×
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
Primary malignant neoplasm
0.100
GeneticVariation
BEFREE
791 cancer -specific mutations were detected in plasma of 88% patients with KRAS hotspots detected in 70% of all patients.
30857943 2019
×
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
Primary malignant neoplasm
0.100
GeneticVariation
BEFREE
Cancer gene mutations were identified in 46% of the 52 patient cohort and include TP53 (23%), PIK3CA (19%), KRAS (15%), CTNNB1 (4%) and NRAS (2%).21168197 2011
×
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
Primary malignant neoplasm
0.100
GeneticVariation
BEFREE
K-ras-2 was mutated in both cancer (87%) and pancreatitis (40%).11677475 2001
×
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
Primary malignant neoplasm
0.100
GeneticVariation
BEFREE
K-ras gene mutation was found more frequently in older patients and patients with polypoid cancer .11819789 2001
×
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
Primary malignant neoplasm
0.100
GeneticVariation
BEFREE
KRAS2 or TP53 mutations were detected in 13 of 1,098 (1.2%) and 20 of 550 (3.6%) subjects, respectively, 16 of whom developed cancer on average after 18.3 months of follow-up.16818665 2006
×
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
Primary malignant neoplasm
0.100
Biomarker
BEFREE
K-RAS mutation is being developed as a cancer biomarker and tumor K-RAS is being used to predict therapeutic response.20307197 2010
×
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
Primary malignant neoplasm
0.100
Biomarker
BEFREE
KRAS mutations are found at high frequencies in human colorectal cancer (CRC); however, KRAS -targeted cancer therapy has not been developed.20454511 2010
×
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
Primary malignant neoplasm
0.100
GeneticVariation
BEFREE
KRAS mutations exhibit significant predictive and prognostic value in cancer .21532494 2011
×
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
Primary malignant neoplasm
0.100
GeneticVariation
BEFREE
KRAS and BRAF mutations were significantly associated with the proximal location of cancer (p = 0.017 and 0.001, respectively).21553007 2011
×
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
Primary malignant neoplasm
0.100
GeneticVariation
BEFREE
KRAS mutations, detected in pancreatic cyst fluid, are associated with mucinous cysts and progression and development of malignancy and should be considered in assessing pancreatic cysts.23267865 2013
×
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
Primary malignant neoplasm
0.100
GeneticVariation
BEFREE
K‑ras gene mutation as a predictor of cancer cell responsiveness to metformin.23877793 2013
×
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
Primary malignant neoplasm
0.100
GeneticVariation
BEFREE
KRAS and BRAF mutations were analysed by pyrosequencing in tumours from 494 incident CRC cases in the Malmö Diet and Cancer Study.24918610 2014
×
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
Primary malignant neoplasm
0.100
GeneticVariation
BEFREE
KRAS is the most frequently mutated oncogene in human cancer , yet no therapies are available to treat KRAS mutant cancers.25199829 2014
×
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
Primary malignant neoplasm
0.100
GeneticVariation
BEFREE
KRAS mutation is common in human cancer .25313136 2014
×
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
Primary malignant neoplasm
0.100
GeneticVariation
BEFREE
KRAS is a frequently mutated gene in human cancer but remains a challenging clinical target.25389372 2014
×
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
Primary malignant neoplasm
0.100
GeneticVariation
BEFREE
KRAS gene mutations were detected in the cancer tissue of 24 cases (42.85%).25412182 2014
×
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
Primary malignant neoplasm
0.100
GeneticVariation
BEFREE
KRAS mutations were detected in pancreatic juice from larger percentages of subjects with pancreatic cancer (73%) or undergoing cancer screening (50%) than controls (19%) (P = .0005).25481712 2015
×
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
Primary malignant neoplasm
0.100
AlteredExpression
BEFREE
KRAS mutant colonic polyps and cancer tissue had significantly higher (3.04 fold, 95% CI=1.23-7.46) expression levels of hsa-miR-135b compared to polyps and cancers with non mutant KRAS gene (p=0.001).25496852 2015
×
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
Primary malignant neoplasm
0.100
Biomarker
BEFREE
KRAS proteins play a major role in human cancer , but have not yielded to therapeutic attack.25878360 2015
×
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
Primary malignant neoplasm
0.100
Biomarker
BEFREE
K-Ras promotes the non-small lung cancer cells survival by cooperating with sirtuin 1 and p27 under ROS stimulation.25894374 2015
×
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
Primary malignant neoplasm
0.100
GeneticVariation
BEFREE
KRAS and BRAF are among the most commonly mutated oncogenes in human cancer that contribute to tumorigenesis in both distinct and overlapping tissues.26028035 2016
×
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
Primary malignant neoplasm
0.100
GeneticVariation
BEFREE
KRAS mutations are the most common genetic abnormalities in cancer , but the distribution of specific mutations across cancers and the differential responses of patients with specific KRAS mutations in therapeutic clinical trials suggest that different KRAS mutations have unique biochemical behaviors.26037647 2015
×
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
Primary malignant neoplasm
0.100
Biomarker
BEFREE
K-Ras proteins are major drivers of human cancers, playing a direct causal role in about one million cancer cases/year.26960760 2016
×
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
Primary malignant neoplasm
0.100
GeneticVariation
BEFREE
KRAS codon 13 mutations, but not codon 12 mutations, were associated with a higher risk for overall extrahepatic recurrence and lung-specific recurrence.Cancer 2016.© 2016 American Cancer Society.Cancer 2016;122:2698-2707.© 2016 American Cancer Society.27244540 2016
×
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
Primary malignant neoplasm
0.100
GeneticVariation
BEFREE
KRAS is one of the most commonly mutated oncogenes in human cancer .27477280 2016