Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.100 AlteredExpression BEFREE Disappointing results in chemotherapy of glioblastomas resulting from multi-drug resistance (MDR) prompted us to investigate the influence of cytokine gene transfer in glioblastoma cells on the expression of P-glycoprotein and on chemosensitivity of transduced cells. 7790119

1995

Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.100 Biomarker BEFREE In this report, we show that the mdm2 (murine double minute 2) gene induced the expression of the mdr1 gene and P-gp in human glioblastoma U87-MG cells, which did not express the MDM2 protein or P-gp. 8883415

1996

Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.100 Biomarker BEFREE No induction of mdr1 was observed in some early astrocytoma or glioblastoma cell cultures even after administration of high concentrations of the drugs ACNU and VM26, often used in glioma therapy. 9020393

1997

Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.100 Biomarker BEFREE We have compared the effect on the expression of P-glycoprotein (Pgp), the MDR1 gene product, on vinblastine resistance in two glioblastoma lines, U87 and U251, grown as either monolayers or spheroids. 9413166

1998

Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.100 Biomarker BEFREE NQO may be a priority target of glioblastoma chemotherapy suitable for biochemical nature of the cells, and expression analysis of NQO1, alpha-TUB, beta-TUB, MGMT, MDR1 and GSTpi may help to seek a truly active drug against glioblastomas. 10639573

2000

Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.100 Biomarker BEFREE Here, we examined the role of the multidrug resistance (mdr) mechanism in the chemo-resistance of these tumors, using a twofold approach: (i) by assessing a possible mdr phenotype before and after chronic drug exposure of glioma cells in vitro, and (ii) by assessing the modulation of expression of the mdr-associated P-glycoprotein (Pgp) using radiotherapy and serial cycles of chemotherapy in human glioblastoma patients in vivo. 10805101

2000

Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.100 AlteredExpression BEFREE In the present study, MDR1 P-gp was immunodetected by Western blot analysis in 60 human brain tumors, including meningiomas, schwannomas, low-grade gliomas (astrocytomas, pilocytic astrocytomas) and high-grade gliomas (anaplastic astrocytomas, glioblastomas and anaplastic oligodendrogliomas). 11391622

2001

Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.100 AlteredExpression BEFREE Molecular and functional MDR1-Pgp and MRPs expression in human glioblastoma multiforme cell lines. 11857404

2002

Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.100 AlteredExpression BEFREE We found that a considerable expression of P-gp was relatively rare in glioma cells, in contrast to MRP1, which was constitutively overexpressed in cells derived from astrocytomas as well as glioblastomas. 12125964

2002

Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.100 AlteredExpression BEFREE Brain vessels extracted from tissue sections of nonmalignant human brain and glioblastoma tumors by laser capture microdissection microscopy and analyzed by real-time polymerase chain reaction showed higher expression of ABCG2 relative to ABCB1/MDR1 and ABCC1/MRP1. 12958161

2003

Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.100 AlteredExpression BEFREE The aim of the present investigations was to reduce the expression of P-gp in the human glioblastoma cell line U-87 MG and in the human endothelial cell line HUV-ECC. 15051924

2004

Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.100 GeneticVariation BEFREE Although the C3435T polymorphism does not appear to be associated with other types of glioma, we cannot rule out that this MDR1 polymorphism may be associated with glioblastoma among men. 15947495

2005

Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.100 AlteredExpression LHGDN CD133 (stem marker) and drug resistant gene (mdr1 and bcl-2) expression were detected in human glioblastoma and normal brain tissues. 18568776

2008

Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.100 AlteredExpression BEFREE CD133 (stem marker) and drug resistant gene (mdr1 and bcl-2) expression were detected in human glioblastoma and normal brain tissues. 18568776

2008

Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.100 GeneticVariation BEFREE We aimed to confirm first that temozolomide is a target for the multidrug resistance transporter MDR1/ABCB1 and second to investigate whether genetic variants of the MDR1 gene are associated with the survival of glioblastoma patients treated with temozolomide. 18687982

2009

Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.100 GeneticVariation LHGDN Genotypes of three single nucleotide polymorphisms (SNPs) of the MDR1 gene (C1236T, G2677T, and C3435T), MDR1 mRNA expression levels, and the MGMT promoter methylation status were analyzed in 112 glioblastoma patients who had been treated either by surgery plus radiotherapy alone or by additional temozolomide chemotherapy. 18687982

2009

Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.100 AlteredExpression BEFREE Interestingly, ABCB1 levels of expression diminished in SF188. 18946672

2009

Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.100 Biomarker BEFREE Prognostic significance of the immunohistochemical expression of O6-methylguanine-DNA methyltransferase, P-glycoprotein, and multidrug resistance protein-1 in glioblastomas. 19019175

2009

Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.100 Biomarker BEFREE In addition, we identified the crossreactivity of CD133 and MDR1 in a surgical specimen of GBM. 19832037

2009

Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.100 AlteredExpression BEFREE In conclusion, continuous PTX treatment caused the over-expression of P-gp and acquisition of MDR in colon cancer and glioblastoma cell lines, while some mechanisms of MDR and tumor progression such as GSH detoxification system and VEGF secretion were suppressed. 21775090

2011

Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.100 Biomarker BEFREE We examined the effects of sulfinosine (SF), a quite unexplored purine nucleoside analog, in MDR (P-gp over-expressing) non-small cell lung carcinoma (NSCLC) and glioblastoma cell lines (NCI-H460/R and U87-TxR, respectively). 23326571

2013

Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.100 Biomarker BEFREE Epigenetic modulation of the drug resistance genes MGMT, ABCB1 and ABCG2 in glioblastoma multiforme. 24380367

2013

Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.100 AlteredExpression BEFREE We found that Wnt3a and ABCB1, which encodes for Pgp, were both highly expressed in glioblastoma stem cells and reduced by temozolomide. 23897632

2013

Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.100 AlteredExpression BEFREE Temozolomide induces the production of epidermal growth factor to regulate MDR1 expression in glioblastoma cells. 25053824

2014

Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.100 Biomarker BEFREE We used genetically engineered spontaneous glioblastoma mouse models and allograft models that were orthotopically transplanted into wild-type (WT) and Abcb1/Abcg2-deficient (KO) recipients. 24647572

2014