Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7421
Gene Symbol: VDR
VDR
CUI: C0041327
Disease: Tuberculosis, Pulmonary
Tuberculosis, Pulmonary
0.100 GeneticVariation BEFREE Vitamin D receptor gene polymorphisms and sputum conversion time in pulmonary tuberculosis patients. 17449323

2007

Entrez Id: 7421
Gene Symbol: VDR
VDR
CUI: C0041327
Disease: Tuberculosis, Pulmonary
Tuberculosis, Pulmonary
0.100 GeneticVariation BEFREE Vitamin D receptor ApaI (rs7975232), BsmI (rs1544410), Fok1 (rs2228570), and TaqI (rs731236) gene polymorphisms and susceptibility to pulmonary tuberculosis in an Iranian population: A systematic review and meta-analysis. 31740220

2019

Entrez Id: 7421
Gene Symbol: VDR
VDR
CUI: C0041327
Disease: Tuberculosis, Pulmonary
Tuberculosis, Pulmonary
0.100 GeneticVariation BEFREE Associations of VDR polymorphisms with treatment outcome were analyzed among 78 patients undergoing treatment of pulmonary TB. 15295697

2004

Entrez Id: 7421
Gene Symbol: VDR
VDR
CUI: C0041327
Disease: Tuberculosis, Pulmonary
Tuberculosis, Pulmonary
0.100 GeneticVariation BEFREE Both vitamin D deficiency and genetic variants in the vitamin D receptor (VDR) have been reported to associate with delayed response to intensive-phase therapy for pulmonary tuberculosis. 26193879

2015

Entrez Id: 7421
Gene Symbol: VDR
VDR
CUI: C0041327
Disease: Tuberculosis, Pulmonary
Tuberculosis, Pulmonary
0.100 GeneticVariation BEFREE Genomic DNA from 95 patients with pulmonary tuberculosis (PTB) and 117 ethnically matched, healthy controls were typed for HLA-DRB1, DRB3, DRB4, DRB5, DQB1, and VDR polymorphisms FokI, BsmI, ApaI, and TaqI using polymerase chain reaction-sequence specific primers (PCR-SSP). 16916662

2006

Entrez Id: 7421
Gene Symbol: VDR
VDR
CUI: C0041327
Disease: Tuberculosis, Pulmonary
Tuberculosis, Pulmonary
0.100 GeneticVariation BEFREE Heterozygous (TG) and mutants (GG) forms of Apa1 VDR SNPs were significantly associated with TBM compared to controls [TG; p = 0.001, OR = 2.86 (1.58-5.17), GG; p = 0.002, OR = 5.11 (1.80-14.54)] and pulmonary tuberculosis. 27207494

2016

Entrez Id: 7421
Gene Symbol: VDR
VDR
CUI: C0041327
Disease: Tuberculosis, Pulmonary
Tuberculosis, Pulmonary
0.100 GeneticVariation BEFREE In conclusion, VDR <i>Bsm</i>I polymorphism is not a risk factor for PTB in overall population. 28533426

2017

Entrez Id: 7421
Gene Symbol: VDR
VDR
CUI: C0041327
Disease: Tuberculosis, Pulmonary
Tuberculosis, Pulmonary
0.100 GeneticVariation BEFREE In the present study, the influence of non-MHC genes such as mannose binding protein (MBP), vitamin D receptor (VDR) and interleukin-1 receptor antagonist (IL-1RA) gene polymorphisms on lymphocyte response to Mycobacterium tuberculosis culture filtrate antigen (10 micrograms/ml) was studied in 44 patients with active pulmonary TB and the family contacts (35) and in 32 normal healthy subjects. 11094853

2000

Entrez Id: 7421
Gene Symbol: VDR
VDR
CUI: C0041327
Disease: Tuberculosis, Pulmonary
Tuberculosis, Pulmonary
0.100 GeneticVariation BEFREE NRAMP1 and VDR gene polymorphisms in susceptibility to pulmonary tuberculosis among Andhra Pradesh population in India: a case-control study. 28583097

2017

Entrez Id: 7421
Gene Symbol: VDR
VDR
CUI: C0041327
Disease: Tuberculosis, Pulmonary
Tuberculosis, Pulmonary
0.100 GeneticVariation BEFREE Our findings demonstrated associations between VDR polymorphisms and PTB development. 27595605

2016

Entrez Id: 7421
Gene Symbol: VDR
VDR
CUI: C0041327
Disease: Tuberculosis, Pulmonary
Tuberculosis, Pulmonary
0.100 GeneticVariation LHGDN Our findings support previous data showing that VDR SNPs modulate the risk for TB in West Africans and suggest that variation within DC-SIGN and PTX3 also affect the disease outcome. 17611589

2007

Entrez Id: 7421
Gene Symbol: VDR
VDR
CUI: C0041327
Disease: Tuberculosis, Pulmonary
Tuberculosis, Pulmonary
0.100 GeneticVariation BEFREE Our findings support previous data showing that VDR SNPs modulate the risk for TB in West Africans and suggest that variation within DC-SIGN and PTX3 also affect the disease outcome. 17611589

2007

Entrez Id: 7421
Gene Symbol: VDR
VDR
CUI: C0041327
Disease: Tuberculosis, Pulmonary
Tuberculosis, Pulmonary
0.100 GeneticVariation LHGDN Polymorphisms in the VDR and NRAMP1 gene are statistically associated with susceptibility to PTB in the Chinese Han population. 15141734

2004

Entrez Id: 7421
Gene Symbol: VDR
VDR
CUI: C0041327
Disease: Tuberculosis, Pulmonary
Tuberculosis, Pulmonary
0.100 GeneticVariation BEFREE Polymorphisms in the VDR and NRAMP1 gene are statistically associated with susceptibility to PTB in the Chinese Han population. 15141734

2004

Entrez Id: 7421
Gene Symbol: VDR
VDR
CUI: C0041327
Disease: Tuberculosis, Pulmonary
Tuberculosis, Pulmonary
0.100 GeneticVariation BEFREE Recent studies have implicated variation in the vitamin D receptor (VDR) gene in susceptibility to several diseases, including osteoporosis and pulmonary tuberculosis. 9841838

1999

Entrez Id: 7421
Gene Symbol: VDR
VDR
CUI: C0041327
Disease: Tuberculosis, Pulmonary
Tuberculosis, Pulmonary
0.100 GeneticVariation BEFREE Regulatory role of vitamin D receptor gene variants of Bsm I, Apa I, Taq I, and Fok I polymorphisms on macrophage phagocytosis and lymphoproliferative response to mycobacterium tuberculosis antigen in pulmonary tuberculosis. 15359111

2004

Entrez Id: 7421
Gene Symbol: VDR
VDR
CUI: C0041327
Disease: Tuberculosis, Pulmonary
Tuberculosis, Pulmonary
0.100 AlteredExpression BEFREE Regulatory role of Cdx-2 and Taq I polymorphism of vitamin D receptor gene on chemokine expression in pulmonary tuberculosis. 27067904

2016

Entrez Id: 7421
Gene Symbol: VDR
VDR
CUI: C0041327
Disease: Tuberculosis, Pulmonary
Tuberculosis, Pulmonary
0.100 GeneticVariation BEFREE Regulatory role of promoter and 3' UTR variants of vitamin D receptor gene on cytokine response in pulmonary tuberculosis. 18231846

2008

Entrez Id: 7421
Gene Symbol: VDR
VDR
CUI: C0041327
Disease: Tuberculosis, Pulmonary
Tuberculosis, Pulmonary
0.100 AlteredExpression BEFREE Relative quantification of mRNA using real-time PCR revealed increased VDR mRNA expression in live M. tuberculosis-stimulated culture in PTB patients (p < 0.01) than normal healthy subjects. 19219539

2009

Entrez Id: 7421
Gene Symbol: VDR
VDR
CUI: C0041327
Disease: Tuberculosis, Pulmonary
Tuberculosis, Pulmonary
0.100 Biomarker BEFREE Since human genetic variation is an important determinant in the outcome of infection with M. tuberculosis, we typed polymorphisms in the innate immune molecules, such as natural-resistance-associated macrophage protein 1 (NRAMP1), Vitamin D receptor (VDR), Tumor necrosis factor alpha (TNF-α), intercellular adhesion molecule1 (ICAM-1), Toll-like receptor 2 (TLR2) and Toll-like receptor 4 (TLR4) in a case-control study of pulmonary tuberculosis in Iranian population. 26774366

2016

Entrez Id: 7421
Gene Symbol: VDR
VDR
CUI: C0041327
Disease: Tuberculosis, Pulmonary
Tuberculosis, Pulmonary
0.100 GeneticVariation BEFREE The Vitamin D receptor (VDR) gene is a good candidate, because it influences immune response, and associations between TaqI and FokI polymorphisms in the VDR gene and pulmonary TB risk have been found. 16229232

2005

Entrez Id: 7421
Gene Symbol: VDR
VDR
CUI: C0041327
Disease: Tuberculosis, Pulmonary
Tuberculosis, Pulmonary
0.100 GeneticVariation BEFREE The heterozygous and mutant variants of VDR ApaI gene were significantly more common in patients with spinal tuberculosis in comparison with patients with pulmonary tuberculosis (P < 0.001; OR 2.90 [1.65-5.10]) and controls (P < 0.001; OR 6.56 [3.41-12.61]). 27124026

2016

Entrez Id: 7421
Gene Symbol: VDR
VDR
CUI: C0041327
Disease: Tuberculosis, Pulmonary
Tuberculosis, Pulmonary
0.100 GeneticVariation BEFREE The influence of FokI, BsmI, ApaI and TaqI variants of VDR gene on 1, 25(OH)(2) D(3) modulated granzyme A expression of cytotoxic lymphocytes induced by culture filtrate antigen (CFA) of Mycobacterium tuberculosis was studied in 40 pulmonary tuberculosis (PTB) patients and 49 normal healthy subjects (NHS) by flow cytometry. 19014932

2009

Entrez Id: 7421
Gene Symbol: VDR
VDR
CUI: C0041327
Disease: Tuberculosis, Pulmonary
Tuberculosis, Pulmonary
0.100 GeneticVariation BEFREE The present study suggested that the genotype tt of vitamin D receptor gene may be associated with susceptibility to pulmonary TB in female patients, and the genotype TT may be associated with resistance in female contacts. 10943070

2000

Entrez Id: 7421
Gene Symbol: VDR
VDR
CUI: C0041327
Disease: Tuberculosis, Pulmonary
Tuberculosis, Pulmonary
0.100 GeneticVariation BEFREE This meta-analysis suggested that the VDR FokI polymorphism is associated with a susceptibility to PTB in East Asians. 26345844

2015