Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0007847
Disease: Malignant tumor of cervix
Malignant tumor of cervix
0.400 CausalMutation CGI

Entrez Id: 2261
Gene Symbol: FGFR3
FGFR3
CUI: C0007847
Disease: Malignant tumor of cervix
Malignant tumor of cervix
0.340 CausalMutation CGI

Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0007847
Disease: Malignant tumor of cervix
Malignant tumor of cervix
0.340 CausalMutation CGI

Entrez Id: 3265
Gene Symbol: HRAS
HRAS
CUI: C0007847
Disease: Malignant tumor of cervix
Malignant tumor of cervix
0.320 CausalMutation CGI

Entrez Id: 64218
Gene Symbol: SEMA4A
SEMA4A
CUI: C0007847
Disease: Malignant tumor of cervix
Malignant tumor of cervix
0.010 AlteredExpression BEFREE To examine the correlations between ras oncogene expression and the development of cervical cancer, the authors studied the reactivity of cervical intraepithelial neoplasia (CIN) and microinvasive lesions of the human uterine cervix by using anti-ras p21 mouse monoclonal antibody rp35. 2196111

1990

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0007847
Disease: Malignant tumor of cervix
Malignant tumor of cervix
0.400 Biomarker BEFREE The inactivation of the wild-type p53 function resulting from a missense mutation, or the lack of detectable wild-type p53 protein due to the translational/post-translational deregulation of p53 protein levels may be the contributing factor in the tumorigenicity of these five cases of cervical cancer. 1322252

1992

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0007847
Disease: Malignant tumor of cervix
Malignant tumor of cervix
0.400 Biomarker BEFREE Our data indicate that loss of wild-type p53 function is important in the pathology of cervical cancer and that in the absence of an HPV-encoded gene product that mediates loss of p53 function, somatic mutation of the gene is required. 1349102

1992

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0007847
Disease: Malignant tumor of cervix
Malignant tumor of cervix
0.400 GeneticVariation BEFREE Although a high incidence of HPV DNA integration and a low incidence of p53 mutation were confirmed in cancer of the uterine cervix, there was no inverse association between integration of HPV types 16 and/or 18 DNA and p53 mutation. 1336492

1992

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0007847
Disease: Malignant tumor of cervix
Malignant tumor of cervix
0.400 GeneticVariation BEFREE It appears that p53 and Rb mutations are a very rare event in cervical cancer and their occurrence is apparently not strictly correlated with HPV status. 8384745

1993

Entrez Id: 4830
Gene Symbol: NME1
NME1
CUI: C0007847
Disease: Malignant tumor of cervix
Malignant tumor of cervix
0.020 AlteredExpression BEFREE A strong association has been observed between reduced expression of Nm23 gene and acquisition of metastatic behaviour in some tumour cells including breast cancer and melanoma, but not in others such as colon cancer, neuroblastoma, and cervical cancer. 8394105

1993

Entrez Id: 8190
Gene Symbol: MIA
MIA
CUI: C0007847
Disease: Malignant tumor of cervix
Malignant tumor of cervix
0.010 GeneticVariation BEFREE To elucidate the involvement of MK in the development of tumors, we further examined its expression in a variety of human neoplastic cell lines: YMB-1-C (breast cancer), EBC-1 (lung squamous cell carcinoma), RERF-LC-OK (lung adenocarcinoma), SBC-3 (lung small cell carcinoma), HSC-2 (mouth squamous cell carcinoma), NUGC-2 (gastric cancer), COLO201 (colon cancer), HepG2 (hepatoma), MIA PaCa-2 (pancreatic cancer), MCAS (ovarian cancer), HeLa (cervical cancer), BeWo (chorionic carcinoma), ITO-II (testicular tumor), T24 (urinary bladder tumor), and G-401 (Wilms' tumor). 8434639

1993

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0007847
Disease: Malignant tumor of cervix
Malignant tumor of cervix
0.400 Biomarker BEFREE Human papillomavirus DNA and p53 status in stage IB bulky cervical cancer. 7962045

1994

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0007847
Disease: Malignant tumor of cervix
Malignant tumor of cervix
0.400 AlteredExpression BEFREE In summary, although inactivation of p53 mediated either by E6 or by mutations may be an important key step in the development of cervical carcinoma, our study suggests that other mechanisms may also be involved in development of cervical cancer. 8302581

1994

Entrez Id: 3119
Gene Symbol: HLA-DQB1
HLA-DQB1
CUI: C0007847
Disease: Malignant tumor of cervix
Malignant tumor of cervix
0.100 GeneticVariation BEFREE Association between HLA-DQB1 alleles and risk for cervical cancer in African-American women. 8181853

1994

Entrez Id: 2944
Gene Symbol: GSTM1
GSTM1
CUI: C0007847
Disease: Malignant tumor of cervix
Malignant tumor of cervix
0.100 GeneticVariation BEFREE Progression of cervical intraepithelial neoplasia to cervical cancer: interactions of cytochrome P450 CYP2D6 EM and glutathione s-transferase GSTM1 null genotypes and cigarette smoking. 7917923

1994

Entrez Id: 27306
Gene Symbol: HPGDS
HPGDS
CUI: C0007847
Disease: Malignant tumor of cervix
Malignant tumor of cervix
0.080 GeneticVariation BEFREE Progression of cervical intraepithelial neoplasia to cervical cancer: interactions of cytochrome P450 CYP2D6 EM and glutathione s-transferase GSTM1 null genotypes and cigarette smoking. 7917923

1994

Entrez Id: 847
Gene Symbol: CAT
CAT
CUI: C0007847
Disease: Malignant tumor of cervix
Malignant tumor of cervix
0.030 AlteredExpression BEFREE CAT expression in cervical cancer-derived HT3, SiHa and CaSki cells appeared 5- to 6-fold increased under the control of the short LCR. 8137827

1994

Entrez Id: 144125
Gene Symbol: OR2AG1
OR2AG1
CUI: C0007847
Disease: Malignant tumor of cervix
Malignant tumor of cervix
0.010 AlteredExpression BEFREE CAT expression in cervical cancer-derived HT3, SiHa and CaSki cells appeared 5- to 6-fold increased under the control of the short LCR. 8137827

1994

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0007847
Disease: Malignant tumor of cervix
Malignant tumor of cervix
0.400 Biomarker BEFREE Because most HPV-positive cervical carcinoma cell lines contain wild-type p53 whereas HPV-negative cell lines have point mutations in the p53 gene, a major role in the development of HPV-negative cervical cancer has been attributed to p53. 8630877

1995

Entrez Id: 3119
Gene Symbol: HLA-DQB1
HLA-DQB1
CUI: C0007847
Disease: Malignant tumor of cervix
Malignant tumor of cervix
0.100 GeneticVariation BEFREE Recently, it was demonstrated that there is a high risk for cervical cancer and CIN in women with HLA DQB1 * 03 (RR = 7.1, p < 0.0009) (1). 8529095

1995

Entrez Id: 3557
Gene Symbol: IL1RN
IL1RN
CUI: C0007847
Disease: Malignant tumor of cervix
Malignant tumor of cervix
0.090 AlteredExpression BEFREE Several human ovarian and cervical cancer cell lines spontaneously express the icIL-1Ra. icIL-1Ra-expressing cells did not have altered growth characteristics or altered short term responses to IL-1 compared with icIL-1Ra-nonexpressing cells. 7594609

1995

Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0007847
Disease: Malignant tumor of cervix
Malignant tumor of cervix
0.090 AlteredExpression BEFREE Several human ovarian and cervical cancer cell lines spontaneously express the icIL-1Ra. icIL-1Ra-expressing cells did not have altered growth characteristics or altered short term responses to IL-1 compared with icIL-1Ra-nonexpressing cells. 7594609

1995

Entrez Id: 3552
Gene Symbol: IL1A
IL1A
CUI: C0007847
Disease: Malignant tumor of cervix
Malignant tumor of cervix
0.050 AlteredExpression BEFREE Several human ovarian and cervical cancer cell lines spontaneously express the icIL-1Ra. icIL-1Ra-expressing cells did not have altered growth characteristics or altered short term responses to IL-1 compared with icIL-1Ra-nonexpressing cells. 7594609

1995

Entrez Id: 960
Gene Symbol: CD44
CD44
CUI: C0007847
Disease: Malignant tumor of cervix
Malignant tumor of cervix
0.040 AlteredExpression BEFREE Among the investigated CD44 splice variants expression of exon v6 is the most promising prognostic marker in surgically treated cervical cancer. 7539775

1995

Entrez Id: 2775
Gene Symbol: GNAO1
GNAO1
CUI: C0007847
Disease: Malignant tumor of cervix
Malignant tumor of cervix
0.010 GeneticVariation BEFREE Recently, it was demonstrated that there is a high risk for cervical cancer and CIN in women with HLA DQB1 * 03 (RR = 7.1, p < 0.0009) (1). 8529095

1995