Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0007847
Disease: Malignant tumor of cervix
Malignant tumor of cervix
0.400 GeneticVariation BEFREE It may be assumed that the low incidence of cervical cancer in Israeli Jewish women and the differences between the ethnic groups may be related to the frequency pattern of the homozygous arginine p53 polymorphism 12445252

2003

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0007847
Disease: Malignant tumor of cervix
Malignant tumor of cervix
0.400 GeneticVariation BEFREE This study aims to investigate whether the genotype distribution of p53 codon 72 may be a risk factor for cervical cancer among Gabonese women. 25502079

2015

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0007847
Disease: Malignant tumor of cervix
Malignant tumor of cervix
0.400 GeneticVariation BEFREE Effect of p53 polymorphism on the susceptibility of cervical cancer. 11306909

2001

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0007847
Disease: Malignant tumor of cervix
Malignant tumor of cervix
0.400 GeneticVariation BEFREE In this study, undertaken at King Edward VIII Hospital, Durban, South Africa, we determined the p53 codon 72 status in 281 black South African women with cervical cancer and 340 ethnically matched healthy control subjects. 12144687

2002

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0007847
Disease: Malignant tumor of cervix
Malignant tumor of cervix
0.400 GeneticVariation BEFREE We found no increased risk of developing cervical cancer in respect to p53 polymorphism, independent of histological diagnosis. 11072671

2000

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0007847
Disease: Malignant tumor of cervix
Malignant tumor of cervix
0.400 Biomarker BEFREE Correlation between human papillomavirus-associated cervical cancer and p53 codon 72 arginine/proline polymorphism. 10647890

1999

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0007847
Disease: Malignant tumor of cervix
Malignant tumor of cervix
0.400 GeneticVariation BEFREE No relationship observed between human p53 codon-72 genotype and HPV-associated cervical cancer in a population group with a low arginine-72 allele frequency. 17504512

2007

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0007847
Disease: Malignant tumor of cervix
Malignant tumor of cervix
0.400 GeneticVariation BEFREE In additional, interaction between these p53 and p21 polymorphisms increased the risk of cervical cancer in a multiplicative manner, with the OR being 3.96 (95% CI, 1.51-10.41) for subjects carrying both p53 Arg/Arg and p21 Ser/Ser genotypes. 20732856

2010

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0007847
Disease: Malignant tumor of cervix
Malignant tumor of cervix
0.400 GeneticVariation BEFREE In the population studied, individuals homozygous for the arginine variant of codon 72 of the p53 gene were not at increased risk of cervical cancer. 9742979

1998

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0007847
Disease: Malignant tumor of cervix
Malignant tumor of cervix
0.400 AlteredExpression BEFREE The intratumoral delivery of exogenous E1A carried by SDION increases p53 expression but inhibits HER-2/neu expression, and enhances the radiosensitivity of human cervical cancer in xenograft mice. 20587666

2010

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0007847
Disease: Malignant tumor of cervix
Malignant tumor of cervix
0.400 GeneticVariation BEFREE Results from the current meta-analysis suggests that p53 codon 72 polymorphism might be associated with increased risk of cervical cancer, especially among Indians. 23244080

2012

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0007847
Disease: Malignant tumor of cervix
Malignant tumor of cervix
0.400 Biomarker BEFREE HPV16 abrogation of p53 binding to the IRF6 promoter was shown by ChIP in tissues from patients with cervical cancer. 30089163

2018

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0007847
Disease: Malignant tumor of cervix
Malignant tumor of cervix
0.400 AlteredExpression BEFREE This study evaluated the immunohistochemical (IHC) expression of p16, p53 and Ki-67 in precancerous lesions and in cervical cancer (CC). 28554769

2017

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0007847
Disease: Malignant tumor of cervix
Malignant tumor of cervix
0.400 GeneticVariation BEFREE An association between codon-72 p53 polymorphism and risk of human papillomavirus (HPV)-induced cervical cancer has been found recently, but it has been difficult to replicate. 10918193

2000

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0007847
Disease: Malignant tumor of cervix
Malignant tumor of cervix
0.400 AlteredExpression BEFREE Loss of miR-140/142/340/383 contributes to PD-L1 upregulation. miR-18a enhances PD-L1 levels by targeting PTEN, WNK2 (ERK1/2 pathway inhibitor), and SOX6 (Wnt/β-catenin pathway inhibitor and p53 pathway activator) to activate the PI3K/AKT, MEK/ERK, and Wnt/β-catenin pathways and inhibit the p53 pathway, and miR-18a also directly suppresses the expression of the tumor suppressors BTG3 and RBSP3 (CTDSPL). miR-18a overexpression in CC cells is triggered by OCT4 overexpression. 29855617

2018

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0007847
Disease: Malignant tumor of cervix
Malignant tumor of cervix
0.400 GeneticVariation BEFREE This suggests that, in p53 Arg/Arg women, infection with HPV-16 350T variants confers a higher risk of cervical cancer. 10644829

2000

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0007847
Disease: Malignant tumor of cervix
Malignant tumor of cervix
0.400 GeneticVariation BEFREE In the present work, the exon 4 sequence of TP53 gene in CC and healthy Mexican-mestizo women were analyzed. 20661667

2011

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0007847
Disease: Malignant tumor of cervix
Malignant tumor of cervix
0.400 Biomarker BEFREE Radiotherapy modulates expression of EGFR, ERCC1 and p53 in cervical cancer. 29160417

2017

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0007847
Disease: Malignant tumor of cervix
Malignant tumor of cervix
0.400 GeneticVariation BEFREE The Arg>Pro polymorphism in codon 72 of p53 gene is known to affect the susceptibility of cervical cancer differently in different population worldwide although information regarding its role in determining survival status and disease outcome in patients is lacking. 28139534

2016

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0007847
Disease: Malignant tumor of cervix
Malignant tumor of cervix
0.400 GeneticVariation BEFREE A. Storey et al.[Nature (Lond.), 393: 229-234, 1998)] reported a 7-fold increased risk of cervical cancer associated with having an Arg/Arg polymorphism at codon 72 of p53 compared with the Pro/Arg heterozygotes (odds ratio, 7.4; 95% confidence interval, 2.1-29.4). 10698487

2000

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0007847
Disease: Malignant tumor of cervix
Malignant tumor of cervix
0.400 GeneticVariation BEFREE We investigated a possible association between TP53 polymorphism and cervical cancer in a Peruvian population with high prevalence of HPV infection. 11535556

2001

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0007847
Disease: Malignant tumor of cervix
Malignant tumor of cervix
0.400 Biomarker BEFREE Here we report that differential regulation of pro- and anti-p53 setups not only upregulates p53 transcription but also stabilizes and activates p53 protein to ensure p53-induced apoptosis in HPV-18-infected cervical cancer. 21765464

2012

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0007847
Disease: Malignant tumor of cervix
Malignant tumor of cervix
0.400 GeneticVariation BEFREE The p53 codon 72 arginine allele showed a suggestive negative association with cervical cancer (HET, OR = 0.49; 95% CI, 0.14-1.63; homozygotes, OR = 0.35; 95% CI, 0.11-1.17). 12142377

2002

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0007847
Disease: Malignant tumor of cervix
Malignant tumor of cervix
0.400 GeneticVariation BEFREE The aim of this study was to elucidate the prevalence of HPV, especially HPV 16, in cervical cancer patients and in healthy women, to investigate the distribution of p53 gene 72 codon polymorphism and to correlate these to cervical cancer risk in Lithuanian women. 16488468

2006

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0007847
Disease: Malignant tumor of cervix
Malignant tumor of cervix
0.400 GeneticVariation BEFREE Some authors assert that the discrepancy in the results could not be attributed to differences in the methods; however, the Brazilian study emphasized the effect of inter-laboratory variation in detecting the association between p53 polymorphism and cervical cancer. 10830578

2000