Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 GeneticVariation BEFREE Intragenic homozygous deletions of MTS1 gene in gastric cancer in Taiwan. 8957063

1996

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 AlteredExpression BEFREE Therefore, alteration and heterozygous expression of CDKN2 appears to be involved in the pathogenesis of human gastric cancers. 9139866

1997

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 Biomarker BEFREE In the present study, we investigated the 5' CpG island hypermethylation of hMLH1, E-cadherin and p16 in 61 primary gastric cancers (GCs) by using combined bisulfite restriction analysis (COBRA) and methylation-specific PCR (MSP), and their MSI status. 10495421

1999

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 Biomarker BEFREE In an effort to explore the underlying mechanism for the p16(INK4)-negative cases, a prospective study was also performed on 20 cases of gastric cancer to compare the level of the p16(INK4) protein with the methylation status of the p16(INK4) promoter. 10705239

2000

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 Biomarker BEFREE These results suggest that p16(INK4a) promoter hypermethylation is an early and frequent event in gastric carcinogenesis and may serve as a new prognostic biomarker for the risk of gastric cancers. 11477571

2001

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 GeneticVariation BEFREE Expression, deletion [was deleton] and mutation of p16 gene in human gastric cancer. 11819820

2001

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 AlteredExpression BEFREE The overexpression of p16 seems to be a common event in the development of both intestinal and diffuse type of gastric cancer and it is likely that it may be driven by features of the neoplastic state. 12145426

2002

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 PosttranslationalModification BEFREE Aberrant p16 methylation was found in 23 of 60 (38%) primary gastric cancers, but in none of the corresponding gastric mucosae. 12824886

2003

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 PosttranslationalModification BEFREE The results suggest that hypermethylation and abnormality of p16 gene may play a key role in the progress of gastric cancer. 12632489

2003

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 PosttranslationalModification BEFREE The objective of this study was to investigate the contribution of p16 inactivation in gastric cancer and to compare it with p53. 12469165

2003

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 GeneticVariation BEFREE The frequencies of LOH in two microsatellite sites, D9s171 and D9s1604, in p16 genome were associated with development of gastric cancer and no significant correlation was demonstrated between the LOH frequency and the cell differentiated types of tumor cells or clinical stages. 12632492

2003

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 Biomarker BEFREE To investigate the expression of human telomerase reverse transcriptase gene (hTRT) in gastric cancer (GC) and its relevance with cell cycle regulators including P16INK4, cyclin and P53. 12632490

2003

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 PosttranslationalModification BEFREE p16(INK4a) and p14(ARF) genes are frequently inactivated by homozygous deletion and methylation of the 5'CpG islands in gastric cancer, which may play an important role in the carcinogenesis of gastric cancer. 12890389

2003

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 AlteredExpression BEFREE 5-Aza-2'-deoxycitydine induces demethylation and up-regulates transcription of p16INK4A gene in human gastric cancer cell lines. 14733783

2004

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 Biomarker BEFREE No precursor lesions were available from the gastric cancers that had loss of both MTAP and p16. 16224217

2005

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 Biomarker BEFREE We suggest that the carcinogenesis of EBV-associated gastric cancers may be closely associated with a p16 abnormality. 16619489

2006

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 PosttranslationalModification BEFREE Low serum IL-6 levels were associated with p16 or DAPK gene methylation in patients with gastric cancer. 17139167

2006

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 GeneticVariation BEFREE The methylation level of the p16 gene was also associated with the presence of intestinal-type gastric cancer (p = 0.017). 17438355

2007

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 Biomarker BEFREE The present study demonstrated for the first time that gastric cancer patients with p16INK4a methylation specifically benefit from 5-FU-based adjuvant chemotherapy. 18008030

2007

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 PosttranslationalModification BEFREE Methylation status of ANAPC1, CDKN2A and TP53 promoter genes in individuals with gastric cancer. 18622497

2008

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 Biomarker BEFREE E2F promoter-regulated oncolytic adenovirus with p16 gene induces cell apoptosis and exerts antitumor effect on gastric cancer. 19034663

2009

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 Biomarker BEFREE Up-regulation of activation-induced cytidine deaminase causes genetic aberrations at the CDKN2b-CDKN2a in gastric cancer. 20637757

2010

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 PosttranslationalModification BEFREE Methylation of the p16 gene is frequently detected in lymphatic-invasive gastric cancer. 20683001

2010

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 PosttranslationalModification BEFREE We aimed to evaluate the inactivation of COX-2, HMLH1 and CDKN2A by promoter methylation and its relationship with the infection by different Helicobacter pylori strains in gastric cancer. 21849808

2011

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 Biomarker BEFREE Evaluating LINE-1, TP53 and p16 jointly yielded a more pronounced negative association with gastric cancer (OR: 0.24; 95% CI: 0.09-0.66).Age was a significant effect modifier. 22126203

2011