Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 6528
Gene Symbol: SLC5A5
SLC5A5
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.400 AlteredExpression BEFREE All-trans-retinoic acid (tRA) markedly induces NIS activity in some breast cancer cell lines and promotes uptake of β-emitting radioiodide (131)I sufficient for targeted cytotoxicity. 22157753

2012

Entrez Id: 6528
Gene Symbol: SLC5A5
SLC5A5
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.400 AlteredExpression BEFREE Altogether, these findings indicate that NIS expression is prevalent in breast cancer brain metastases and could have a therapeutic role via the delivery of radioactive iodide and selective ablation of tumor cells. 19618116

2010

Entrez Id: 6528
Gene Symbol: SLC5A5
SLC5A5
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.400 AlteredExpression BEFREE Basal NIS gene expression is detected in about 80% breast cancer specimens, but the fraction with functional iodide transport is relatively low. 16954431

2006

Entrez Id: 6528
Gene Symbol: SLC5A5
SLC5A5
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.400 AlteredExpression BEFREE Functional NIS expression in extrathyroidal tumors has been reported mainly in breast cancer. 19569179

2009

Entrez Id: 6528
Gene Symbol: SLC5A5
SLC5A5
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.400 Biomarker BEFREE Human breast cancer MDA-MB-231 cells transfected with the hNIS gene were injected subcutaneously into the right flanks of BALB/c nude mice. 22003972

2011

Entrez Id: 6528
Gene Symbol: SLC5A5
SLC5A5
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.400 AlteredExpression BEFREE In this study, using breast cancer cell lines, we established that tRA-responsive NIS expression is confined to estrogen receptor-alpha (ERalpha) positive cells and we investigated the role of ERalpha in the regulation of NIS expression. 16730657

2006

Entrez Id: 6528
Gene Symbol: SLC5A5
SLC5A5
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.400 AlteredExpression BEFREE In this study, we analyzed the regulation of NIS expression and function in the MCF-7 human breast cancer cell line. 15623812

2005

Entrez Id: 6528
Gene Symbol: SLC5A5
SLC5A5
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.400 AlteredExpression BEFREE In this study, we analyzed the regulation of the NIS and lactoperoxidase (LPO) gene expression in 4 different human breast cancer cell lines, representative of different histotypes of breast cancer. 19794300

2010

Entrez Id: 6528
Gene Symbol: SLC5A5
SLC5A5
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.400 AlteredExpression BEFREE In this study, we investigated the effect of an ER agonist (17β-estradiol, E(2)) or antagonist [trans-hydroxytamoxifen (TOT) or raloxifene (RAL)] treatment on the regulation of NIS gene expression and iodide uptake in an ERα-positive breast cancer (MCF-7) model. 21315285

2011

Entrez Id: 6528
Gene Symbol: SLC5A5
SLC5A5
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.400 Biomarker BEFREE In this study, we used superparamagentic iron oxide (SPIO)-labeled APCs to carry the human sodium iodide symporter (hNIS) gene to the sites of implanted breast cancer in mouse model. 19327159

2009

Entrez Id: 6528
Gene Symbol: SLC5A5
SLC5A5
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.400 AlteredExpression BEFREE In vivo radioiodide imaging and treatment of breast cancer xenografts after MUC1-driven expression of the sodium iodide symporter. 15746050

2005

Entrez Id: 6528
Gene Symbol: SLC5A5
SLC5A5
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.400 GeneticVariation BEFREE Oncolytic MV-Edm derivatives are genetically engineered to express the human carcinoembryonic antigen (MV-CEA virus) or the human sodium iodide symporter (MV-NIS virus) and are currently being tested in clinical trials against ovarian cancer, glioblastoma multiforme, multiple myeloma, mesothelioma, head and neck cancer, breast cancer and malignant peripheral nerve sheath tumors. 28228086

2018

Entrez Id: 6528
Gene Symbol: SLC5A5
SLC5A5
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.400 AlteredExpression BEFREE One is based on the reinduction of endogenous NIS expression in thyroid and breast cancer by targeting the main mechanisms involving tumoral transformation and dedifferentiation. 16990649

2006

Entrez Id: 6528
Gene Symbol: SLC5A5
SLC5A5
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.400 AlteredExpression BEFREE One of the most exciting current areas of NIS research-radioiodide treatment of extrathyroidal cancers-was launched by the discovery of functional expression of endogenous NIS in breast cancer and by the ectopic transfer of the NIS gene into otherwise non NIS-expressing cancers. 15062574

2003

Entrez Id: 6528
Gene Symbol: SLC5A5
SLC5A5
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.400 Biomarker BEFREE Our results indicate that improved efficiency of NIS gene therapy or reporter imaging in breast cancer may be possible with retinoic acid treatment. 17332617

2007

Entrez Id: 6528
Gene Symbol: SLC5A5
SLC5A5
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.400 AlteredExpression BEFREE Overexpression of wild-type p53 as a transgene or pharmacological activation by doxorubicin drug treatment shows significant suppression of NIS transcription in multiple BC cell types which also results in lowered NIS protein content and cellular iodide intake. 28528452

2017

Entrez Id: 6528
Gene Symbol: SLC5A5
SLC5A5
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.400 AlteredExpression BEFREE Recently, we reported significant stimulation of all-trans retinoic acid (atRA)-induced NIS expression in the estrogen-receptor positive human breast cancer cell line MCF-7 by dexamethasone (Dex) in vitro and in vivo, which might offer the potential to image and treat breast cancer with radioiodine. 20300827

2011

Entrez Id: 6528
Gene Symbol: SLC5A5
SLC5A5
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.400 AlteredExpression BEFREE Retinoic acid induces sodium/iodide symporter gene expression and radioiodide uptake in the MCF-7 breast cancer cell line. 10890895

2000

Entrez Id: 6528
Gene Symbol: SLC5A5
SLC5A5
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.400 AlteredExpression BEFREE Since NIS expression in breast cancer is not sufficient for a significant iodide uptake, drugs able to induce its expression and correct function are under evaluation. 20213084

2010

Entrez Id: 6528
Gene Symbol: SLC5A5
SLC5A5
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.400 Biomarker BEFREE T47D human breast cancer and PC-12 rat pheochromocytoma cells were transduced with the human NIS genes via an adenoviral vector. 18997042

2008

Entrez Id: 6528
Gene Symbol: SLC5A5
SLC5A5
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.400 AlteredExpression BEFREE The sodium iodide symporter (NIS) mediates active transport of iodide into the thyroid and the lactating mammary glands and is highly expressed in thyroid and breast carcinomas. 24708099

2014

Entrez Id: 6528
Gene Symbol: SLC5A5
SLC5A5
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.400 AlteredExpression BEFREE The goal of this study was to evaluate if the recently introduced PET radiotracer [<sup>18</sup>F]tetrafluoroborate ([<sup>18</sup>F]BF<sub>4</sub><sup>-</sup>) is useful for sensitive and specific metastasis detection in an orthotopic xenograft breast cancer model expressing the human sodium iodide symporter (NIS) as a reporter. 28424464

2017

Entrez Id: 6528
Gene Symbol: SLC5A5
SLC5A5
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.400 Biomarker BEFREE The preincubation of NIS-CHO with IgGs purified from sera of BC with the highest levels of TPOAb and TgAb caused an inhibition of iodine uptake of no more than 5%. 15648551

2004

Entrez Id: 6528
Gene Symbol: SLC5A5
SLC5A5
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.400 Therapeutic CTD_human The rat sodium iodide symporter gene permits more effective radioisotope concentration than the human sodium iodide symporter gene in human and rodent cancer cells. 12489024

2003

Entrez Id: 6528
Gene Symbol: SLC5A5
SLC5A5
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.400 Biomarker BEFREE The recent discovery that more than 80% of human breast carcinomas endogenously express NIS protein has opened a very interesting new area of research into the possibility of using radioiodide in the diagnosis and treatment of breast cancer. 14870777

2004