Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4221
Gene Symbol: MEN1
MEN1
CUI: C0025267
Disease: Multiple Endocrine Neoplasia Type 1
Multiple Endocrine Neoplasia Type 1
0.900 GeneticVariation BEFREE Both mouse models developed well-differentiated (WD) G1/G2 PanNETs at a much shorter latency than Men1 or Pten single deletion alone and exhibited histopathology of human MEN1-like tumor. 31160716

2020

Entrez Id: 4221
Gene Symbol: MEN1
MEN1
CUI: C0025267
Disease: Multiple Endocrine Neoplasia Type 1
Multiple Endocrine Neoplasia Type 1
0.900 GeneticVariation BEFREE Fourteen patients with a clinical diagnosis (n=13) or suspicion (n=1) of MEN1 who had negative genetic screening of the MEN1 gene were included. 31658439

2020

Entrez Id: 4221
Gene Symbol: MEN1
MEN1
CUI: C0025267
Disease: Multiple Endocrine Neoplasia Type 1
Multiple Endocrine Neoplasia Type 1
0.900 Biomarker BEFREE MEN1 is caused by inactivating mutations of the tumor suppressor gene <i>MEN1</i> which encodes the protein menin. 31263451

2019

Entrez Id: 4221
Gene Symbol: MEN1
MEN1
CUI: C0025267
Disease: Multiple Endocrine Neoplasia Type 1
Multiple Endocrine Neoplasia Type 1
0.900 GeneticVariation BEFREE Genetic analysis of MEN1 and other ACC associated genes, loss of heterozygosity (LOH) of MEN1 locus, immunohistochemistry staining of menin, P53 and β-catenin in ACC tissue were performed. 30721134

2019

Entrez Id: 4221
Gene Symbol: MEN1
MEN1
CUI: C0025267
Disease: Multiple Endocrine Neoplasia Type 1
Multiple Endocrine Neoplasia Type 1
0.900 AlteredExpression BEFREE We reported that inactivation of menin (the protein product of MEN1) increases activity of Dnmt1 and mediates DNA hypermethylation in the development of multiple endocrine neoplasia type 1 (MEN1) syndrome. 30190513

2019

Entrez Id: 4221
Gene Symbol: MEN1
MEN1
CUI: C0025267
Disease: Multiple Endocrine Neoplasia Type 1
Multiple Endocrine Neoplasia Type 1
0.900 Biomarker BEFREE Menin, a protein encoded by the <i>MEN1</i> gene, suppresses cancers associated with multiple endocrine neoplasia type 1 (MEN1), but promotes the development of a subset of leukemia induced by mixed lineage leukemia (MLL)-derived fusion proteins (MLL-FPs). 31497350

2019

Entrez Id: 4221
Gene Symbol: MEN1
MEN1
CUI: C0025267
Disease: Multiple Endocrine Neoplasia Type 1
Multiple Endocrine Neoplasia Type 1
0.900 Biomarker BEFREE To date, a large number of frameshift, nonsense and missense mutations of MEN1 have been identified to be responsible for part of MEN1-defficient PNETs patients due to truncation or rapid degradation of menin protein. 31652443

2019

Entrez Id: 4221
Gene Symbol: MEN1
MEN1
CUI: C0025267
Disease: Multiple Endocrine Neoplasia Type 1
Multiple Endocrine Neoplasia Type 1
0.900 GeneticVariation BEFREE Multiple endocrine neoplasia type 1 (MEN1) is an autosomal dominant disease caused by mutations in the MEN1 gene characterized by a broad spectrum of clinical manifestations, of which the most frequent are primary hyperparathyroidism, pituitary adenomas, and neuroendocrine tumors. 30339208

2019

Entrez Id: 4221
Gene Symbol: MEN1
MEN1
CUI: C0025267
Disease: Multiple Endocrine Neoplasia Type 1
Multiple Endocrine Neoplasia Type 1
0.900 GeneticVariation BEFREE Based on the array data, we concluded that the deletion was limited to the MEN1 gene and that the father had both germline and somatic mosaicism for MEN1. 30481156

2019

Entrez Id: 4221
Gene Symbol: MEN1
MEN1
CUI: C0025267
Disease: Multiple Endocrine Neoplasia Type 1
Multiple Endocrine Neoplasia Type 1
0.900 GeneticVariation BEFREE Pituitary adenomas (PAs) may rarely occur in well-defined hereditary conditions, like multiple endocrine neoplasia type 1 (MEN1) syndrome and familial isolated pituitary adenoma (FIPA) associated with germline mutations in MEN1 and AIP, respectively. 30630164

2019

Entrez Id: 4221
Gene Symbol: MEN1
MEN1
CUI: C0025267
Disease: Multiple Endocrine Neoplasia Type 1
Multiple Endocrine Neoplasia Type 1
0.900 Biomarker BEFREE True MEN1 or phenocopy? Evidence for geno-phenotypic correlations in MEN1 syndrome. 31044390

2019

Entrez Id: 4221
Gene Symbol: MEN1
MEN1
CUI: C0025267
Disease: Multiple Endocrine Neoplasia Type 1
Multiple Endocrine Neoplasia Type 1
0.900 Biomarker BEFREE Menin is the protein mutated in patients with multiple endocrine neoplasia type 1 (MEN1) syndrome and their corresponding sporadic tumor counterparts. 31211356

2019

Entrez Id: 4221
Gene Symbol: MEN1
MEN1
CUI: C0025267
Disease: Multiple Endocrine Neoplasia Type 1
Multiple Endocrine Neoplasia Type 1
0.900 Biomarker BEFREE All MEN 1 positive (MEN 1<sup>+</sup> , n = 63) and MEN 1 negative (MEN 1<sup>-</sup> , n = 75) descendants born between 1825 and 1951 of a common founder. 30368878

2019

Entrez Id: 4221
Gene Symbol: MEN1
MEN1
CUI: C0025267
Disease: Multiple Endocrine Neoplasia Type 1
Multiple Endocrine Neoplasia Type 1
0.900 GeneticVariation BEFREE Intraoperative liver exploration and lymphadenectomy should be routinely performed; (2) For multiple endocrine neoplasia type 1-related ZES (MEN1/ZES), surgery should not be performed routinely except for lesions > 2 cm. 31528093

2019

Entrez Id: 4221
Gene Symbol: MEN1
MEN1
CUI: C0025267
Disease: Multiple Endocrine Neoplasia Type 1
Multiple Endocrine Neoplasia Type 1
0.900 GeneticVariation BEFREE Whole-exome sequencing performed in a Clinical Laboratory Improvement Amendments-approved genetic diagnostic laboratory uncovered a de novo heterozygous pathogenic variant in novel candidate PNH gene MEN1 (multiple endocrine neoplasia type 1; c.1546dupC, p.R516PfsX15). 31489630

2019

Entrez Id: 4221
Gene Symbol: MEN1
MEN1
CUI: C0025267
Disease: Multiple Endocrine Neoplasia Type 1
Multiple Endocrine Neoplasia Type 1
0.900 Biomarker BEFREE Causes of death were classified as related to GDP surgery, related to surgery for other MEN1 lesions or not related to MEN1 causes. 31384998

2019

Entrez Id: 4221
Gene Symbol: MEN1
MEN1
CUI: C0025267
Disease: Multiple Endocrine Neoplasia Type 1
Multiple Endocrine Neoplasia Type 1
0.900 Biomarker BEFREE We aim to analyze MEN1 mutation site and features, and possible correlations between the mutation type and/or the affected menin functional domain and clinical presentation in patients from the Italian multicenter MEN1 database, one of the largest worldwide MEN1 mutation series published to date. 29497973

2018

Entrez Id: 4221
Gene Symbol: MEN1
MEN1
CUI: C0025267
Disease: Multiple Endocrine Neoplasia Type 1
Multiple Endocrine Neoplasia Type 1
0.900 GeneticVariation BEFREE Ten subjects (45.5%) have not yet presented any clinical/biochemical/radiological manifestation of MEN1 disease, whereas 12 patients (54.5%) developed at least one MEN1-associated endocrine manifestation. 28530019

2018

Entrez Id: 4221
Gene Symbol: MEN1
MEN1
CUI: C0025267
Disease: Multiple Endocrine Neoplasia Type 1
Multiple Endocrine Neoplasia Type 1
0.900 Biomarker BEFREE Pathway analysis demonstrated subtype-specific pathway activation, comprising angiogenesis and immune response in VHL; neuronal development in MEN1; protein ubiquitination in the new MEN1/sporadic subtype; and cytokinesis and cilium/microtubule development in sporadic NFPanNETs. 29149451

2018

Entrez Id: 4221
Gene Symbol: MEN1
MEN1
CUI: C0025267
Disease: Multiple Endocrine Neoplasia Type 1
Multiple Endocrine Neoplasia Type 1
0.900 GeneticVariation BEFREE Correction to: Multiple endocrine neoplasia type 1: analysis of germline MEN1 mutations in the Italian multicenter MEN1 patient database. 30032405

2018

Entrez Id: 4221
Gene Symbol: MEN1
MEN1
CUI: C0025267
Disease: Multiple Endocrine Neoplasia Type 1
Multiple Endocrine Neoplasia Type 1
0.900 GeneticVariation BEFREE Sanger-directed sequencing on a peripheral blood sample revealed an MEN1 gene mutation, indicating pediatric insulinoma with MEN1 syndrome. 29921249

2018

Entrez Id: 4221
Gene Symbol: MEN1
MEN1
CUI: C0025267
Disease: Multiple Endocrine Neoplasia Type 1
Multiple Endocrine Neoplasia Type 1
0.900 Biomarker BEFREE Our work indicates that Men1-a tumor suppressor gene responsible of Multiple endocrine neoplasia type 1-is critical for OF formation and shows that mice with targeted disruption of Men1 in osteoblasts (Men1<sup>Runx2Cre</sup>) develop multifocal OF in the mandible with a 100% penetrance. 28991228

2018

Entrez Id: 4221
Gene Symbol: MEN1
MEN1
CUI: C0025267
Disease: Multiple Endocrine Neoplasia Type 1
Multiple Endocrine Neoplasia Type 1
0.900 AlteredExpression BEFREE MicroRNAs (miRNA) are non-coding single stranded RNAs that post-transcriptionally regulate gene expression and have been associated with tumour development, although the contribution of miRNAs to MEN1-associated tumourigenesis and their relationship with menin expression are not fully understood. 30389902

2018

Entrez Id: 4221
Gene Symbol: MEN1
MEN1
CUI: C0025267
Disease: Multiple Endocrine Neoplasia Type 1
Multiple Endocrine Neoplasia Type 1
0.900 GeneticVariation BEFREE As such, MEN1 mutations are associated with multiple endocrine neoplasia type 1 (MEN1) syndrome. 30021166

2018

Entrez Id: 4221
Gene Symbol: MEN1
MEN1
CUI: C0025267
Disease: Multiple Endocrine Neoplasia Type 1
Multiple Endocrine Neoplasia Type 1
0.900 GeneticVariation BEFREE Most cases are sporadic but can rarely occur in the context of familial predisposition, due to germline mutations in genes such as MEN1, leading to multiple endocrine neoplasia type 1, MEN1. 29927501

2018