Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.500 CausalMutation CLINVAR

Entrez Id: 5468
Gene Symbol: PPARG
PPARG
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.500 GeneticVariation BEFREE Further, somatic loss of function mutations in PPARgamma have been found in primary colorectal carcinomas. 10851250

2000

Entrez Id: 5468
Gene Symbol: PPARG
PPARG
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.500 GeneticVariation BEFREE These findings suggest that PPARgamma gene polymorphism may be implicated with the development of colorectal cancers, in which K-ras gene is not mutated. 11956653

2002

Entrez Id: 5468
Gene Symbol: PPARG
PPARG
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.500 AlteredExpression BEFREE Human colorectal cancer cell lines SW480 and HCT116 both expressed functional PPARgamma. 12606626

2003

Entrez Id: 5468
Gene Symbol: PPARG
PPARG
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.500 AlteredExpression BEFREE Each colorectal carcinoma cell line expressed PPARgamma. 12711249

2003

Entrez Id: 5468
Gene Symbol: PPARG
PPARG
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.500 Biomarker BEFREE This is the first report that IL6, IL8, and PPARG genes are important in relation to inflammation-related risk of sporadic CRC. 12839942

2003

Entrez Id: 5468
Gene Symbol: PPARG
PPARG
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.500 Biomarker BEFREE Here, we found that 15-hydroxy-eicosatetraenoic acid (15S-HETE), an endogenous ligand for PPARgamma, was significantly decreased in the serum of patients with colorectal cancer. 14566836

2003

Entrez Id: 5468
Gene Symbol: PPARG
PPARG
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.500 AlteredExpression BEFREE PPARG, the gene encoding the gamma isoform of the peroxisome proliferator-activated receptor (PPARgamma), is highly expressed in normal human pancreatic islet cells, is located at 3p25, and has been reported to sustain loss-of-function mutations in human colorectal carcinomas. 15853832

2005

Entrez Id: 5468
Gene Symbol: PPARG
PPARG
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.500 Biomarker BEFREE The ability to counteract PPARgamma suggests that gammaORF4 plays a role in the pathogenesis of colorectal cancers. 15857827

2005

Entrez Id: 5468
Gene Symbol: PPARG
PPARG
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.500 Biomarker BEFREE Interactions of peroxisome proliferator-activated receptor {gamma} and diet in etiology of colorectal cancer. 15894676

2005

Entrez Id: 5468
Gene Symbol: PPARG
PPARG
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.500 Biomarker BEFREE Peroxisome proliferator-activated receptor gamma (PPAR(gamma)) ligands inhibit cell growth of colorectal cancer cells in most experimental models, but no significant effect could be observed in patients with colorectal cancer. 15911106

2005

Entrez Id: 5468
Gene Symbol: PPARG
PPARG
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.500 GeneticVariation BEFREE Further research is needed to investigate functional implications of polymorphisms of the PPAR-gamma gene in CRC development. 16108832

2005

Entrez Id: 5468
Gene Symbol: PPARG
PPARG
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.500 Biomarker BEFREE No evidence that polymorphisms in CYP2C8, CYP2C9, UGT1A6, PPARdelta and PPARgamma act as modifiers of the protective effect of regular NSAID use on the risk of colorectal carcinoma. 16141797

2005

Entrez Id: 5468
Gene Symbol: PPARG
PPARG
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.500 GeneticVariation BEFREE In this study, we evaluated the association between colorectal cancer and specific tumor mutations and the Pro12Ala (P12A) PPARgamma polymorphism. 16489531

2006

Entrez Id: 5468
Gene Symbol: PPARG
PPARG
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.500 Biomarker CTD_human In this study, we evaluated the association between colorectal cancer and specific tumor mutations and the Pro12Ala (P12A) PPARgamma polymorphism. 16489531

2006

Entrez Id: 5468
Gene Symbol: PPARG
PPARG
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.500 AlteredExpression BEFREE RT-PCR and Western blot analysis showed that both human CRC cell lines expressed PPARgamma mRNA and protein. 16520894

2006

Entrez Id: 5468
Gene Symbol: PPARG
PPARG
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.500 GeneticVariation BEFREE We studied the association of SNPs in the IL-6 (-174G>C), IL-8 (-251T>A), TNFalpha (-308G>A), ICAM-1 (R241G and K469E), and PPARgamma (Pro12Ala) genes and the risk of CRC. 16937502

2006

Entrez Id: 5468
Gene Symbol: PPARG
PPARG
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.500 GeneticVariation BEFREE Meat, milk, saturated fatty acids, the Pro12Ala and C161T polymorphisms of the PPARgamma gene and colorectal cancer risk in Japanese. 16965392

2006

Entrez Id: 5468
Gene Symbol: PPARG
PPARG
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.500 Biomarker BEFREE PPARgamma inhibitors also reduced CRC cell migration and invasion in assays in vitro and reduced both the number and size of metastases in a HT-29/SCID xenograft metastatic model of CRC. 17096328

2007

Entrez Id: 5468
Gene Symbol: PPARG
PPARG
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.500 AlteredExpression BEFREE The purpose of this study was to evaluate whether EP(1-4) subtype, PPAR gamma receptor and COX-1/COX-2 expression in colorectal cancer are related to tumor-specific mortality. 17290397

2007

Entrez Id: 5468
Gene Symbol: PPARG
PPARG
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.500 Biomarker BEFREE PPARgamma agonists have been shown to reduce the growth of colorectal carcinoma cells in culture and in xenograft models. 17390024

2007

Entrez Id: 5468
Gene Symbol: PPARG
PPARG
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.500 Biomarker BEFREE Although PPARgamma agonists may not by themselves be capable to induce clinical tumor regression, their combination with chemotherapy drugs or other targeted therapies is worth pursuing in the treatment of colorectal carcinoma. 17659359

2007

Entrez Id: 5468
Gene Symbol: PPARG
PPARG
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.500 Biomarker BEFREE Farnesol (FOH) and geranylgeraniol (GGOH) possess anti-tumor potential, while peroxisome proliferator-activated receptor gamma (PPARgamma) has exhibited modulating effects in colorectal cancers. 18608213

2008

Entrez Id: 5468
Gene Symbol: PPARG
PPARG
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.500 GeneticVariation BEFREE On the contrary, two other SNPs, PLA2G2A c.435+230C>T and PPARG c.1431C>T (p.His477His), were associated with a decrease in CRC risk. 18992148

2008

Entrez Id: 5468
Gene Symbol: PPARG
PPARG
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.500 AlteredExpression BEFREE Influence of tumor peroxisome proliferator-activated receptor gamma and delta expression on postoperative mortality of patients undergoing colorectal cancer surgery. 19283612

2009