×
Entrez Id: 7852
Gene Symbol: CXCR4
CXCR4
Neoplasm Metastasis
0.400
AlteredExpression
BEFREE
<i>in-silico</i> analysis finds that CXCL12-CXCR4 is associated with an increased expression of PDZK1, PI3k and Akt which lead the breast tumor towards metastasis .
28929029 2017
×
Entrez Id: 7852
Gene Symbol: CXCR4
CXCR4
Neoplasm Metastasis
0.400
AlteredExpression
BEFREE
2) The expression levels of CXCR4 does not increase during local progression, however, CXCR4 expression increases the risk of distant metastases in HCC, OR = 5.84, 95% CI = 2.84-12.00, P < 0.00001.
26203228 2015
×
Entrez Id: 7852
Gene Symbol: CXCR4
CXCR4
Neoplasm Metastasis
0.400
AlteredExpression
BEFREE
64B inhibited hypoxia-induced expression of CXCR4 and c-Met, 2 key drivers of tumor invasion and metastasis .
30563937 2019
×
Entrez Id: 7852
Gene Symbol: CXCR4
CXCR4
Neoplasm Metastasis
0.400
Biomarker
BEFREE
Metastasis is an intricate process; one of the possible mechanisms is through the interaction of the chemokines CXCL12 and CXCR4 .29887884 2018
×
Entrez Id: 7852
Gene Symbol: CXCR4
CXCR4
Neoplasm Metastasis
0.400
Biomarker
BEFREE
CXCR4 is also expressed by carcinoma cells, and CXCR4 antibodies were recently shown to reduce metastasis of a mammary carcinoma cell line.12839981 2003
×
Entrez Id: 7852
Gene Symbol: CXCR4
CXCR4
Neoplasm Metastasis
0.400
AlteredExpression
BEFREE
CXCR4 expression was detected in 33 out of 63 (52.4%) metastases from cutaneous melanomas.16638848 2006
×
Entrez Id: 7852
Gene Symbol: CXCR4
CXCR4
Neoplasm Metastasis
0.400
Biomarker
BEFREE
Chemokine receptor CXCR4 (CD184 ) may play a role in cancer metastasis and is known to form homodimers.17041091 2006
×
Entrez Id: 7852
Gene Symbol: CXCR4
CXCR4
Neoplasm Metastasis
0.400
Biomarker
BEFREE
CXCR4 is a chemokine receptor that has been linked to breast cancer invasion and metastasis .18270814 2009
×
Entrez Id: 7852
Gene Symbol: CXCR4
CXCR4
Neoplasm Metastasis
0.400
Biomarker
BEFREE
Chemokine-receptor signaling plays an important role in the inflammatory response often associated with tumor growth and metastasis .19446734 2009
×
Entrez Id: 7852
Gene Symbol: CXCR4
CXCR4
Neoplasm Metastasis
0.400
Biomarker
BEFREE
CXCR4 is a chemokine receptor that has been linked to breast cancer invasion and metastasis .19500800 2010
×
Entrez Id: 7852
Gene Symbol: CXCR4
CXCR4
Neoplasm Metastasis
0.400
Biomarker
BEFREE
CXCR4 , a chemokine receptor , plays an important role in breast cancer growth, invasion, and metastasis .20603605 2010
×
Entrez Id: 7852
Gene Symbol: CXCR4
CXCR4
Neoplasm Metastasis
0.400
Biomarker
BEFREE
CXCR4 is generally regarded as a plasma membrane receptor where it transmits signals that support transformation, progression and eventual metastasis .23468933 2013
×
Entrez Id: 7852
Gene Symbol: CXCR4
CXCR4
Neoplasm Metastasis
0.400
Biomarker
BEFREE
CXCR4 silenced by siRNA could suppress the proliferation, invasion and metastasis of esophageal carcinoma cell lines KYSE-150 and TE-13 in vitro and in vivo.23800042 2013
×
Entrez Id: 7852
Gene Symbol: CXCR4
CXCR4
Neoplasm Metastasis
0.400
Biomarker
BEFREE
CXCR4 is a chemokine receptor that mediates invasion and metastasis .23918819 2013
×
Entrez Id: 7852
Gene Symbol: CXCR4
CXCR4
Neoplasm Metastasis
0.400
Biomarker
BEFREE
CXCR4 has been proved to play an important role in the process of tumor metastasis .24150861 2013
×
Entrez Id: 7852
Gene Symbol: CXCR4
CXCR4
Neoplasm Metastasis
0.400
Biomarker
BEFREE
CXCR4 is a marker of poor prognosis in various neoplasms, correlating with metastatic disease and decreased survival of patients.25231113 2015
×
Entrez Id: 7852
Gene Symbol: CXCR4
CXCR4
Neoplasm Metastasis
0.400
Biomarker
BEFREE
Chemokine receptor CXCR4 is involved in tumor growth, angiogenesis and metastasis .26321665 2015
×
Entrez Id: 7852
Gene Symbol: CXCR4
CXCR4
Neoplasm Metastasis
0.400
AlteredExpression
BEFREE
CXCR4 and CXCR7 expressions in metastasis tumor were also higher, although no significant difference was observed (P=0.067 and P=0.054, respectively).26722521 2015
×
Entrez Id: 7852
Gene Symbol: CXCR4
CXCR4
Neoplasm Metastasis
0.400
Biomarker
BEFREE
CXCR4 knockdown or treatment with AMD3100, a CXCR4 inhibitor, attenuated RUNX2-promoted invasion and metastasis .27007162 2016
×
Entrez Id: 7852
Gene Symbol: CXCR4
CXCR4
Neoplasm Metastasis
0.400
Biomarker
BEFREE
Chemokine (C-X-C motif) receptor 4 (CXCR4 ) is a key factor for tumor growth and metastasis in several types of human cancer including multiple myeloma (MM).28042328 2017
×
Entrez Id: 7852
Gene Symbol: CXCR4
CXCR4
Neoplasm Metastasis
0.400
Biomarker
BEFREE
CXCR4 possesses a critical role in several intracellular events such as chemotaxis, invasion and adhesion, which are associated with metastasis of cancer cell.28215173 2017
×
Entrez Id: 7852
Gene Symbol: CXCR4
CXCR4
Neoplasm Metastasis
0.400
Biomarker
BEFREE
C-X-C-motif chemokine receptor 4 (CXCR4 ) is a key factor for tumor growth and metastasis in several types of human cancer.28529638 2017
×
Entrez Id: 7852
Gene Symbol: CXCR4
CXCR4
Neoplasm Metastasis
0.400
AlteredExpression
BEFREE
C-X-C motif chemokine receptor 4 (CXCR4 ) overexpression promotes gastric cancer growth and metastasis .28544312 2017
×
Entrez Id: 7852
Gene Symbol: CXCR4
CXCR4
Neoplasm Metastasis
0.400
Biomarker
BEFREE
Chemokine receptor 4 (CXCR4 ) and its chemokine ligand 12 (CXCL12) have been identified with significantly elevated levels in various malignancies including GC, which correlates with the survival, proliferation, angiogenesis, and metastasis of tumor cells.28544785 2017
×
Entrez Id: 7852
Gene Symbol: CXCR4
CXCR4
Neoplasm Metastasis
0.400
Biomarker
BEFREE
C-X-C chemokine receptor type 4 and stromal cell-derived factor-1 were proven to play important roles in several types of cancer and in many biological processes connected with tumor growth, invasion, angiogenesis, and metastasis .28621237 2017