Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7097
Gene Symbol: TLR2
TLR2
CUI: C0023343
Disease: Leprosy
Leprosy
0.380 Biomarker CTD_human

Entrez Id: 7096
Gene Symbol: TLR1
TLR1
CUI: C0023343
Disease: Leprosy
Leprosy
0.370 Biomarker CTD_human

Entrez Id: 3105
Gene Symbol: HLA-A
HLA-A
CUI: C0023343
Disease: Leprosy
Leprosy
0.030 GeneticVariation BEFREE HLA-A and -B locus antigens were determined in 170 unrelated patients with leprosy and 100 healthy controls. 87028

1979

Entrez Id: 590
Gene Symbol: BCHE
BCHE
CUI: C0023343
Disease: Leprosy
Leprosy
0.010 Biomarker BEFREE Serum atypical pseudocholinesterase and leprosy. 528104

1979

Entrez Id: 6277
Gene Symbol: S100A6
S100A6
CUI: C0023343
Disease: Leprosy
Leprosy
0.020 Biomarker BEFREE In order to better understand the role of Mycobacterium leprae nasal carriage in the maintenance of infection reservoirs and transmission of leprosy, we applied a polymerase chain reaction (PCR) that detected a 531-bp fragment of the pra gene of M. leprae on nasal swab specimens collected through a total population survey from individuals living in an area in which leprosy is endemic. 8263180

1993

Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1
CUI: C0023343
Disease: Leprosy
Leprosy
0.190 Biomarker BEFREE The much stronger association of DRB1*1501 with the multibacillary form than with the TT type of leprosy suggests a possible role in the differential immune response to M. leprae antigens. 8284786

1993

Entrez Id: 129831
Gene Symbol: RBM45
RBM45
CUI: C0023343
Disease: Leprosy
Leprosy
0.050 Biomarker BEFREE The much stronger association of DRB1*1501 with the multibacillary form than with the TT type of leprosy suggests a possible role in the differential immune response to M. leprae antigens. 8284786

1993

Entrez Id: 3117
Gene Symbol: HLA-DQA1
HLA-DQA1
CUI: C0023343
Disease: Leprosy
Leprosy
0.030 Biomarker BEFREE On the other hand, DRB1*0701, DQB1*0201 and DQA1*0201 were decreased in the multibacillary leprosy patients (MLP) compared to TT patients and controls, and DQB1*0503 was selectively decreased in TT patients, suggesting that these HLA alleles might play a role in modulating the immune response that determines the form of leprosy that develops in each patient. 8284786

1993

Entrez Id: 348
Gene Symbol: APOE
APOE
CUI: C0023343
Disease: Leprosy
Leprosy
0.020 GeneticVariation BEFREE The allelic frequencies of the apo E gene did not differ between demented patients with leprosy and controls. 8728486

1996

Entrez Id: 51251
Gene Symbol: NT5C3A
NT5C3A
CUI: C0023343
Disease: Leprosy
Leprosy
0.010 Biomarker BEFREE All seven sarcoidosis, four of six tuberculosis, and all six leprosy patient serum specimens showed strong reactivity with p36 antigen. 8862592

1996

Entrez Id: 100289545
Gene Symbol: H3C9P
H3C9P
CUI: C0023343
Disease: Leprosy
Leprosy
0.010 Biomarker BEFREE All seven sarcoidosis, four of six tuberculosis, and all six leprosy patient serum specimens showed strong reactivity with p36 antigen. 8862592

1996

Entrez Id: 302
Gene Symbol: ANXA2
ANXA2
CUI: C0023343
Disease: Leprosy
Leprosy
0.010 Biomarker BEFREE All seven sarcoidosis, four of six tuberculosis, and all six leprosy patient serum specimens showed strong reactivity with p36 antigen. 8862592

1996

Entrez Id: 4331
Gene Symbol: MNAT1
MNAT1
CUI: C0023343
Disease: Leprosy
Leprosy
0.010 Biomarker BEFREE All seven sarcoidosis, four of six tuberculosis, and all six leprosy patient serum specimens showed strong reactivity with p36 antigen. 8862592

1996

Entrez Id: 3329
Gene Symbol: HSPD1
HSPD1
CUI: C0023343
Disease: Leprosy
Leprosy
0.030 Biomarker BEFREE These Th2 inducer epitopes on HSP65 (DR1 restricted) and HSP18 (DR7 restricted) were absent from TDB65-2 and TDB18-3 which exclusively triggered Th1 cells in both TT and LL forms of leprosy in the context of multiple DR alleles, DR15 being the major antigen-presenting allele. 9000043

1997

Entrez Id: 1493
Gene Symbol: CTLA4
CTLA4
CUI: C0023343
Disease: Leprosy
Leprosy
0.020 Biomarker BEFREE The 104-bp allelomorph of CTLA4 was not observed in any of the 25 cases of leprosy. 9225967

1997

Entrez Id: 6556
Gene Symbol: SLC11A1
SLC11A1
CUI: C0023343
Disease: Leprosy
Leprosy
0.390 GeneticVariation BEFREE This finding is consistent with the hypothesis that NRAMP1 itself is a leprosy susceptibility locus. 9419180

1998

Entrez Id: 641455
Gene Symbol: POTEM
POTEM
CUI: C0023343
Disease: Leprosy
Leprosy
0.010 GeneticVariation BEFREE The allelic frequencies of the ACT gene did not differ even between demented patients with leprosy and age-matched controls. 9469262

1998

Entrez Id: 11332
Gene Symbol: ACOT7
ACOT7
CUI: C0023343
Disease: Leprosy
Leprosy
0.010 GeneticVariation BEFREE The allelic frequencies of the ACT gene did not differ even between demented patients with leprosy and age-matched controls. 9469262

1998

Entrez Id: 9457
Gene Symbol: FHL5
FHL5
CUI: C0023343
Disease: Leprosy
Leprosy
0.010 GeneticVariation BEFREE The allelic frequencies of the ACT gene did not differ even between demented patients with leprosy and age-matched controls. 9469262

1998

Entrez Id: 72
Gene Symbol: ACTG2
ACTG2
CUI: C0023343
Disease: Leprosy
Leprosy
0.010 GeneticVariation BEFREE The allelic frequencies of the ACT gene did not differ even between demented patients with leprosy and age-matched controls. 9469262

1998

Entrez Id: 71
Gene Symbol: ACTG1
ACTG1
CUI: C0023343
Disease: Leprosy
Leprosy
0.010 GeneticVariation BEFREE The allelic frequencies of the ACT gene did not differ even between demented patients with leprosy and age-matched controls. 9469262

1998

Entrez Id: 440915
Gene Symbol: POTEKP
POTEKP
CUI: C0023343
Disease: Leprosy
Leprosy
0.010 GeneticVariation BEFREE The allelic frequencies of the ACT gene did not differ even between demented patients with leprosy and age-matched controls. 9469262

1998

Entrez Id: 345651
Gene Symbol: ACTBL2
ACTBL2
CUI: C0023343
Disease: Leprosy
Leprosy
0.010 GeneticVariation BEFREE The allelic frequencies of the ACT gene did not differ even between demented patients with leprosy and age-matched controls. 9469262

1998

Entrez Id: 12
Gene Symbol: SERPINA3
SERPINA3
CUI: C0023343
Disease: Leprosy
Leprosy
0.010 GeneticVariation BEFREE The allelic frequencies of the ACT gene did not differ even between demented patients with leprosy and age-matched controls. 9469262

1998

Entrez Id: 6556
Gene Symbol: SLC11A1
SLC11A1
CUI: C0023343
Disease: Leprosy
Leprosy
0.390 GeneticVariation BEFREE Through comparative genomics, we have identified the homologous human NRAMP1 gene, alleles of which are now being used for tests of linkage with TB and leprosy. 9509263

1998