Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 8241
Gene Symbol: RBM10
RBM10
CUI: C0007103
Disease: Malignant neoplasm of endometrium
Malignant neoplasm of endometrium
0.010 AlteredExpression BEFREE VEGFA alternative splicing in endometrial cancer was regulated by RBM10, the expression of which was controlled by histone acetylation and DNA methylation. 31587503

2020

Entrez Id: 4192
Gene Symbol: MDK
MDK
CUI: C0007103
Disease: Malignant neoplasm of endometrium
Malignant neoplasm of endometrium
0.010 Biomarker BEFREE We also discuss the possible relationship between metformin and MK in the context of EC, the most common gynecological cancer worldwide, which incidence is rising rapidly, in parallel with the increase in obesity, T2DM and insulin resistance. 31634770

2020

Entrez Id: 101927193
Gene Symbol: CHL1-AS1
CHL1-AS1
CUI: C0007103
Disease: Malignant neoplasm of endometrium
Malignant neoplasm of endometrium
0.010 Biomarker BEFREE Knockdown of CHL1-AS1 or CHL1 inhibited cell proliferation and migration in EC. 31736153

2020

Entrez Id: 11065
Gene Symbol: UBE2C
UBE2C
CUI: C0007103
Disease: Malignant neoplasm of endometrium
Malignant neoplasm of endometrium
0.010 Biomarker BEFREE UBE2C knockdown inhibited EC cell proliferation, migration, invasion, and epithelial-mesenchymal transition (EMT), whereas UBE2C overexpression exerted the opposite effects. 31662448

2020

Entrez Id: 407018
Gene Symbol: MIR27A
MIR27A
CUI: C0007103
Disease: Malignant neoplasm of endometrium
Malignant neoplasm of endometrium
0.010 Biomarker BEFREE The role of miR-27a-5p in EC migration and invasion was further investigated via transfection with miR-27a-5p mimics or inhibitor in Ishikawa and HEC-1A EC cell lines. 31710594

2020

Entrez Id: 51155
Gene Symbol: JPT1
JPT1
CUI: C0007103
Disease: Malignant neoplasm of endometrium
Malignant neoplasm of endometrium
0.010 Biomarker BEFREE We further identified that silencing of JPT1 abundance does not alter cellular response to metformin or basal cell proliferation, but that JPT1 abundance does decrease in response to metformin treatment in RL95-2 and ACI-181 EC cell lines. 31808620

2020

Entrez Id: 10752
Gene Symbol: CHL1
CHL1
CUI: C0007103
Disease: Malignant neoplasm of endometrium
Malignant neoplasm of endometrium
0.010 Biomarker BEFREE Knockdown of CHL1-AS1 or CHL1 inhibited cell proliferation and migration in EC. 31736153

2020

Entrez Id: 7919
Gene Symbol: DDX39B
DDX39B
CUI: C0007103
Disease: Malignant neoplasm of endometrium
Malignant neoplasm of endometrium
0.010 Biomarker BEFREE We think that it would be useful to determine the diagnosis, prediction of prognosis and identifying therapeutic targets of the highlighted proteins of our study that are K2C8, UAP56, GRP78 and CALR in endometrial cancer. 31783195

2020

Entrez Id: 57556
Gene Symbol: SEMA6A
SEMA6A
CUI: C0007103
Disease: Malignant neoplasm of endometrium
Malignant neoplasm of endometrium
0.010 Biomarker BEFREE All in all, our research was the first endeavor to study the underlying mechanism of CHL1-AS1 in EC and confirmed that CHL1-AS1 regulated EC progression via targeting the miR-6076/CHL1 axis, offering new insight into treating EC. 31736153

2020

Entrez Id: 1493
Gene Symbol: CTLA4
CTLA4
CUI: C0007103
Disease: Malignant neoplasm of endometrium
Malignant neoplasm of endometrium
0.010 Biomarker BEFREE Deep and Durable Response With Combination CTLA-4 and PD-1 Blockade in Mismatch Repair (MMR)-proficient Endometrial Cancer. 30247204

2020

Entrez Id: 55799
Gene Symbol: CACNA2D3
CACNA2D3
CUI: C0007103
Disease: Malignant neoplasm of endometrium
Malignant neoplasm of endometrium
0.010 Biomarker BEFREE These data revealed that CACNA2D3 functions as a tumor suppressor in EC. 31746409

2020

Entrez Id: 3956
Gene Symbol: LGALS1
LGALS1
CUI: C0007103
Disease: Malignant neoplasm of endometrium
Malignant neoplasm of endometrium
0.010 AlteredExpression BEFREE The positive rate of Galectin-1 expression in NE, AH, and endometrial cancer was 30, 70, and 90.2%. 31487707

2020

Entrez Id: 9037
Gene Symbol: SEMA5A
SEMA5A
CUI: C0007103
Disease: Malignant neoplasm of endometrium
Malignant neoplasm of endometrium
0.010 AlteredExpression BEFREE The aim of the study was to determine the changes in SEMA5A expression in endometrial cancer compared to normal endometrium and to indicate the potential use of SEMA5A as a molecular marker. 31544715

2020

Entrez Id: 64115
Gene Symbol: VSIR
VSIR
CUI: C0007103
Disease: Malignant neoplasm of endometrium
Malignant neoplasm of endometrium
0.010 AlteredExpression BEFREE Upregulation of VISTA in endometrial cancer was related to the methylation status of the VISTA promoter. 30382166

2019

Entrez Id: 6694
Gene Symbol: SPP2
SPP2
CUI: C0007103
Disease: Malignant neoplasm of endometrium
Malignant neoplasm of endometrium
0.010 GeneticVariation BEFREE In addition, SPP1 and SPP2 mutations mainly occurred in cutaneous melanoma and endometrial cancer. 31849319

2019

Entrez Id: 10418
Gene Symbol: SPON1
SPON1
CUI: C0007103
Disease: Malignant neoplasm of endometrium
Malignant neoplasm of endometrium
0.010 Biomarker BEFREE F-Spondin Is the Signal by Which 2-Methoxyestradiol Induces Apoptosis in the Endometrial Cancer Cell Line Ishikawa. 31394756

2019

Entrez Id: 284348
Gene Symbol: LYPD5
LYPD5
CUI: C0007103
Disease: Malignant neoplasm of endometrium
Malignant neoplasm of endometrium
0.010 Biomarker BEFREE Though metastasis-associated protein 1 (MTA1) is widely overexpressed in human cancers and is associated with advanced clinicopathological characteristics and survival in related diseases, the association between MTA1 and endometrial cancer (EC) is little known and needs to be studied. 30979588

2019

Entrez Id: 9709
Gene Symbol: HERPUD1
HERPUD1
CUI: C0007103
Disease: Malignant neoplasm of endometrium
Malignant neoplasm of endometrium
0.010 Biomarker BEFREE Co-expression analysis showed lnc-CETP-3 was highly correlated with CHOP and HERPUD1, suggesting it might participate in ER stress pathway-related EC cell apoptosis caused by MPA. 31718641

2019

Entrez Id: 119
Gene Symbol: ADD2
ADD2
CUI: C0007103
Disease: Malignant neoplasm of endometrium
Malignant neoplasm of endometrium
0.010 Biomarker BEFREE In the present study, we elucidated that miR-218 served as a tumor suppressor in EC by negatively regulating ADD2. 30840261

2019

Entrez Id: 22839
Gene Symbol: DLGAP4
DLGAP4
CUI: C0007103
Disease: Malignant neoplasm of endometrium
Malignant neoplasm of endometrium
0.010 GeneticVariation BEFREE Seven genes, including <i>RBM12, NDUFB6, ATP6V1A, RECK, SLC35E1, RFX3</i> (<i>Bonferroni-corrected P</i> < 0.05) and <i>ATP8A1</i> (suggestive <i>P</i> < 10<sup>-5</sup>), and one long non-coding RNA, <i>DLGAP4-AS1</i> (<i>Bonferroni-corrected P</i> < 0.05), were associated with endometrial cancer. 31338326

2019

Entrez Id: 1036
Gene Symbol: CDO1
CDO1
CUI: C0007103
Disease: Malignant neoplasm of endometrium
Malignant neoplasm of endometrium
0.010 PosttranslationalModification BEFREE Adding PTEN/TP53 mutation testing to BHLHE22/CDO1-based methylation testing did not improve the detection of endometrial cancer. 31779688

2019

Entrez Id: 1748
Gene Symbol: DLX4
DLX4
CUI: C0007103
Disease: Malignant neoplasm of endometrium
Malignant neoplasm of endometrium
0.010 AlteredExpression BEFREE We found that expression of DLX7, a splicing isoform of DLX4, did not show any significant difference in expression between endometrial cancer and endometrium. 31100338

2019

Entrez Id: 5553
Gene Symbol: PRG2
PRG2
CUI: C0007103
Disease: Malignant neoplasm of endometrium
Malignant neoplasm of endometrium
0.010 Biomarker BEFREE X chromosome-linked long noncoding RNA lnc-XLEC1 regulates c-Myc-dependent cell growth by collaborating with MBP-1 in endometrial cancer. 30698832

2019

Entrez Id: 79633
Gene Symbol: FAT4
FAT4
CUI: C0007103
Disease: Malignant neoplasm of endometrium
Malignant neoplasm of endometrium
0.010 AlteredExpression BEFREE The association of decreased FAT4 expression with advanced signature (lymph node metastasis, lymphovascular invasion and muscular infiltration) in EC patients was also confirmed by our own dataset. 31217854

2019

Entrez Id: 57101
Gene Symbol: ANO2
ANO2
CUI: C0007103
Disease: Malignant neoplasm of endometrium
Malignant neoplasm of endometrium
0.010 Biomarker BEFREE Additionally, there are active regulatory effects in dysfunction modules, thus genes such as ANO2 and EMP3 would be identified as key genes, which are associated with the development of EC. 31140648

2019