Source: ALL

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4609
Gene Symbol: MYC
MYC
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.600 CausalMutation CGI

Entrez Id: 4609
Gene Symbol: MYC
MYC
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.600 GeneticVariation BEFREE "Triple hit" lymphomas: A retrospective cytology case series of an uncommon high grade B-cell malignancy with C-MYC, BCL-2 and BCL-6 rearrangements. 30043475

2018
Entrez Id: 4609
Gene Symbol: MYC
MYC
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.600 GeneticVariation BEFREE Cancer risk-associated single-nucleotide polymorphisms (SNPs) contain more potent enhancer activity, promoting higher MYC levels and a greater risk of disease. 24985129

2014
Entrez Id: 4609
Gene Symbol: MYC
MYC
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.600 Biomarker BEFREE Cancer patient data were used to verify the correlation between drug response and MYC and/or TYMS mRNA levels. 31648989

2019
Entrez Id: 4609
Gene Symbol: MYC
MYC
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.600 Biomarker BEFREE MYC amplification was almost 3 times more frequent in medullary cancer (15.9%), than in the histologic subtype with the second highest frequency (ductal; 5.6%; P = 0.0046). 15574759

2004
Entrez Id: 4609
Gene Symbol: MYC
MYC
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.600 Biomarker BEFREE MYC and 13 genes of the other four regions with putative relevance to cancer were selected. 16130124

2005
Entrez Id: 4609
Gene Symbol: MYC
MYC
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.600 Biomarker BEFREE MYC is thought to induce cancer through an exaggerated effect on these physiologic programs. 18535662

2008
Entrez Id: 4609
Gene Symbol: MYC
MYC
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.600 Biomarker BEFREE c-myc protein product is a marker of DNA synthesis but not of malignancy in human gastrointestinal tissues and tumours. 1933191

1991
Entrez Id: 4609
Gene Symbol: MYC
MYC
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.600 Biomarker BEFREE MYC oncogene is frequently deregulated in human cancer, often associated with tumor progression. 21460180

2011
Entrez Id: 4609
Gene Symbol: MYC
MYC
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.600 Biomarker BEFREE MYC has been widely presumed as the regulated target gene, but definitive evidence functionally linking these cancer regions with MYC has been difficult to obtain. 21814516

2011
Entrez Id: 4609
Gene Symbol: MYC
MYC
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.600 Biomarker BEFREE MYC on the path to cancer. 22464321

2012
Entrez Id: 4609
Gene Symbol: MYC
MYC
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.600 Biomarker BEFREE MYC suppresses cancer metastasis by direct transcriptional silencing of αv and β3 integrin subunits. 22581054

2012
Entrez Id: 4609
Gene Symbol: MYC
MYC
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.600 AlteredExpression BEFREE MYC (c-Myc) is a transcription factor frequently deregulated in human cancer. 22710719

2013
Entrez Id: 4609
Gene Symbol: MYC
MYC
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.600 Biomarker BEFREE MYC (c-Myc) deregulation has been frequently associated with aggressive lymphomas and adverse clinical outcome in B-cell malignancies. 24394940

2014
Entrez Id: 4609
Gene Symbol: MYC
MYC
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.600 AlteredExpression BEFREE MYC expression was not able to statistically distinguish cancer from CIN (P = 0.393). 24662128

2014
Entrez Id: 4609
Gene Symbol: MYC
MYC
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.600 Biomarker BEFREE MYC activation is a hallmark of cancer initiation and maintenance. 24890832

2014
Entrez Id: 4609
Gene Symbol: MYC
MYC
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.600 AlteredExpression BEFREE MYC expression is tightly correlated with cell-cycle progression in normal tissues, whereas unchecked MYC expression is among the most prominent hallmarks of the hyperproliferation associated with most forms of cancer. 24985130

2014
Entrez Id: 4609
Gene Symbol: MYC
MYC
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.600 Biomarker BEFREE MYC and NOTCH1 contribute to the pathogenesis of lymphoid malignancies. 25311243

2015
Entrez Id: 4609
Gene Symbol: MYC
MYC
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.600 Biomarker BEFREE MYC family members are among the most frequently deregulated oncogenes in human cancers, yet direct therapeutic targeting of MYC in cancer has been challenging thus far. 25495526

2014
Entrez Id: 4609
Gene Symbol: MYC
MYC
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.600 AlteredExpression BEFREE MYC is an oncoprotein transcription factor that is overexpressed in the majority of malignancies. 25818646

2015
Entrez Id: 4609
Gene Symbol: MYC
MYC
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.600 AlteredExpression BEFREE MYC proteins are overexpressed or deregulated in a majority of malignancies and drive tumorigenesis by inducing widespread transcriptional reprogramming that promotes cell proliferation, metabolism, and genomic instability. 26383167

2015
Entrez Id: 4609
Gene Symbol: MYC
MYC
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.600 Biomarker BEFREE MYC translocation-negative Burkitt lymphoma, similarly to other aggressive B-cell non Hodgkin's lymphomas, may represent a model to understand the intricate molecular pathway responsible for MYC dysregulation in cancer. 26453442

2015
Entrez Id: 4609
Gene Symbol: MYC
MYC
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.600 PosttranslationalModification BEFREE MYC enhances mRNA cap methylation above and beyond transcriptional induction.Mol Cancer Res; 15(2); 213-24.©2016 AACR. 27899423

2017
Entrez Id: 4609
Gene Symbol: MYC
MYC
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.600 Biomarker BEFREE MYC family proteins play fundamental roles in stem and progenitor cell homeostasis, morphogenesis and cancer. 28230739

2017
Entrez Id: 4609
Gene Symbol: MYC
MYC
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.600 Biomarker BEFREE MYC and RAF: Key Effectors in Cellular Signaling and Major Drivers in Human Cancer. 28466200

2019