Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.500 CausalMutation CLINVAR

Entrez Id: 5468
Gene Symbol: PPARG
PPARG
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.500 Biomarker BEFREE <b>Purpose:</b> Functional variants in the <i>peroxisome proliferator-activated receptor gamma</i> (<i>PPARG</i>) and <i>PPARG co-activator 1</i> (<i>PPARGC1</i>) family (e.g., <i>PPARGC1A</i> and <i>PPARGC1B</i>) genes were predicted to confer susceptibility to colorectal cancer (CRC). 30838172

2019

Entrez Id: 5468
Gene Symbol: PPARG
PPARG
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.500 AlteredExpression BEFREE PPARG, the gene encoding the gamma isoform of the peroxisome proliferator-activated receptor (PPARgamma), is highly expressed in normal human pancreatic islet cells, is located at 3p25, and has been reported to sustain loss-of-function mutations in human colorectal carcinomas. 15853832

2005

Entrez Id: 5468
Gene Symbol: PPARG
PPARG
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.500 Biomarker BEFREE Peroxisome proliferator-activated receptor gamma (PPAR(gamma)) ligands inhibit cell growth of colorectal cancer cells in most experimental models, but no significant effect could be observed in patients with colorectal cancer. 15911106

2005

Entrez Id: 5468
Gene Symbol: PPARG
PPARG
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.500 Biomarker BEFREE PPARgamma inhibitors also reduced CRC cell migration and invasion in assays in vitro and reduced both the number and size of metastases in a HT-29/SCID xenograft metastatic model of CRC. 17096328

2007

Entrez Id: 5468
Gene Symbol: PPARG
PPARG
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.500 Biomarker BEFREE PPARgamma agonists have been shown to reduce the growth of colorectal carcinoma cells in culture and in xenograft models. 17390024

2007

Entrez Id: 5468
Gene Symbol: PPARG
PPARG
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.500 Biomarker BEFREE Although PPARgamma agonists may not by themselves be capable to induce clinical tumor regression, their combination with chemotherapy drugs or other targeted therapies is worth pursuing in the treatment of colorectal carcinoma. 17659359

2007

Entrez Id: 5468
Gene Symbol: PPARG
PPARG
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.500 AlteredExpression BEFREE Each colorectal carcinoma cell line expressed PPARgamma. 12711249

2003

Entrez Id: 5468
Gene Symbol: PPARG
PPARG
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.500 Biomarker BEFREE Ensemble of gene signatures identifies novel biomarkers in colorectal cancer activated through PPARγ and TNFα signaling. 24133572

2013

Entrez Id: 5468
Gene Symbol: PPARG
PPARG
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.500 Biomarker BEFREE Farnesol (FOH) and geranylgeraniol (GGOH) possess anti-tumor potential, while peroxisome proliferator-activated receptor gamma (PPARgamma) has exhibited modulating effects in colorectal cancers. 18608213

2008

Entrez Id: 5468
Gene Symbol: PPARG
PPARG
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.500 GeneticVariation BEFREE Further research is needed to investigate functional implications of polymorphisms of the PPAR-gamma gene in CRC development. 16108832

2005

Entrez Id: 5468
Gene Symbol: PPARG
PPARG
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.500 GeneticVariation BEFREE Further, somatic loss of function mutations in PPARgamma have been found in primary colorectal carcinomas. 10851250

2000

Entrez Id: 5468
Gene Symbol: PPARG
PPARG
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.500 Biomarker BEFREE Here, we analyzed a series of chiral phenoxyacetic acid analogues for their ability to inhibit colorectal cancer (CRC) cells growth by binding PPARγ as partial agonists as assessed in transactivation assays of a PPARG-reporter gene. 30931956

2019

Entrez Id: 5468
Gene Symbol: PPARG
PPARG
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.500 Biomarker BEFREE Here, we found that 15-hydroxy-eicosatetraenoic acid (15S-HETE), an endogenous ligand for PPARgamma, was significantly decreased in the serum of patients with colorectal cancer. 14566836

2003

Entrez Id: 5468
Gene Symbol: PPARG
PPARG
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.500 Biomarker BEFREE Here, we provide the first evidence that elevated PPARδ expression and/or activation of PPARδ antagonize the ability of PPARγ to induce colorectal carcinoma cell death. 21765467

2012

Entrez Id: 5468
Gene Symbol: PPARG
PPARG
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.500 AlteredExpression BEFREE Human colorectal cancer cell lines SW480 and HCT116 both expressed functional PPARgamma. 12606626

2003

Entrez Id: 5468
Gene Symbol: PPARG
PPARG
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.500 AlteredExpression BEFREE In conclusion, SOX9, β-catenin and PPARγ expression levels are deregulated in the CRC tissue, and in colon cancer cell lines ligand-dependent PPARγ activation unevenly influences SOX9 and β-catenin expression and subcellular localization, suggesting a variable mechanistic role in colon carcinogenesis. 23583560

2013

Entrez Id: 5468
Gene Symbol: PPARG
PPARG
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.500 Biomarker BEFREE In summary, we identified a panel of proteins correlated with PPARγ expression that could be associated with CRC unveiling new pathways to be investigated for the selection of novel potential prognostic/predictive biomarkers and/or therapeutic targets. 27499265

2016

Entrez Id: 5468
Gene Symbol: PPARG
PPARG
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.500 GeneticVariation BEFREE In this study, we evaluated the association between colorectal cancer and specific tumor mutations and the Pro12Ala (P12A) PPARgamma polymorphism. 16489531

2006

Entrez Id: 5468
Gene Symbol: PPARG
PPARG
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.500 Biomarker CTD_human In this study, we evaluated the association between colorectal cancer and specific tumor mutations and the Pro12Ala (P12A) PPARgamma polymorphism. 16489531

2006

Entrez Id: 5468
Gene Symbol: PPARG
PPARG
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.500 AlteredExpression BEFREE In this study, we examined whether the expression of NFATc2 and PPARG genes is significantly altered during the carcinogenesis of CRC. 28504924

2017

Entrez Id: 5468
Gene Symbol: PPARG
PPARG
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.500 AlteredExpression BEFREE Influence of tumor peroxisome proliferator-activated receptor gamma and delta expression on postoperative mortality of patients undergoing colorectal cancer surgery. 19283612

2009

Entrez Id: 5468
Gene Symbol: PPARG
PPARG
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.500 Biomarker BEFREE Interactions of peroxisome proliferator-activated receptor {gamma} and diet in etiology of colorectal cancer. 15894676

2005

Entrez Id: 5468
Gene Symbol: PPARG
PPARG
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.500 Biomarker BEFREE Luteolin potentiates the sensitivity of colorectal cancer cell lines to oxaliplatin through the PPARγ/OCTN2 pathway. 25075794

2014

Entrez Id: 5468
Gene Symbol: PPARG
PPARG
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.500 GeneticVariation BEFREE Meat, milk, saturated fatty acids, the Pro12Ala and C161T polymorphisms of the PPARgamma gene and colorectal cancer risk in Japanese. 16965392

2006