Source: ALL

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 6927
Gene Symbol: HNF1A
HNF1A
CUI: C0342257
Disease: Complications of Diabetes Mellitus
Complications of Diabetes Mellitus 		0.040 GeneticVariation BEFREE Diabetes complications in NIDDM kindreds linked to the MODY3 locus on chromosome 12q. 8875082

1996
Entrez Id: 5589
Gene Symbol: PRKCSH
PRKCSH
CUI: C0342257
Disease: Complications of Diabetes Mellitus
Complications of Diabetes Mellitus 		0.020 AlteredExpression BEFREE AGE-R2 and -R3 mRNA and protein levels were enhanced in both T1D groups (DC > n-DC) (n-DC AGE-R3, p < .05, DC AGE-R3, p < .05) compared to NL. 11471552

2001
Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C0342257
Disease: Complications of Diabetes Mellitus
Complications of Diabetes Mellitus 		0.370 Biomarker BEFREE Vascular endothelial growth factor (VEGF) is a potent angiogenic and vascular permeability factor and is implicated in both of these diabetes complications. 14988276

2004
Entrez Id: 1906
Gene Symbol: EDN1
EDN1
CUI: C0342257
Disease: Complications of Diabetes Mellitus
Complications of Diabetes Mellitus 		0.020 Biomarker BEFREE Endothelin-1 (ET-1) is both a potent vasoconstrictor and mitogenic factor that has been implicated as a cause of the micro- and macrovascular complications of diabetes mellitus. 15010576

2004
Entrez Id: 231
Gene Symbol: AKR1B1
AKR1B1
CUI: C0342257
Disease: Complications of Diabetes Mellitus
Complications of Diabetes Mellitus 		0.400 Biomarker BEFREE Aldose reductase catalyzes the first step in the polyol pathway and is thought to be involved in the pathogenesis of diabetic complications. 15094999

2004
Entrez Id: 4153
Gene Symbol: MBL2
MBL2
CUI: C0342257
Disease: Complications of Diabetes Mellitus
Complications of Diabetes Mellitus 		0.010 Biomarker BEFREE MBL polymorphisms have been described that are associated with MBL serum concentration, impaired function, and diabetic complications. 16186405

2005
Entrez Id: 50639
Gene Symbol: MBL3P
MBL3P
CUI: C0342257
Disease: Complications of Diabetes Mellitus
Complications of Diabetes Mellitus 		0.010 GeneticVariation BEFREE MBL polymorphisms have been described that are associated with MBL serum concentration, impaired function, and diabetic complications. 16186405

2005
Entrez Id: 177
Gene Symbol: AGER
AGER
CUI: C0342257
Disease: Complications of Diabetes Mellitus
Complications of Diabetes Mellitus 		0.100 Biomarker BEFREE RAGE and its ligands: a lasting memory in diabetic complications? 16305050

2004
Entrez Id: 5891
Gene Symbol: MOK
MOK
CUI: C0342257
Disease: Complications of Diabetes Mellitus
Complications of Diabetes Mellitus 		0.030 Biomarker BEFREE RAGE and its ligands: a lasting memory in diabetic complications? 16305050

2004
Entrez Id: 5973
Gene Symbol: RENBP
RENBP
CUI: C0342257
Disease: Complications of Diabetes Mellitus
Complications of Diabetes Mellitus 		0.100 Biomarker BEFREE AGE contribute to the pathogenesis of diabetic complications, including dyslipidaemia and atherosclerosis. 17579831

2007
Entrez Id: 5579
Gene Symbol: PRKCB
PRKCB
CUI: C0342257
Disease: Complications of Diabetes Mellitus
Complications of Diabetes Mellitus 		0.020 Biomarker BEFREE Protein kinase C-beta (PKC-beta) is a cell-signaling intermediate implicated in development of diabetic complications. 20736472

2010
Entrez Id: 7057
Gene Symbol: THBS1
THBS1
CUI: C0342257
Disease: Complications of Diabetes Mellitus
Complications of Diabetes Mellitus 		0.020 Biomarker BEFREE Thrombospondin-1 is a potent antiangiogenic protein associated with development of several diabetic complications and regulated by high glucose in multiple cell types. 21148424

2011
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
CUI: C0342257
Disease: Complications of Diabetes Mellitus
Complications of Diabetes Mellitus 		0.030 Biomarker BEFREE Chemokine (C-C motif) ligand 2 (CCL2) in sera of patients with type 1 diabetes and diabetic complications. 21532752

2011
Entrez Id: 406938
Gene Symbol: MIR146A
MIR146A
CUI: C0342257
Disease: Complications of Diabetes Mellitus
Complications of Diabetes Mellitus 		0.020 Biomarker BEFREE miR-146a-Mediated extracellular matrix protein production in chronic diabetes complications. 21885871

2011
Entrez Id: 23771
Gene Symbol: DIANPH
DIANPH
CUI: C0342257
Disease: Complications of Diabetes Mellitus
Complications of Diabetes Mellitus 		0.040 Biomarker BEFREE Diabetic nephropathy and retinopathy are two important microvascular diabetes complications with a high concordance rate in diabetic patients. 21911749

2011
Entrez Id: 283297
Gene Symbol: OR10A4
OR10A4
CUI: C0342257
Disease: Complications of Diabetes Mellitus
Complications of Diabetes Mellitus 		0.040 GeneticVariation BEFREE Hp 2-2 DM individuals have been shown to be at increased risk for the development of diabetes complications, particularly diabetic cardiovascular disease (CVD). 22427005

2012
Entrez Id: 231
Gene Symbol: AKR1B1
AKR1B1
CUI: C0342257
Disease: Complications of Diabetes Mellitus
Complications of Diabetes Mellitus 		0.400 Biomarker BEFREE Aldose reductase (AR), an enzyme mediating the first step in the polyol pathway of glucose metabolism, is associated with complications of diabetes mellitus and increased cardiac ischemic injury. 23029549

2012
Entrez Id: 7108
Gene Symbol: TM7SF2
TM7SF2
CUI: C0342257
Disease: Complications of Diabetes Mellitus
Complications of Diabetes Mellitus 		0.010 Biomarker BEFREE Ang1 helps delay diabetic complications by restoring microvascular function and can maintain the quiescence of some adult stem cells. 23182855

2013
Entrez Id: 284
Gene Symbol: ANGPT1
ANGPT1
CUI: C0342257
Disease: Complications of Diabetes Mellitus
Complications of Diabetes Mellitus 		0.010 Biomarker BEFREE Ang1 helps delay diabetic complications by restoring microvascular function and can maintain the quiescence of some adult stem cells. 23182855

2013
Entrez Id: 3240
Gene Symbol: HP
HP
CUI: C0342257
Disease: Complications of Diabetes Mellitus
Complications of Diabetes Mellitus 		0.370 GeneticVariation BEFREE Haptoglobin (Hp) genotype (Hp 1-1, 1-2, or 2-2) is associated with risk for type 2 diabetes complications, but its relationship with cognitive compromise, a growing concern in type 2 diabetes, has rarely been studied. 23990521

2013
Entrez Id: 5054
Gene Symbol: SERPINE1
SERPINE1
CUI: C0342257
Disease: Complications of Diabetes Mellitus
Complications of Diabetes Mellitus 		0.020 GeneticVariation BEFREE PAI-1 -675 4G/5G polymorphism in association with diabetes and diabetic complications susceptibility: a meta-analysis study. 24223897

2013
Entrez Id: 2739
Gene Symbol: GLO1
GLO1
CUI: C0342257
Disease: Complications of Diabetes Mellitus
Complications of Diabetes Mellitus 		0.040 Biomarker BEFREE Glo1 is linked to healthy aging, obesity, diabetes and diabetic complications, chronic renal disease, cardiovascular disease, other disorders and multidrug resistance in cancer chemotherapy. 24646254

2014
Entrez Id: 3240
Gene Symbol: HP
HP
CUI: C0342257
Disease: Complications of Diabetes Mellitus
Complications of Diabetes Mellitus 		0.370 GeneticVariation BEFREE Haptoglobin (Hp) genotype 2-2 increases cardiovascular diabetes complications. 26002590

2016
Entrez Id: 10628
Gene Symbol: TXNIP
TXNIP
CUI: C0342257
Disease: Complications of Diabetes Mellitus
Complications of Diabetes Mellitus 		0.010 AlteredExpression BEFREE Thioredoxin interacting protein (TXNIP), an inhibitor of antioxidant thioredoxin (Trx), is upregulated by hyperglycemia and implicated in pathogenesis of diabetes complications. 26480949

2016
Entrez Id: 406991
Gene Symbol: MIR21
MIR21
CUI: C0342257
Disease: Complications of Diabetes Mellitus
Complications of Diabetes Mellitus 		0.010 AlteredExpression BEFREE MiR-21-5p and miR-126a-3p levels in plasma and circulating angiogenic cells: relationship with type 2 diabetes complications. 26498351

2015