Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5291
Gene Symbol: PIK3CB
PIK3CB
CUI: C0700095
Disease: Central neuroblastoma
Central neuroblastoma
0.100 AlteredExpression BEFREE PI3K-mTORC2 but not PI3K-mTORC1 regulates transcription of HIF2A/EPAS1 and vascularization in neuroblastoma. 26432405

2015

Entrez Id: 5291
Gene Symbol: PIK3CB
PIK3CB
CUI: C0700095
Disease: Central neuroblastoma
Central neuroblastoma
0.100 Biomarker BEFREE A phase I/Ib trial targeting the Pi3k/Akt pathway using perifosine: Long-term progression-free survival of patients with resistant neuroblastoma. 27649927

2017

Entrez Id: 5291
Gene Symbol: PIK3CB
PIK3CB
CUI: C0700095
Disease: Central neuroblastoma
Central neuroblastoma
0.100 AlteredExpression BEFREE Activating mutations of the NRAS (neuroblastoma rat sarcoma viral oncogene) protein kinase, present in many cancers, induce a constitutive activation of both the RAS-RAF-MEK-ERK mitogen-activated protein kinase (MAPK) signal transduction pathway and the PI(3)K-AKT-mTOR, pathway. 27533468

2016

Entrez Id: 5291
Gene Symbol: PIK3CB
PIK3CB
CUI: C0700095
Disease: Central neuroblastoma
Central neuroblastoma
0.100 AlteredExpression BEFREE Activation of PI3K/Akt/mTOR signaling pathway correlates with oncogenesis, poor prognosis and chemotherapy resistance in NB. 29499203

2018

Entrez Id: 5291
Gene Symbol: PIK3CB
PIK3CB
CUI: C0700095
Disease: Central neuroblastoma
Central neuroblastoma
0.100 Biomarker BEFREE Anti-tumor effects of PIM/PI3K/mTOR triple kinase inhibitor IBL-302 in neuroblastoma. 31310053

2019

Entrez Id: 5291
Gene Symbol: PIK3CB
PIK3CB
CUI: C0700095
Disease: Central neuroblastoma
Central neuroblastoma
0.100 Biomarker BEFREE Autophagy markers were also measured in cypermethrin-treated neuroblastoma cells in the presence of 3-methyl adenine, a phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K) class III inhibitor; vinblastine, an autophagosome elongation inhibitor; bafilomycin A1, an autophagolysosome and lysosome fusion/abnormal acidification inhibitor or torin 1, a mechanistic target of rapamycin inhibitor. 28840510

2018

Entrez Id: 5291
Gene Symbol: PIK3CB
PIK3CB
CUI: C0700095
Disease: Central neuroblastoma
Central neuroblastoma
0.100 Biomarker BEFREE Both MAPK and PI3K pathways were involved in BDNF protection of NB cells from paclitaxel-induced cell death, while PI3K predominantly mediated BDNF protection of NB cells from etoposide or cisplatin-induced cell death. 16778834

2007

Entrez Id: 5291
Gene Symbol: PIK3CB
PIK3CB
CUI: C0700095
Disease: Central neuroblastoma
Central neuroblastoma
0.100 Biomarker BEFREE Consistent with these observations, PI3K inhibition in MYCN-amplified human neuroblastoma cell lines resulted in decreased levels of Mycn protein without affecting levels of MYCN mRNA and caused decreased proliferation and increased apoptosis. 16912192

2006

Entrez Id: 5291
Gene Symbol: PIK3CB
PIK3CB
CUI: C0700095
Disease: Central neuroblastoma
Central neuroblastoma
0.100 Biomarker BEFREE Evaluation of the expression of these PI3K genes can predict aggressive disease, and indicates stage-dependent involvement of PI3K-pathway members in neuroblastoma. 23232578

2013

Entrez Id: 5291
Gene Symbol: PIK3CB
PIK3CB
CUI: C0700095
Disease: Central neuroblastoma
Central neuroblastoma
0.100 AlteredExpression BEFREE Here we demonstrate that PI3K/Akt pathway is crucial for the upregulation of P2X7R expression in serum-deprived neuroblastoma cells, circumstance that facilitates cell proliferation in the absence of trophic support. 26687764

2015

Entrez Id: 5291
Gene Symbol: PIK3CB
PIK3CB
CUI: C0700095
Disease: Central neuroblastoma
Central neuroblastoma
0.100 AlteredExpression BEFREE Here, we show that p37δ, a kinase-dead isoform of the PI3K catalytic subunit p110δ, is over-expressed in neuroblastoma tumors, and that it correlates with the activation of both PI3K/Akt- and RAS-signaling pathways. 24026661

2013

Entrez Id: 5291
Gene Symbol: PIK3CB
PIK3CB
CUI: C0700095
Disease: Central neuroblastoma
Central neuroblastoma
0.100 Biomarker BEFREE However, NVP-BEZ235, a potent dual PI3K and mTOR inhibitor have not shown beneficial effects on neuroblastoma especially in terms of apoptosis induction as a single agent. 27278249

2016

Entrez Id: 5291
Gene Symbol: PIK3CB
PIK3CB
CUI: C0700095
Disease: Central neuroblastoma
Central neuroblastoma
0.100 Biomarker BEFREE In summary, cell proliferation via the GFRA2-PTEN-PI3K/AKT axis may represent new target to develop treatments for neuroblastoma. 30722993

2019

Entrez Id: 5291
Gene Symbol: PIK3CB
PIK3CB
CUI: C0700095
Disease: Central neuroblastoma
Central neuroblastoma
0.100 Biomarker BEFREE In summary, we found NLGN3 promoted neuroblastoma cell proliferation and growth through activating PI3K/AKT pathway and providing a new target for neuroblastoma therapy. 31150649

2019

Entrez Id: 5291
Gene Symbol: PIK3CB
PIK3CB
CUI: C0700095
Disease: Central neuroblastoma
Central neuroblastoma
0.100 Biomarker BEFREE In this study we investigated the phosphorylation status of key proteins in the PI3K/AKT/mTOR pathway and the effects of the mTOR inhibitors rapamycin and CCI-779 on neuroblastoma tumorigenesis. 18026138

2008

Entrez Id: 5291
Gene Symbol: PIK3CB
PIK3CB
CUI: C0700095
Disease: Central neuroblastoma
Central neuroblastoma
0.100 Biomarker BEFREE Inhibition of the PI3K/Akt pathway does not increase the sensitivity of neuroblastoma cell lines to TRAIL-induced apoptosis. 16769337

2006

Entrez Id: 5291
Gene Symbol: PIK3CB
PIK3CB
CUI: C0700095
Disease: Central neuroblastoma
Central neuroblastoma
0.100 Biomarker BEFREE Molecular rationale for the use of PI3K/AKT/mTOR pathway inhibitors in combination with crizotinib in ALK-mutated neuroblastoma. 25228590

2014

Entrez Id: 5291
Gene Symbol: PIK3CB
PIK3CB
CUI: C0700095
Disease: Central neuroblastoma
Central neuroblastoma
0.100 Biomarker BEFREE Moreover, inhibitors of PI3K/mTOR and GLI signaling reduced neuroblastoma cell growth, but no additional growth inhibitory effects were detected when the two classes of drugs were combined. 25134527

2014

Entrez Id: 5291
Gene Symbol: PIK3CB
PIK3CB
CUI: C0700095
Disease: Central neuroblastoma
Central neuroblastoma
0.100 Biomarker BEFREE Neuroprotection of miR-214 against isoflurane-induced neurotoxicity involves the PTEN/PI3K/Akt pathway in human neuroblastoma cell line SH-SY5Y. 31704096

2019

Entrez Id: 5291
Gene Symbol: PIK3CB
PIK3CB
CUI: C0700095
Disease: Central neuroblastoma
Central neuroblastoma
0.100 Biomarker BEFREE Our data also suggest that the phosphoinositide 3-kinase (PI3K) inhibitors may provide new opportunities for the treatment of the <i>MYCN</i>-amplified neuroblastoma subtype. 29137381

2017

Entrez Id: 5291
Gene Symbol: PIK3CB
PIK3CB
CUI: C0700095
Disease: Central neuroblastoma
Central neuroblastoma
0.100 Biomarker BEFREE Our previous studies have demonstrated that PI3K/AKT signaling is critical for the oncogenic transformations induced by gastrin-releasing peptide (GRP) and its receptor, GRP-R, in neuroblastoma. 23468863

2013

Entrez Id: 5291
Gene Symbol: PIK3CB
PIK3CB
CUI: C0700095
Disease: Central neuroblastoma
Central neuroblastoma
0.100 Biomarker BEFREE Palmitic acid stimulates energy metabolism and inhibits insulin/PI3K/AKT signaling in differentiated human neuroblastoma cells: The role of mTOR activation and mitochondrial ROS production. 28919254

2017

Entrez Id: 5291
Gene Symbol: PIK3CB
PIK3CB
CUI: C0700095
Disease: Central neuroblastoma
Central neuroblastoma
0.100 Biomarker BEFREE Pharmacological inhibition of PI3K greatly reduced the ability of PDGF-BB to block gp120 IIIB-mediated apoptosis and cell death in human neuroblastoma cells. 18973553

2008

Entrez Id: 5291
Gene Symbol: PIK3CB
PIK3CB
CUI: C0700095
Disease: Central neuroblastoma
Central neuroblastoma
0.100 Biomarker BEFREE PI103 combined doxorubicin significantly inhibits the growth of established NB tumors, induced apoptosis of tumor cells, and improved the survival of mice in vivo Taken together, our findings suggest that PI3K inhibition seems to be a promising option to sensitize tumor cells for chemotherapy in NB, which may be effective in the treatment of NBs. 26224681

2016

Entrez Id: 5291
Gene Symbol: PIK3CB
PIK3CB
CUI: C0700095
Disease: Central neuroblastoma
Central neuroblastoma
0.100 Biomarker BEFREE Polo-like kinase 4 mediates epithelial-mesenchymal transition in neuroblastoma via PI3K/Akt signaling pathway. 29352113

2018