Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3956
Gene Symbol: LGALS1
LGALS1
CUI: C0342257
Disease: Complications of Diabetes Mellitus
Complications of Diabetes Mellitus
0.010 Biomarker BEFREE Utilities, treatment costs and costs of diabetes-related complications (in pounds sterling [GBP]) were taken from published sources. 31833042

2020

Entrez Id: 8554
Gene Symbol: PIAS1
PIAS1
CUI: C0342257
Disease: Complications of Diabetes Mellitus
Complications of Diabetes Mellitus
0.010 Biomarker BEFREE Utilities, treatment costs and costs of diabetes-related complications (in pounds sterling [GBP]) were taken from published sources. 31833042

2020

Entrez Id: 54972
Gene Symbol: TMEM132A
TMEM132A
CUI: C0342257
Disease: Complications of Diabetes Mellitus
Complications of Diabetes Mellitus
0.010 Biomarker BEFREE Utilities, treatment costs and costs of diabetes-related complications (in pounds sterling [GBP]) were taken from published sources. 31833042

2020

Entrez Id: 3030
Gene Symbol: HADHA
HADHA
CUI: C0342257
Disease: Complications of Diabetes Mellitus
Complications of Diabetes Mellitus
0.010 Biomarker BEFREE Utilities, treatment costs and costs of diabetes-related complications (in pounds sterling [GBP]) were taken from published sources. 31833042

2020

Entrez Id: 114548
Gene Symbol: NLRP3
NLRP3
CUI: C0342257
Disease: Complications of Diabetes Mellitus
Complications of Diabetes Mellitus
0.010 Biomarker BEFREE In this review, we summarise the current understanding of the molecular mechanisms involved in pyroptosis, as well as recent advances in the role of NLRP3 inflammasome activation and pyroptosis in the development of diabetes and diabetic complications. 31809715

2020

Entrez Id: 3643
Gene Symbol: INSR
INSR
CUI: C0342257
Disease: Complications of Diabetes Mellitus
Complications of Diabetes Mellitus
0.010 GeneticVariation BEFREE Patients with mutations of the insulin receptor gene (INSR) have extreme insulin resistance and are at risk for early morbidity and mortality from diabetes complications. 31588494

2020

Entrez Id: 6442
Gene Symbol: SGCA
SGCA
CUI: C0342257
Disease: Complications of Diabetes Mellitus
Complications of Diabetes Mellitus
0.010 Biomarker BEFREE In this study, we measured the ratio in elderly patients with diabetes and evaluated its association with diabetic complications and disability in activities of daily living (ADL disability). 31672444

2020

Entrez Id: 10984
Gene Symbol: KCNQ1OT1
KCNQ1OT1
CUI: C0342257
Disease: Complications of Diabetes Mellitus
Complications of Diabetes Mellitus
0.010 Biomarker BEFREE Long noncoding RNA KCNQ1OT1 is involved in pathophysiological mechanisms of diabetic complications, including diabetic cardiomyopathy and diabetic retinopathy. 31693400

2020

Entrez Id: 7010
Gene Symbol: TEK
TEK
CUI: C0342257
Disease: Complications of Diabetes Mellitus
Complications of Diabetes Mellitus
0.010 Biomarker BEFREE Reduced angiopoietin-TIE2 receptor tyrosine kinase signaling in the vasculature leads to increased vascular permeability, inflammation, and endothelial cell loss and is associated with the development of diabetic complications. 30886059

2019

Entrez Id: 4311
Gene Symbol: MME
MME
CUI: C0342257
Disease: Complications of Diabetes Mellitus
Complications of Diabetes Mellitus
0.010 Biomarker BEFREE We also review the favourable impact neprilysin inhibition can have on diabetic complications, in addition to glucose control. 31089754

2019

Entrez Id: 57817
Gene Symbol: HAMP
HAMP
CUI: C0342257
Disease: Complications of Diabetes Mellitus
Complications of Diabetes Mellitus
0.010 AlteredExpression BEFREE The increased hepcidin may restrain the iron release from the cells by affecting the expression of ferroportin, which probably associates with the development of diabetes complication. 31699745

2019

Entrez Id: 57556
Gene Symbol: SEMA6A
SEMA6A
CUI: C0342257
Disease: Complications of Diabetes Mellitus
Complications of Diabetes Mellitus
0.010 Biomarker BEFREE The above pharmacological effects signify that HMG-R inhibitors and EZ (alone or in combination) may implied in the treatment of AGEs-induced oxidative stress and tissue damage in diabetic complications via targeting intracellular-ROS, NRP-1 functionality and RAGE-associated genes i.e.NF-κB, TGFβ-1, and MMP-2. 31476307

2019

Entrez Id: 55908
Gene Symbol: ANGPTL8
ANGPTL8
CUI: C0342257
Disease: Complications of Diabetes Mellitus
Complications of Diabetes Mellitus
0.010 Biomarker BEFREE This study highlights a possible predictive role of ANGPTL-8 in diabetic complications, particularly nephropathy. 31462941

2019

Entrez Id: 8074
Gene Symbol: FGF23
FGF23
CUI: C0342257
Disease: Complications of Diabetes Mellitus
Complications of Diabetes Mellitus
0.010 Biomarker BEFREE Objective Non-alcoholic fatty liver disease, steatohepatitis and nephropathy are considered among the most important complications of diabetes mellitus (DM), which recently increased due to increased frequency of DM and the prolonged life span of diabetic patients The aim of the present study was to reveal the possible effect of hesperidin (HP) on alpha-klotho (α-KL)/ fibroblast growth factor-23 (FGF-23) pathway in rats with diabetes induced by streptozotocin (STZ). 30551370

2019

Entrez Id: 27352
Gene Symbol: SGSM3
SGSM3
CUI: C0342257
Disease: Complications of Diabetes Mellitus
Complications of Diabetes Mellitus
0.010 AlteredExpression BEFREE The AGE-RAGE signaling pathway in diabetic complications and MAP kinase activity were determined as the main KEGG pathway and molecular function involved, respectively. 31210774

2019

Entrez Id: 55109
Gene Symbol: AGGF1
AGGF1
CUI: C0342257
Disease: Complications of Diabetes Mellitus
Complications of Diabetes Mellitus
0.010 Biomarker BEFREE These results suggest that <i>Aggf1</i> is required for essential function of EPCs, AGGF1 fully reverses the damaging effects of hyperglycemia on EPCs, and AGGF1 priming of EPCs is a novel treatment modality for vascular complications in DM. 31092480

2019

Entrez Id: 407040
Gene Symbol: MIR34A
MIR34A
CUI: C0342257
Disease: Complications of Diabetes Mellitus
Complications of Diabetes Mellitus
0.010 Biomarker BEFREE miR-34a is a multifunctional post-translational modulator, which is involved in several diabetes-related complications. 29529692

2019

Entrez Id: 27293
Gene Symbol: SMPDL3B
SMPDL3B
CUI: C0342257
Disease: Complications of Diabetes Mellitus
Complications of Diabetes Mellitus
0.010 Biomarker BEFREE Taken together, we identify SMPDL3b as a modulator of insulin signaling and demonstrate that supplementation with exogenous C1P may represent a lipid therapeutic strategy to treat diabetic complications such as DKD. 31217420

2019

Entrez Id: 8972
Gene Symbol: MGAM
MGAM
CUI: C0342257
Disease: Complications of Diabetes Mellitus
Complications of Diabetes Mellitus
0.010 Biomarker BEFREE Furthermore, the inhibition of α-amylase and α-glucosidase could prevent diabetic complications associated with postprandial glucose. 31353728

2019

Entrez Id: 51129
Gene Symbol: ANGPTL4
ANGPTL4
CUI: C0342257
Disease: Complications of Diabetes Mellitus
Complications of Diabetes Mellitus
0.010 Biomarker BEFREE Angiopoietin-like protein-4 (ANGPTL-4) has been reported to be dysregulated in diabetes mellitus and diabetic complications. 31387395

2019

Entrez Id: 378805
Gene Symbol: LINC-PINT
LINC-PINT
CUI: C0342257
Disease: Complications of Diabetes Mellitus
Complications of Diabetes Mellitus
0.010 AlteredExpression BEFREE RESULTS A comparison was made in this study, where LINC-PINT did not experience significant downregulation level in the majority of those suffering diabetes complications when in contrast to healthy controls, while LINC-PINT expression was found in diabetics. 31711064

2019

Entrez Id: 2729
Gene Symbol: GCLC
GCLC
CUI: C0342257
Disease: Complications of Diabetes Mellitus
Complications of Diabetes Mellitus
0.010 GeneticVariation BEFREE Given the participation of oxidative stress in the pathogenesis of diabetic complications, we evaluated, in type 1 diabetes (T1D) individuals, the association between diabetic retinopathy (DR) and functional single nucleotide polymorphisms (SNPs) in regulatory regions of two genes belonging to the antioxidant glutathione (GSH) system: rs17883901 in GCLC and rs713041 in GPX4. 30959073

2019

Entrez Id: 10724
Gene Symbol: OGA
OGA
CUI: C0342257
Disease: Complications of Diabetes Mellitus
Complications of Diabetes Mellitus
0.010 Biomarker BEFREE O-linked-β-N-Acetylglucosaminylation (O-GlcNAcylation), a reversible post-translational modification involved in diabetic complications, is regulated by only two enzymes, O-linked N-acetylglucosamine transferase (OGT) and β-N-Acetylglucosaminidase (OGA). 29890544

2019

Entrez Id: 246
Gene Symbol: ALOX15
ALOX15
CUI: C0342257
Disease: Complications of Diabetes Mellitus
Complications of Diabetes Mellitus
0.010 Biomarker BEFREE Here, we describe the function and role of human 12-LOX, and mouse 12-LOX and 12/15-LOX, in the development of diabetes and diabetes-related complications, and describe promise in the development of strategies to limit pro-inflammatory metabolites, primarily via new small molecule 12-LOX inhibitors. 30347209

2019

Entrez Id: 100422833
Gene Symbol: MIR3188
MIR3188
CUI: C0342257
Disease: Complications of Diabetes Mellitus
Complications of Diabetes Mellitus
0.010 Biomarker BEFREE miR-3188, one of the earliest discovered microRNAs, is involved in regulating the mTOR-p-PI3K/AKT pathway, thus affecting the progression of diabetic complications. 31274844

2019