Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 GeneticVariation BEFREE The methylation level of the p16 gene was also associated with the presence of intestinal-type gastric cancer (p = 0.017). 17438355

2007

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 Biomarker BEFREE We suggest that the carcinogenesis of EBV-associated gastric cancers may be closely associated with a p16 abnormality. 16619489

2006

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 Biomarker BEFREE E2F promoter-regulated oncolytic adenovirus with p16 gene induces cell apoptosis and exerts antitumor effect on gastric cancer. 19034663

2009

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 AlteredExpression BEFREE The Aζ value of the receiver-operator characteristic curve for methylated p16 was 0.899 for serum and PPWs, compared to that in GC tissues. 24817951

2014

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 PosttranslationalModification BEFREE Aberrant p16 methylation was found in 23 of 60 (38%) primary gastric cancers, but in none of the corresponding gastric mucosae. 12824886

2003

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 Biomarker BEFREE These results suggest that p16(INK4a) promoter hypermethylation is an early and frequent event in gastric carcinogenesis and may serve as a new prognostic biomarker for the risk of gastric cancers. 11477571

2001

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 GeneticVariation BEFREE Intragenic homozygous deletions of MTS1 gene in gastric cancer in Taiwan. 8957063

1996

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 AlteredExpression BEFREE Therefore, alteration and heterozygous expression of CDKN2 appears to be involved in the pathogenesis of human gastric cancers. 9139866

1997

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 PosttranslationalModification BEFREE The results suggest that hypermethylation and abnormality of p16 gene may play a key role in the progress of gastric cancer. 12632489

2003

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 Biomarker BEFREE Up-regulation of activation-induced cytidine deaminase causes genetic aberrations at the CDKN2b-CDKN2a in gastric cancer. 20637757

2010

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 PosttranslationalModification BEFREE The objective of this study was to investigate the contribution of p16 inactivation in gastric cancer and to compare it with p53. 12469165

2003

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 PosttranslationalModification BEFREE We aimed to evaluate the inactivation of COX-2, HMLH1 and CDKN2A by promoter methylation and its relationship with the infection by different Helicobacter pylori strains in gastric cancer. 21849808

2011

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 PosttranslationalModification BEFREE Methylation status of ANAPC1, CDKN2A and TP53 promoter genes in individuals with gastric cancer. 18622497

2008

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 AlteredExpression BEFREE Relative expression of SNHG7 is upregulated in gastric cancer tissues and cells, and partially contributes to the development and progression of gastric cancer through regulation of p15 and p16 expressions. 29131253

2017

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 Biomarker BEFREE Cytotoxicity of 5-Aza-2'-deoxycytidine against gastric cancer involves DNA damage in an ATM-P53 dependent signaling pathway and demethylation of P16(INK4A). 23201008

2013

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 PosttranslationalModification BEFREE The relationship between P16 gene promoter methylation and gastric cancer: a meta-analysis based on Chinese patients. 25693938

2014

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 AlteredExpression BEFREE Our results demonstrate that STAT3, but not STAT5, is involved in GC cell growth and cell cycle progression through regulation of gene expression, such as Bcl-2, p16(ink4a) and p21(waf1/cip1). 22328012

2012

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 PosttranslationalModification BEFREE Low serum IL-6 levels were associated with p16 or DAPK gene methylation in patients with gastric cancer. 17139167

2006

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 Biomarker BEFREE Evaluating LINE-1, TP53 and p16 jointly yielded a more pronounced negative association with gastric cancer (OR: 0.24; 95% CI: 0.09-0.66).Age was a significant effect modifier. 22126203

2011

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 Biomarker BEFREE Long noncoding RNA PVT1 indicates a poor prognosis of gastric cancer and promotes cell proliferation through epigenetically regulating p15 and p16. 25890171

2015

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 Biomarker BEFREE In the present study, we investigated the 5' CpG island hypermethylation of hMLH1, E-cadherin and p16 in 61 primary gastric cancers (GCs) by using combined bisulfite restriction analysis (COBRA) and methylation-specific PCR (MSP), and their MSI status. 10495421

1999

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 Biomarker BEFREE No precursor lesions were available from the gastric cancers that had loss of both MTAP and p16. 16224217

2005

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 Biomarker BEFREE The present study demonstrated for the first time that gastric cancer patients with p16INK4a methylation specifically benefit from 5-FU-based adjuvant chemotherapy. 18008030

2007

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 GeneticVariation BEFREE Overall, 78% of GC cases harbored one clinically relevant GA or more, with the most frequent alterations being found in TP53 (50%), ARID1A (24%), KRAS (16%), CDH1 (15%), CDKN2A (14%), CCND1 (9.5%), ERBB2 (8.5%), PIK3CA (8.6%), MLL2 (6.9%), FGFR2 (6.0%), and MET (6.0%). 25882375

2015

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 GeneticVariation BEFREE To explore germline hypermethylation of the tumor suppressor genes MLH1, CDH1 and P16(INK4a) in suspected cases of hereditary gastric cancer (GC). 22228973

2012