×
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
Colorectal Carcinoma
0.500
GeneticVariation
BEFREE
These findings suggest that PPARgamma gene polymorphism may be implicated with the development of colorectal cancers , in which K-ras gene is not mutated.
11956653 2002
×
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
Colorectal Carcinoma
0.500
GeneticVariation
BEFREE
In this study, we evaluated the association between colorectal cancer and specific tumor mutations and the Pro12Ala (P12A ) PPARgamma polymorphism.
16489531 2006
×
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
Colorectal Carcinoma
0.500
GeneticVariation
BEFREE
On the contrary, two other SNPs, PLA2G2A c.435+230C>T and PPARG c.1431C>T (p.His477His ), were associated with a decrease in CRC risk.
18992148 2008
×
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
Colorectal Carcinoma
0.500
GeneticVariation
BEFREE
Meat, milk, saturated fatty acids, the Pro12Ala and C161T polymorphisms of the PPARgamma gene and colorectal cancer risk in Japanese.
16965392 2006
×
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
Colorectal Carcinoma
0.500
GeneticVariation
BEFREE
Red meat intake, CYP2E1 and PPARγ polymorphisms, and colorectal cancer risk.
30489355 2019
×
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
Colorectal Carcinoma
0.500
GeneticVariation
BEFREE
This meta-analysis suggests that the Ala allele of the PPARgamma P12A polymorphism might be a protective factor for colorectal cancer , but a risk factor for gastric cancer.
20596649 2010
×
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
Colorectal Carcinoma
0.500
GeneticVariation
BEFREE
The current meta-analysis has established that ADH1B (rs1229984 ) and PPARG (rs1801282 ) are two risk variants of CRC .
24552298 2014
×
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
Colorectal Carcinoma
0.500
GeneticVariation
BEFREE
Our results provide new evidence of association between PPARG variants and colorectal cancer risk.
24045924 2013
×
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
Colorectal Carcinoma
0.500
GeneticVariation
BEFREE
Further, somatic loss of function mutations in PPARgamma have been found in primary colorectal carcinomas .
10851250 2000
×
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
Colorectal Carcinoma
0.500
GeneticVariation
BEFREE
There was no evidence for the association between PPAR-gamma 34 C>G and CRC if all of the subjects in the nine studies were included.
20440859 2010
×
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
Colorectal Carcinoma
0.500
GeneticVariation
BEFREE
Mutations in PPARG have also been reported in sporadic colorectal cancers , but the significance of these mutations is unclear.
30595551 2019
×
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
Colorectal Carcinoma
0.500
GeneticVariation
BEFREE
We studied the association of SNPs in the IL-6 (-174G>C), IL-8 (-251T>A), TNFalpha (-308G>A), ICAM-1 (R241G and K469E ), and PPARgamma (Pro12Ala ) genes and the risk of CRC .
16937502 2006
×
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
Colorectal Carcinoma
0.500
GeneticVariation
BEFREE
We report a novel PPARG germline mutation in a patient affected by colorectal cancer that replaces serine 289 with cysteine in the mature protein (S289C ).
20123124 2010
×
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
Colorectal Carcinoma
0.500
GeneticVariation
BEFREE
Further research is needed to investigate functional implications of polymorphisms of the PPAR-gamma gene in CRC development.
16108832 2005
×
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
Colorectal Carcinoma
0.500
Biomarker
BEFREE
The ability to counteract PPARgamma suggests that gammaORF4 plays a role in the pathogenesis of colorectal cancers .
15857827 2005
×
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
Colorectal Carcinoma
0.500
Biomarker
BEFREE
These findings suggest that the relationship between UHRF1 and PPARG may have a relevant role in CRC progression.
22286757 2012
×
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
Colorectal Carcinoma
0.500
Biomarker
BEFREE
This is the first report that IL6, IL8, and PPARG genes are important in relation to inflammation-related risk of sporadic CRC .
12839942 2003
×
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
Colorectal Carcinoma
0.500
Biomarker
BEFREE
In summary, we identified a panel of proteins correlated with PPARγ expression that could be associated with CRC unveiling new pathways to be investigated for the selection of novel potential prognostic/predictive biomarkers and/or therapeutic targets.
27499265 2016
×
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
Colorectal Carcinoma
0.500
Biomarker
BEFREE
PPARgamma agonists have been shown to reduce the growth of colorectal carcinoma cells in culture and in xenograft models.17390024 2007
×
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
Colorectal Carcinoma
0.500
Biomarker
BEFREE
Here, we found that 15-hydroxy-eicosatetraenoic acid (15S-HETE), an endogenous ligand for PPARgamma , was significantly decreased in the serum of patients with colorectal cancer .
14566836 2003
×
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
Colorectal Carcinoma
0.500
Biomarker
BEFREE
Ensemble of gene signatures identifies novel biomarkers in colorectal cancer activated through PPARγ and TNFα signaling.
24133572 2013
×
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
Colorectal Carcinoma
0.500
Biomarker
BEFREE
The combination of resveratrol with a PPARγ agonist could be a promising pharmacological approach for treatment of colorectal cancer .
24975132 2014
×
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
Colorectal Carcinoma
0.500
Biomarker
BEFREE
Interactions of peroxisome proliferator-activated receptor {gamma } and diet in etiology of colorectal cancer .
15894676 2005
×
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
Colorectal Carcinoma
0.500
Biomarker
BEFREE
Luteolin potentiates the sensitivity of colorectal cancer cell lines to oxaliplatin through the PPARγ /OCTN2 pathway.
25075794 2014
×
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
Colorectal Carcinoma
0.500
Biomarker
BEFREE
Peroxisome proliferator-activated receptor gamma (PPAR(gamma) ) ligands inhibit cell growth of colorectal cancer cells in most experimental models, but no significant effect could be observed in patients with colorectal cancer .15911106 2005