Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 231
Gene Symbol: AKR1B1
AKR1B1
CUI: C0342257
Disease: Complications of Diabetes Mellitus
Complications of Diabetes Mellitus
0.400 Biomarker BEFREE The result should facilitate refined structural analysis and the development of new specific aldose reductase inhibitors for the treatment of diabetic complications. 2112546

1990

Entrez Id: 6517
Gene Symbol: SLC2A4
SLC2A4
CUI: C0342257
Disease: Complications of Diabetes Mellitus
Complications of Diabetes Mellitus
0.010 AlteredExpression BEFREE It is proposed that the decrease in GLUT4 levels is a protective mechanism, sparing skeletal muscle from gaining glucose and experiencing diabetic complications, albeit at the expense of becoming insulin resistant.(ABSTRACT TRUNCATED AT 400 WORDS) 1482748

1992

Entrez Id: 231
Gene Symbol: AKR1B1
AKR1B1
CUI: C0342257
Disease: Complications of Diabetes Mellitus
Complications of Diabetes Mellitus
0.400 GeneticVariation BEFREE Since aldose reductase is the first and ratelimiting enzyme of the polyol pathway, it is predicted that restriction fragment length polymorphisms at the aldose reductase gene locus may influence catalytic activity and determine individual susceptibility to the diabetic complications. 8104111

1993

Entrez Id: 1071
Gene Symbol: CETP
CETP
CUI: C0342257
Disease: Complications of Diabetes Mellitus
Complications of Diabetes Mellitus
0.010 GeneticVariation BEFREE In conclusion, the variation of CETP locus modulates the risk for diabetic complications in patients with NIDDM and the effect seems to be different between men and women. 7820935

1994

Entrez Id: 231
Gene Symbol: AKR1B1
AKR1B1
CUI: C0342257
Disease: Complications of Diabetes Mellitus
Complications of Diabetes Mellitus
0.400 Biomarker BEFREE One of the alleles (Z-2) was found to be associated with early onset of retinopathy in patients with non-insulin-dependent diabetes (P = 0.007), suggesting that aldose reductase or a gene in the close vicinity may be involved in the pathogenesis of this diabetic complication. 7789640

1995

Entrez Id: 6927
Gene Symbol: HNF1A
HNF1A
CUI: C0342257
Disease: Complications of Diabetes Mellitus
Complications of Diabetes Mellitus
0.040 GeneticVariation BEFREE Diabetes complications in NIDDM kindreds linked to the MODY3 locus on chromosome 12q. 8875082

1996

Entrez Id: 6647
Gene Symbol: SOD1
SOD1
CUI: C0342257
Disease: Complications of Diabetes Mellitus
Complications of Diabetes Mellitus
0.010 Biomarker BEFREE Our data using mutant Cu,Zn-SOD related to familial amyotrophic lateral sclerosis (FALS) suggest that glycation itself and ROI produced from the glycated proteins are involved in many diseases, including diabetic complications. 9044305

1996

Entrez Id: 2645
Gene Symbol: GCK
GCK
CUI: C0342257
Disease: Complications of Diabetes Mellitus
Complications of Diabetes Mellitus
0.010 GeneticVariation BEFREE To assess the prevalence of diabetes complications and the severity of diabetes in kindreds with NIDDM linked to the MODY3 locus (chromosome 12q) and to compare these parameters with data obtained in glucokinase (GCK)-deficient and other-MODY (unlinked to any of the three known loci) families, as well as with data from families with a late age of onset of NIDDM. 8875082

1996

Entrez Id: 231
Gene Symbol: AKR1B1
AKR1B1
CUI: C0342257
Disease: Complications of Diabetes Mellitus
Complications of Diabetes Mellitus
0.400 Biomarker BEFREE These results suggest that NO may be an endogenous regulator of aldose reductase, and consequently the polyol pathway of glucose metabolism; which has been implicated in the pathogenesis of secondary diabetic complications. 9357961

1997

Entrez Id: 6927
Gene Symbol: HNF1A
HNF1A
CUI: C0342257
Disease: Complications of Diabetes Mellitus
Complications of Diabetes Mellitus
0.040 Biomarker BEFREE In order to examine the prevalence of chronic diabetic complications in MODY3, we examined 57 carriers with HNF-1alpha mutations for the presence of micro- and macrovascular complications. 9562352

1998

Entrez Id: 231
Gene Symbol: AKR1B1
AKR1B1
CUI: C0342257
Disease: Complications of Diabetes Mellitus
Complications of Diabetes Mellitus
0.400 Biomarker BEFREE The identified protein is designated as RSOR because it is renal-specific with properties of an oxido-reductase, and like ALR2 it may be relevant in the renal complications of diabetes mellitus. 10944187

2000

Entrez Id: 217
Gene Symbol: ALDH2
ALDH2
CUI: C0342257
Disease: Complications of Diabetes Mellitus
Complications of Diabetes Mellitus
0.320 Biomarker BEFREE However, the HbA1c level of the light-to-moderate drinkers without diabetic complications in the inactive ALDH2 group was significantly higher and the incidence of 24 hr urinary C-peptide was higher than the respective level of the light-to-moderate drinkers without diabetic complications in the active ALDH2 group. 10803771

2000

Entrez Id: 55586
Gene Symbol: MIOX
MIOX
CUI: C0342257
Disease: Complications of Diabetes Mellitus
Complications of Diabetes Mellitus
0.020 Biomarker BEFREE The identified protein is designated as RSOR because it is renal-specific with properties of an oxido-reductase, and like ALR2 it may be relevant in the renal complications of diabetes mellitus. 10944187

2000

Entrez Id: 5054
Gene Symbol: SERPINE1
SERPINE1
CUI: C0342257
Disease: Complications of Diabetes Mellitus
Complications of Diabetes Mellitus
0.020 Biomarker BEFREE For this purpose we include 75 Caucasian diabetic patients (34 consecutive type I and 41 consecutive type II) without late diabetic complications.Lp(a) and PAI-1 were assessed by ELISA. 10946085

2000

Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
CUI: C0342257
Disease: Complications of Diabetes Mellitus
Complications of Diabetes Mellitus
0.010 AlteredExpression BEFREE Our study suggests that the alterations of TGF-beta1 levels could be associated with the activity of autoimmune process leading to pancreatic B cells destruction and may have a role in the pathogenesis of diabetic complications, but further studies in humans are needed. 10714434

2000

Entrez Id: 5973
Gene Symbol: RENBP
RENBP
CUI: C0342257
Disease: Complications of Diabetes Mellitus
Complications of Diabetes Mellitus
0.100 Biomarker BEFREE AGE-R2 and -R3 mRNA and protein levels were enhanced in both T1D groups (DC > n-DC) (n-DC AGE-R3, p < .05, DC AGE-R3, p < .05) compared to NL. 11471552

2001

Entrez Id: 847
Gene Symbol: CAT
CAT
CUI: C0342257
Disease: Complications of Diabetes Mellitus
Complications of Diabetes Mellitus
0.030 Biomarker BEFREE The data of this study reveal that enhanced catalase/SOD and catalase /PON ratios that are correlated with HbA1c levels are observed in diabetic patients; thus, these ratios may be used as markers of poor glycemic control and as risk factors in the development of diabetic complications. 11440784

2001

Entrez Id: 5589
Gene Symbol: PRKCSH
PRKCSH
CUI: C0342257
Disease: Complications of Diabetes Mellitus
Complications of Diabetes Mellitus
0.020 AlteredExpression BEFREE AGE-R2 and -R3 mRNA and protein levels were enhanced in both T1D groups (DC > n-DC) (n-DC AGE-R3, p < .05, DC AGE-R3, p < .05) compared to NL. 11471552

2001

Entrez Id: 1490
Gene Symbol: CCN2
CCN2
CUI: C0342257
Disease: Complications of Diabetes Mellitus
Complications of Diabetes Mellitus
0.020 Biomarker BEFREE Thus, AGE up-regulates the profibrotic and proangiogenic protein CTGF (IGFBP-rP2), a finding that may have significance in the development of diabetic complications. 11316739

2001

Entrez Id: 3651
Gene Symbol: PDX1
PDX1
CUI: C0342257
Disease: Complications of Diabetes Mellitus
Complications of Diabetes Mellitus
0.010 GeneticVariation BEFREE Transcription factor maturity-onset diabetes of the young, caused by mutations in the hepatocyte nuclear factor genes HNF-1alpha, HNF-4alpha and HNF-1beta, and in insulin promoter factor-1 results in a progressive beta-cell defect with increasing treatment requirements and diabetic complications. 11554773

2001

Entrez Id: 5973
Gene Symbol: RENBP
RENBP
CUI: C0342257
Disease: Complications of Diabetes Mellitus
Complications of Diabetes Mellitus
0.100 GeneticVariation BEFREE Although several gene polymorphisms are detected in most AGE-R components, no significant correlation to diabetic complications has as yet been found. 11757079

2002

Entrez Id: 213
Gene Symbol: ALB
ALB
CUI: C0342257
Disease: Complications of Diabetes Mellitus
Complications of Diabetes Mellitus
0.070 Biomarker LHGDN Thermodynamic analysis of human serum albumin interactions with glucose: insights into the diabetic range of glucose concentration. 12009306

2002

Entrez Id: 3077
Gene Symbol: HFE
HFE
CUI: C0342257
Disease: Complications of Diabetes Mellitus
Complications of Diabetes Mellitus
0.010 GeneticVariation BEFREE Aims of the study were: (i) to determine the prevalence of mutations C282Y and H63D in the HFE gene causing hereditary hemochromatosis in patients with type 2 diabetes mellitus and non-diabetics, (ii) to investigate the relationship among HFE genotypes, serum ferritin and glucose intolerance and (iii) to assess possible association of HFE mutations with the susceptibility to develop late diabetic complications in the Czech population. 12148086

2002

Entrez Id: 133
Gene Symbol: ADM
ADM
CUI: C0342257
Disease: Complications of Diabetes Mellitus
Complications of Diabetes Mellitus
0.010 Biomarker BEFREE Hence, the induction of vascular AM can be a new target of therapeutic approach to diabetic complications. 11747138

2002

Entrez Id: 231
Gene Symbol: AKR1B1
AKR1B1
CUI: C0342257
Disease: Complications of Diabetes Mellitus
Complications of Diabetes Mellitus
0.400 Biomarker BEFREE Together, these genetic studies strongly indicate that AR is an important target for the prevention of diabetic complications in human. 12871135

2003