Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 6421
Gene Symbol: SFPQ
SFPQ
CUI: C0007789
Disease: Cerebral Palsy
Cerebral Palsy
0.010 AlteredExpression BEFREE A total of 157 patients with nonambulatory CP (Gross Motor Function Classification System IV and V) with a minimum of 2-year follow-up after PSF were identified from a prospective multicenter registry. 31306277

2020

Entrez Id: 3490
Gene Symbol: IGFBP7
IGFBP7
CUI: C0007789
Disease: Cerebral Palsy
Cerebral Palsy
0.010 AlteredExpression BEFREE A total of 157 patients with nonambulatory CP (Gross Motor Function Classification System IV and V) with a minimum of 2-year follow-up after PSF were identified from a prospective multicenter registry. 31306277

2020

Entrez Id: 51107
Gene Symbol: APH1A
APH1A
CUI: C0007789
Disease: Cerebral Palsy
Cerebral Palsy
0.010 AlteredExpression BEFREE A total of 157 patients with nonambulatory CP (Gross Motor Function Classification System IV and V) with a minimum of 2-year follow-up after PSF were identified from a prospective multicenter registry. 31306277

2020

Entrez Id: 3558
Gene Symbol: IL2
IL2
CUI: C0007789
Disease: Cerebral Palsy
Cerebral Palsy
0.010 AlteredExpression BEFREE In addition, in CP-treated rats, PGE treatment induced the recovery of white blood cell, neutrophil, and lymphocyte counts, along with mid-range absolute counts, and increased the serum levels of inflammatory cytokines (TNF-α, IFN-γ, IL-2, and IL-12) and immunoglobulins (IgG and IgA). 31752816

2019

Entrez Id: 219844
Gene Symbol: HYLS1
HYLS1
CUI: C0007789
Disease: Cerebral Palsy
Cerebral Palsy
0.010 Biomarker BEFREE This retrospective cohort study included 87 ambulatory children with CP who underwent HLS surgery with both preoperative and postoperative gait analysis (mean time, 29.4±19.9 mo after surgery) testing between 1997 and 2015. 31305380

2019

Entrez Id: 339345
Gene Symbol: NANOS2
NANOS2
CUI: C0007789
Disease: Cerebral Palsy
Cerebral Palsy
0.010 GeneticVariation BEFREE We investigated whether the risk for cerebral palsy (CP) increases when an expansion of the - 2.5 kb (CCTTT)n microsatellite in the NOS2A gene and a single nucleotide polymorphism (SNP) in -C511T of the IL- IL-1β gene promoter occur in patients after perinatal hypoxic-ischemic encephalopathy. 29931509

2019

Entrez Id: 3251
Gene Symbol: HPRT1
HPRT1
CUI: C0007789
Disease: Cerebral Palsy
Cerebral Palsy
0.010 AlteredExpression BEFREE In 23 patients molecular diagnosis was reached and included 5 hereditary spastic paraplegia genes (SPG) in spastic CP mimics; HPRT1, TH, QDPR, DDC in dystonic CP mimics; ADCY5 and NIKX2-1 in choreic CP mimics; CANA1A in ataxic CP mimics; and SPG, PDHA1, NIKX2-1, AT, SLC2A1 and SPR in mixed CP mimics. 30799092

2019

Entrez Id: 7273
Gene Symbol: TTN
TTN
CUI: C0007789
Disease: Cerebral Palsy
Cerebral Palsy
0.010 Biomarker BEFREE Titin isoforms were not different between CP and non-CP adductor longus but titin:nebulin was reduced in CP muscle, which may be due to titin loss or an over-expression of nebulin in CP muscles. 30853092

2019

Entrez Id: 373156
Gene Symbol: GSTK1
GSTK1
CUI: C0007789
Disease: Cerebral Palsy
Cerebral Palsy
0.010 AlteredExpression BEFREE On the other hand, tissue antioxidant levels (GSH, GST, and catalase) showed a significant increase in LA-Q-ORMOSIL treated group compared to the CP treated group confirming its high therapeutic efficacy during liver injury. 31819411

2019

Entrez Id: 5555
Gene Symbol: PRH2
PRH2
CUI: C0007789
Disease: Cerebral Palsy
Cerebral Palsy
0.010 Biomarker BEFREE In conclusion, NaB ameliorated CP infection in RAW264.7 macrophages and C57BL/6 mice, and these effects may be related to the modulation of sodC, spaC, pld, and cramp expression. 30965088

2019

Entrez Id: 6414
Gene Symbol: SELENOP
SELENOP
CUI: C0007789
Disease: Cerebral Palsy
Cerebral Palsy
0.010 Biomarker BEFREE Absent SEP combined with continuous EEG background in near-term neonates indicates an MCA stroke and a high risk for cerebral palsy. 30904770

2019

Entrez Id: 4843
Gene Symbol: NOS2
NOS2
CUI: C0007789
Disease: Cerebral Palsy
Cerebral Palsy
0.010 GeneticVariation BEFREE The 14 repeat-long allele of the CCTTTn NOS2A microsatellite was present in 27% of CP patients vs 12.3% of controls, showing an odds ratio (OR) = 2.6531 and 95% confidence interval (CI) = 0.9612-7.3232 (P < 0.0469). 29931509

2019

Entrez Id: 9048
Gene Symbol: ARTN
ARTN
CUI: C0007789
Disease: Cerebral Palsy
Cerebral Palsy
0.010 Biomarker BEFREE The data that are available for malignancies seem reassuring, while results on neurodevelopmental health are more equivocal with a possible association between ART and cerebral palsy. 30753453

2019

Entrez Id: 7852
Gene Symbol: CXCR4
CXCR4
CUI: C0007789
Disease: Cerebral Palsy
Cerebral Palsy
0.010 Biomarker BEFREE The first aim of this study was to investigate the <i>CXCR2</i> gene variability in chronic periodontitis (CP) patients and healthy nonperiodontitis controls in the Czech population. 30863202

2019

Entrez Id: 2268
Gene Symbol: FGR
FGR
CUI: C0007789
Disease: Cerebral Palsy
Cerebral Palsy
0.010 Biomarker BEFREE FGR/IUGR, prematurity and zygosity affect neurodevelopmental outcome; CP is higher in term infants, those presenting with FGR/IUGR, as well as in survivors of intrauterine co-twin death; cognitive ability of twins versus singletons mainly relates to confounding factors, as FGR/IUGR and prematurity, while evidence for differences in behavioral and psychiatric disorders between twins and singletons is limited. 29307249

2019

Entrez Id: 111
Gene Symbol: ADCY5
ADCY5
CUI: C0007789
Disease: Cerebral Palsy
Cerebral Palsy
0.010 Biomarker BEFREE In 23 patients molecular diagnosis was reached and included 5 hereditary spastic paraplegia genes (SPG) in spastic CP mimics; HPRT1, TH, QDPR, DDC in dystonic CP mimics; ADCY5 and NIKX2-1 in choreic CP mimics; CANA1A in ataxic CP mimics; and SPG, PDHA1, NIKX2-1, AT, SLC2A1 and SPR in mixed CP mimics. 30799092

2019

Entrez Id: 55054
Gene Symbol: ATG16L1
ATG16L1
CUI: C0007789
Disease: Cerebral Palsy
Cerebral Palsy
0.010 Biomarker BEFREE However, <i>in vivo</i>, mice with myeloid-specific deletion of the autophagic protein ATG16L1 suffered increased mortality during CP infection, neutrophilia, and increased inflammasome activation despite no change in bacterial burden. 31031755

2019

Entrez Id: 56476
Gene Symbol: ABCB10P1
ABCB10P1
CUI: C0007789
Disease: Cerebral Palsy
Cerebral Palsy
0.010 Biomarker BEFREE A third of cooled children without CP had MABC-2 scores indicating motor impairment at school age that was not identified at 18 months by Bayley-III. 30883895

2019

Entrez Id: 122402
Gene Symbol: TDRD9
TDRD9
CUI: C0007789
Disease: Cerebral Palsy
Cerebral Palsy
0.010 Biomarker BEFREE This retrospective cohort study included 87 ambulatory children with CP who underwent HLS surgery with both preoperative and postoperative gait analysis (mean time, 29.4±19.9 mo after surgery) testing between 1997 and 2015. 31305380

2019

Entrez Id: 8436
Gene Symbol: CAVIN2
CAVIN2
CUI: C0007789
Disease: Cerebral Palsy
Cerebral Palsy
0.010 AlteredExpression BEFREE Whether the newly modified rhizotomy protocol is applicable to guide single-level approach SDR to treat spastic quadriplegia and diplegia in pediatric patients with cerebral palsy? 31502037

2019

Entrez Id: 331
Gene Symbol: XIAP
XIAP
CUI: C0007789
Disease: Cerebral Palsy
Cerebral Palsy
0.010 AlteredExpression BEFREE Our study demonstrates that XIAP overexpressed BMSCs can inhibit the apoptosis of brain nerve cells and the activation of astrocytes, increase AchE activity, and inhibit Ach content, so as to lower the CP caused by cerebral ischemia and hypoxia in rats. 31660045

2019

Entrez Id: 5364
Gene Symbol: PLXNB1
PLXNB1
CUI: C0007789
Disease: Cerebral Palsy
Cerebral Palsy
0.010 Biomarker BEFREE Absent SEP combined with continuous EEG background in near-term neonates indicates an MCA stroke and a high risk for cerebral palsy. 30904770

2019

Entrez Id: 133482
Gene Symbol: SLCO6A1
SLCO6A1
CUI: C0007789
Disease: Cerebral Palsy
Cerebral Palsy
0.010 AlteredExpression BEFREE On the other hand, tissue antioxidant levels (GSH, GST, and catalase) showed a significant increase in LA-Q-ORMOSIL treated group compared to the CP treated group confirming its high therapeutic efficacy during liver injury. 31819411

2019

Entrez Id: 10215
Gene Symbol: OLIG2
OLIG2
CUI: C0007789
Disease: Cerebral Palsy
Cerebral Palsy
0.010 GeneticVariation BEFREE Our results indicate that in the Han Chinese population, the polymorphisms of OLIG2 were associated with CP, especially in patients who had suffered HIE injury. 30178266

2019

Entrez Id: 3952
Gene Symbol: LEP
LEP
CUI: C0007789
Disease: Cerebral Palsy
Cerebral Palsy
0.010 AlteredExpression BEFREE Leptin levels were higher in the ARMS, FEP and CP patients than in the HCs. 30660810

2019