliorate BBB disruption, reduce infarction, brain swelling and hemorrhage after ischemic stroke. 29681849

2018

Entrez Id: 6774
Gene Symbol: STAT3
STAT3
CUI: C0948008
Disease: Ischemic stroke
Ischemic stroke
0.100 Biomarker BEFREE <b>Conclusion:</b> EGB is demonstrated to mediate neuroinflammation, which protects against ischemic brain injury by inhibiting astrogliosis and suppresses neuroinflammation via the LCN2-JAK2/STAT3 pathway, providing insight into a promising therapeutic strategy for ischemic stroke. 29867513

2018

Entrez Id: 54
Gene Symbol: ACP5
ACP5
CUI: C0948008
Disease: Ischemic stroke
Ischemic stroke
0.010 AlteredExpression BEFREE <b>Conclusion:</b> IncRNA-H19 promoting ACP5 protein expression contributed to atherosclerosis and increased the risk of ischemic stroke. 30778327

2019

Entrez Id: 217
Gene Symbol: ALDH2
ALDH2
CUI: C0948008
Disease: Ischemic stroke
Ischemic stroke
0.150 GeneticVariation BEFREE <b>Conclusion:</b> Our meta-analysis indicates that the <i>ALDH2</i> rs671 G>A polymorphism may play an important role in the occurrence of IS by reducing the activity of ALDH2 and interfering with the metabolic processes involving acetaldehyde. 31114208

2019

Entrez Id: 1401
Gene Symbol: CRP
CRP
CUI: C0948008
Disease: Ischemic stroke
Ischemic stroke
0.100 GeneticVariation BEFREE <b>Results</b>: Three out of 10 eligible SNPs were shown to be associated with risk of ischemic stroke. rs1800947 in <i>CRP</i> gene (additive model: OR = 2.08, 95% CI: 1.00-4.23) and rs1169288 in <i>HNF1A</i> gene (additive model: OR = 1.45, 95% CI: 1.03-2.06) were associated with an increased risk of ischemic stroke. rs440446 in <i>APOE</i> gene (additive model: OR = 0.63, 95%CI: 0.44-0.88) was associated with a decreased risk of ischemic stroke. 31584351

2019

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0948008
Disease: Ischemic stroke
Ischemic stroke
0.020 Biomarker BEFREE <b>Results:</b> The median mRNA levels of TIPE2, TNF-α, AP-1, IFN-γ and NF-κβ in patients with acute ischemic stroke were significantly higher than healthy controls (all <i>P</i><0.001, respectively). 30588195

2018

Entrez Id: 3586
Gene Symbol: IL10
IL10
CUI: C0948008
Disease: Ischemic stroke
Ischemic stroke
0.100 Biomarker BEFREE <i>In vitro</i> and <i>in vivo</i> models of ischemic stroke have convincingly directly and indirectly shown IL-10-mediated neuroprotection; although clinically, the role of IL-10 in predicting risk and outcomes is less clear. 28659854

2017

Entrez Id: 6625
Gene Symbol: SNRNP70
SNRNP70
CUI: C0948008
Disease: Ischemic stroke
Ischemic stroke
0.010 GeneticVariation BEFREE <i>TIMD4</i> rs6882076 SNP Is Associated with Decreased Levels of Triglycerides and the Risk of Coronary Heart Disease and Ischemic Stroke. 31337960

2019

Entrez Id: 706
Gene Symbol: TSPO
TSPO
CUI: C0948008
Disease: Ischemic stroke
Ischemic stroke
0.020 Biomarker BEFREE <sup>11</sup>C-DPA-713 Versus <sup>18</sup>F-GE-180: A Preclinical Comparison of Translocator Protein 18 kDa PET Tracers to Visualize Acute and Chronic Neuroinflammation in a Mouse Model of Ischemic Stroke. 29976695

2019

Entrez Id: 255738
Gene Symbol: PCSK9
PCSK9
CUI: C0948008
Disease: Ischemic stroke
Ischemic stroke
0.100 Biomarker BEFREE 324 patients with acute ischemic stroke and TIA were further screened for PCSK9-inhibitor treatment eligibility. 31732461

2020

Entrez Id: 5054
Gene Symbol: SERPINE1
SERPINE1
CUI: C0948008
Disease: Ischemic stroke
Ischemic stroke
0.100 GeneticVariation BEFREE 4G/5G promoter polymorphism of plasminogen activator inhibitor-1, lipid profiles, and ischemic stroke. 12960956

2003

Entrez Id: 51206
Gene Symbol: GP6
GP6
CUI: C0948008
Disease: Ischemic stroke
Ischemic stroke
0.050 GeneticVariation BEFREE Ischaemic strokes and homozygosity for the alpha2 807T allele of the platelet collagen receptor in young monozygotic twins. 12544734

2003

Entrez Id: 948
Gene Symbol: CD36
CD36
CUI: C0948008
Disease: Ischemic stroke
Ischemic stroke
0.010 GeneticVariation BEFREE Ischaemic strokes and homozygosity for the alpha2 807T allele of the platelet collagen receptor in young monozygotic twins. 12544734

2003

Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
CUI: C0948008
Disease: Ischemic stroke
Ischemic stroke
0.100 GeneticVariation BEFREE Ischemic stroke in a 7-month-old infant with antiphospholipid antibody and homozygous C677T methylenetetrahydrofolate reductase (MTHFR) polymorphism. 20110213

2010

Entrez Id: 28
Gene Symbol: ABO
ABO
CUI: C0948008
Disease: Ischemic stroke
Ischemic stroke
0.150 GeneticVariation BEFREE Ischemic stroke is associated with the ABO locus: the EuroCLOT study. 23381943

2013

Entrez Id: 240
Gene Symbol: ALOX5
ALOX5
CUI: C0948008
Disease: Ischemic stroke
Ischemic stroke
0.100 GeneticVariation BEFREE Ischemic stroke risk in a southeastern Chinese population: Insights from 5-lipoxygenase activating protein and phosphodiesterase 4D single-nucleotide polymorphisms. 24485247

2015

Entrez Id: 1401
Gene Symbol: CRP
CRP
CUI: C0948008
Disease: Ischemic stroke
Ischemic stroke
0.100 GeneticVariation BEFREE Ischemic Stroke and Six Genetic Variants in CRP, EPHX2, FGA, and NOTCH3 Genes: A Meta-Analysis. 27266621

2016

Entrez Id: 9360
Gene Symbol: PPIG
PPIG
CUI: C0948008
Disease: Ischemic stroke
Ischemic stroke
0.060 GeneticVariation BEFREE Ischemic stroke (IS) is the main cause of mortality and disability among the old people in China and is a multifactorial disease influenced by many factors including genetic factors like the allele for CYP 2J2. 28272236

2017

Entrez Id: 100128998
Gene Symbol: C20orf181
C20orf181
CUI: C0948008
Disease: Ischemic stroke
Ischemic stroke
0.100 Biomarker BEFREE Ischaemic stroke and the recanalization drug tissue plasminogen activator interfere with antibacterial phagocyte function. 28732504

2017

Entrez Id: 6363
Gene Symbol: CCL19
CCL19
CUI: C0948008
Disease: Ischemic stroke
Ischemic stroke
0.010 AlteredExpression BEFREE Ischemic stroke damages the intestinal mucosa and induces alteration of the intestinal lymphocytes and CCL19 mRNA in rats. 28859865

2017

Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0948008
Disease: Ischemic stroke
Ischemic stroke
0.100 Biomarker BEFREE Ischemic stroke induced matrixmetallo-proteinase-9 (MMP-9) upregulation, which increased blood-brain barrier permeability. 29724240

2018

Entrez Id: 7099
Gene Symbol: TLR4
TLR4
CUI: C0948008
Disease: Ischemic stroke
Ischemic stroke
0.100 AlteredExpression BEFREE Ischemic stroke increased the expression of TLR-4 in both hemispheres and in the microvasculature of diabetic animals. 29909454

2019

Entrez Id: 340348
Gene Symbol: TSPAN33
TSPAN33
CUI: C0948008
Disease: Ischemic stroke
Ischemic stroke
0.100 AlteredExpression BEFREE Ischemic stroke decreased Trx-1 activity but not the expression in penumbra tissue. 30447684

2018