|
| Entrez Id: |
7157 |
| Gene Symbol: |
TP53 |
TP53
|
Li-Fraumeni Syndrome
|
1.000 |
CausalMutation |
CLINVAR |
"Apparently ""BRCA-related"" breast and ovarian cancer patient with germline TP53 mutation."
|
21535297 |
2011 |
|
| Entrez Id: |
7157 |
| Gene Symbol: |
TP53 |
TP53
|
Li-Fraumeni Syndrome
|
1.000 |
GeneticVariation |
CLINVAR |
"Apparently ""BRCA-related"" breast and ovarian cancer patient with germline TP53 mutation."
|
21535297 |
2011 |
|
| Entrez Id: |
7157 |
| Gene Symbol: |
TP53 |
TP53
|
Li-Fraumeni Syndrome
|
1.000 |
CausalMutation |
CLINVAR |
A common gain of function of p53 cancer mutants in inducing genetic instability.
|
19881536 |
2010 |
|
| Entrez Id: |
7157 |
| Gene Symbol: |
TP53 |
TP53
|
Li-Fraumeni Syndrome
|
1.000 |
CausalMutation |
CLINVAR |
A common p53 mutation (R175H) activates c-Met receptor tyrosine kinase to enhance tumor cell invasion.
|
23792586 |
2013 |
|
| Entrez Id: |
7157 |
| Gene Symbol: |
TP53 |
TP53
|
Li-Fraumeni Syndrome
|
1.000 |
CausalMutation |
CLINVAR |
A comprehensive study of TP53 mutations in chronic lymphocytic leukemia: Analysis of 1287 diagnostic and 1148 follow-up CLL samples.
|
21232794 |
2011 |
|
| Entrez Id: |
7157 |
| Gene Symbol: |
TP53 |
TP53
|
Li-Fraumeni Syndrome
|
1.000 |
GeneticVariation |
CLINVAR |
A comprehensive study of TP53 mutations in chronic lymphocytic leukemia: Analysis of 1287 diagnostic and 1148 follow-up CLL samples.
|
21232794 |
2011 |
|
| Entrez Id: |
7157 |
| Gene Symbol: |
TP53 |
TP53
|
Li-Fraumeni Syndrome
|
1.000 |
GeneticVariation |
CLINVAR |
A de novo p53 germline mutation affecting codon 151 in a six year old child with multiple tumors.
|
7881428 |
1994 |
|
| Entrez Id: |
7157 |
| Gene Symbol: |
TP53 |
TP53
|
Li-Fraumeni Syndrome
|
1.000 |
CausalMutation |
CLINVAR |
A de novo p53 germline mutation affecting codon 151 in a six year old child with multiple tumors.
|
7881428 |
1994 |
|
| Entrez Id: |
7157 |
| Gene Symbol: |
TP53 |
TP53
|
Li-Fraumeni Syndrome
|
1.000 |
CausalMutation |
CLINVAR |
A detailed study of loss of heterozygosity on chromosome 17 in tumours from Li-Fraumeni patients carrying a mutation to the TP53 gene.
|
9047394 |
1997 |
|
| Entrez Id: |
7157 |
| Gene Symbol: |
TP53 |
TP53
|
Li-Fraumeni Syndrome
|
1.000 |
CausalMutation |
CLINVAR |
A global suppressor motif for p53 cancer mutants.
|
15037740 |
2004 |
|
| Entrez Id: |
7157 |
| Gene Symbol: |
TP53 |
TP53
|
Li-Fraumeni Syndrome
|
1.000 |
CausalMutation |
CLINVAR |
A Japanese patient with Li-Fraumeni syndrome who had nine primary malignancies associated with a germline mutation of the p53 tumor-suppressor gene.
|
18307025 |
2008 |
|
| Entrez Id: |
7157 |
| Gene Symbol: |
TP53 |
TP53
|
Li-Fraumeni Syndrome
|
1.000 |
CausalMutation |
CLINVAR |
A Li-Fraumeni syndrome family with retained heterozygosity for a germline TP53 mutation in two tumors.
|
12885464 |
2003 |
|
| Entrez Id: |
7157 |
| Gene Symbol: |
TP53 |
TP53
|
Li-Fraumeni Syndrome
|
1.000 |
CausalMutation |
CLINVAR |
A novel HER2-positive breast cancer phenotype arising from germline TP53 mutations.
|
20805372 |
2010 |
|
| Entrez Id: |
7157 |
| Gene Symbol: |
TP53 |
TP53
|
Li-Fraumeni Syndrome
|
1.000 |
CausalMutation |
CLINVAR |
A novel p53 mutant retained functional activity in lung carcinomas.
|
12509279 |
2002 |
|
| Entrez Id: |
7157 |
| Gene Symbol: |
TP53 |
TP53
|
Li-Fraumeni Syndrome
|
1.000 |
GeneticVariation |
CLINVAR |
A previously undescribed mutation within the tetramerisation domain of TP53 in a family with Li-Fraumeni syndrome.
|
8649785 |
1996 |
|
| Entrez Id: |
7157 |
| Gene Symbol: |
TP53 |
TP53
|
Li-Fraumeni Syndrome
|
1.000 |
CausalMutation |
CLINVAR |
A prognostic signature of defective p53-dependent G1 checkpoint function in melanoma cell lines.
|
22540896 |
2012 |
|
| Entrez Id: |
7157 |
| Gene Symbol: |
TP53 |
TP53
|
Li-Fraumeni Syndrome
|
1.000 |
CausalMutation |
CLINVAR |
A simple p53 functional assay for screening cell lines, blood, and tumors.
|
7732013 |
1995 |
|
| Entrez Id: |
7157 |
| Gene Symbol: |
TP53 |
TP53
|
Li-Fraumeni Syndrome
|
1.000 |
GeneticVariation |
CLINVAR |
A transforming p53 mutant, which binds DNA, transactivates and induces apoptosis reveals a nuclear:cytoplasmic shuttling defect.
|
9525742 |
1998 |
|
| Entrez Id: |
7157 |
| Gene Symbol: |
TP53 |
TP53
|
Li-Fraumeni Syndrome
|
1.000 |
CausalMutation |
CLINVAR |
A young woman with bilateral breast cancer: identifying a genetic cause and implications for management.
|
23667202 |
2013 |
|
| Entrez Id: |
7157 |
| Gene Symbol: |
TP53 |
TP53
|
Li-Fraumeni Syndrome
|
1.000 |
CausalMutation |
CLINVAR |
Abrogation of wild-type p53-mediated transactivation is insufficient for mutant p53-induced immortalization of normal human mammary epithelial cells.
|
9407971 |
1997 |
|
| Entrez Id: |
7157 |
| Gene Symbol: |
TP53 |
TP53
|
Li-Fraumeni Syndrome
|
1.000 |
CausalMutation |
CLINVAR |
Absence of germline p16(INK4a) alterations in p53 wild type Li-Fraumeni syndrome families.
|
10922393 |
2000 |
|
| Entrez Id: |
7157 |
| Gene Symbol: |
TP53 |
TP53
|
Li-Fraumeni Syndrome
|
1.000 |
GeneticVariation |
CLINVAR |
Absence of germline p16(INK4a) alterations in p53 wild type Li-Fraumeni syndrome families.
|
10922393 |
2000 |
|
| Entrez Id: |
7157 |
| Gene Symbol: |
TP53 |
TP53
|
Li-Fraumeni Syndrome
|
1.000 |
CausalMutation |
CLINVAR |
Acute myeloid leukemia with TP53 germ line mutations.
|
27621308 |
2016 |
|
| Entrez Id: |
7157 |
| Gene Symbol: |
TP53 |
TP53
|
Li-Fraumeni Syndrome
|
1.000 |
GeneticVariation |
CLINVAR |
Alteration of p53 gene in ovarian carcinoma: clinicopathological correlation and prognostic significance.
|
7981076 |
1994 |
|
| Entrez Id: |
7157 |
| Gene Symbol: |
TP53 |
TP53
|
Li-Fraumeni Syndrome
|
1.000 |
CausalMutation |
CLINVAR |
Altered-function p53 missense mutations identified in breast cancers can have subtle effects on transactivation.
|
20407015 |
2010 |