×
Entrez Id:
6927
Gene Symbol:
HNF1A
HNF1A
Complications of Diabetes Mellitus
0.040
GeneticVariation
BEFREE
Diabetes complications in NIDDM kindreds linked to the MODY3 locus on chromosome 12q.
8875082
1996
×
Entrez Id:
5589
Gene Symbol:
PRKCSH
PRKCSH
Complications of Diabetes Mellitus
0.020
AlteredExpression
BEFREE
AGE-R2 and -R3 mRNA and protein levels were enhanced in both T1D groups (DC > n-DC ) (n-DC AGE-R3, p < .05, DC AGE-R3, p < .05) compared to NL.
11471552
2001
×
Entrez Id:
7422
Gene Symbol:
VEGFA
VEGFA
Complications of Diabetes Mellitus
0.370
Biomarker
BEFREE
Vascular endothelial growth factor (VEGF ) is a potent angiogenic and vascular permeability factor and is implicated in both of these diabetes complications .
14988276
2004
×
Entrez Id:
1906
Gene Symbol:
EDN1
EDN1
Complications of Diabetes Mellitus
0.020
Biomarker
BEFREE
Endothelin-1 (ET-1 ) is both a potent vasoconstrictor and mitogenic factor that has been implicated as a cause of the micro- and macrovascular complications of diabetes mellitus .
15010576
2004
×
Entrez Id:
231
Gene Symbol:
AKR1B1
AKR1B1
Complications of Diabetes Mellitus
0.400
Biomarker
BEFREE
Aldose reductase catalyzes the first step in the polyol pathway and is thought to be involved in the pathogenesis of diabetic complications .
15094999
2004
×
Entrez Id:
4153
Gene Symbol:
MBL2
MBL2
Complications of Diabetes Mellitus
0.010
Biomarker
BEFREE
MBL polymorphisms have been described that are associated with MBL serum concentration, impaired function, and diabetic complications .
16186405
2005
×
Entrez Id:
50639
Gene Symbol:
MBL3P
MBL3P
Complications of Diabetes Mellitus
0.010
GeneticVariation
BEFREE
MBL polymorphisms have been described that are associated with MBL serum concentration, impaired function, and diabetic complications .
16186405
2005
×
Entrez Id:
177
Gene Symbol:
AGER
AGER
Complications of Diabetes Mellitus
0.100
Biomarker
BEFREE
RAGE and its ligands: a lasting memory in diabetic complications ?
16305050
2004
×
Entrez Id:
5891
Gene Symbol:
MOK
MOK
Complications of Diabetes Mellitus
0.030
Biomarker
BEFREE
RAGE and its ligands: a lasting memory in diabetic complications ?
16305050
2004
×
Entrez Id:
5973
Gene Symbol:
RENBP
RENBP
Complications of Diabetes Mellitus
0.100
Biomarker
BEFREE
AGE contribute to the pathogenesis of diabetic complications , including dyslipidaemia and atherosclerosis.
17579831
2007
×
Entrez Id:
5579
Gene Symbol:
PRKCB
PRKCB
Complications of Diabetes Mellitus
0.020
Biomarker
BEFREE
Protein kinase C-beta (PKC-beta ) is a cell-signaling intermediate implicated in development of diabetic complications .
20736472
2010
×
Entrez Id:
7057
Gene Symbol:
THBS1
THBS1
Complications of Diabetes Mellitus
0.020
Biomarker
BEFREE
Thrombospondin-1 is a potent antiangiogenic protein associated with development of several diabetic complications and regulated by high glucose in multiple cell types.
21148424
2011
×
Entrez Id:
6347
Gene Symbol:
CCL2
CCL2
Complications of Diabetes Mellitus
0.030
Biomarker
BEFREE
Chemokine (C-C motif) ligand 2 (CCL2 ) in sera of patients with type 1 diabetes and diabetic complications .
21532752
2011
×
Entrez Id:
406938
Gene Symbol:
MIR146A
MIR146A
Complications of Diabetes Mellitus
0.020
Biomarker
BEFREE
miR-146a -Mediated extracellular matrix protein production in chronic diabetes complications .
21885871
2011
×
Entrez Id:
23771
Gene Symbol:
DIANPH
DIANPH
Complications of Diabetes Mellitus
0.040
Biomarker
BEFREE
Diabetic nephropathy and retinopathy are two important microvascular diabetes complications with a high concordance rate in diabetic patients.
21911749
2011
×
Entrez Id:
283297
Gene Symbol:
OR10A4
OR10A4
Complications of Diabetes Mellitus
0.040
GeneticVariation
BEFREE
Hp 2 -2 DM individuals have been shown to be at increased risk for the development of diabetes complications , particularly diabetic cardiovascular disease (CVD).
22427005
2012
×
Entrez Id:
231
Gene Symbol:
AKR1B1
AKR1B1
Complications of Diabetes Mellitus
0.400
Biomarker
BEFREE
Aldose reductase (AR ), an enzyme mediating the first step in the polyol pathway of glucose metabolism, is associated with complications of diabetes mellitus and increased cardiac ischemic injury.
23029549
2012
×
Entrez Id:
7108
Gene Symbol:
TM7SF2
TM7SF2
Complications of Diabetes Mellitus
0.010
Biomarker
BEFREE
Ang1 helps delay diabetic complications by restoring microvascular function and can maintain the quiescence of some adult stem cells.
23182855
2013
×
Entrez Id:
284
Gene Symbol:
ANGPT1
ANGPT1
Complications of Diabetes Mellitus
0.010
Biomarker
BEFREE
Ang1 helps delay diabetic complications by restoring microvascular function and can maintain the quiescence of some adult stem cells.
23182855
2013
×
Entrez Id:
3240
Gene Symbol:
HP
HP
Complications of Diabetes Mellitus
0.370
GeneticVariation
BEFREE
Haptoglobin (Hp ) genotype (Hp 1-1, 1-2, or 2-2) is associated with risk for type 2 diabetes complications , but its relationship with cognitive compromise, a growing concern in type 2 diabetes, has rarely been studied.
23990521
2013
SERPINE1
Complications of Diabetes Mellitus
0.020
GeneticVariation
BEFREE
PAI-1 -675 4G/5G polymorphism in association with diabetes and diabetic complications susceptibility: a meta-analysis study.
24223897
2013
×
Entrez Id:
2739
Gene Symbol:
GLO1
GLO1
Complications of Diabetes Mellitus
0.040
Biomarker
BEFREE
Glo1 is linked to healthy aging, obesity, diabetes and diabetic complications , chronic renal disease, cardiovascular disease, other disorders and multidrug resistance in cancer chemotherapy.
24646254
2014
×
Entrez Id:
3240
Gene Symbol:
HP
HP
Complications of Diabetes Mellitus
0.370
GeneticVariation
BEFREE
Haptoglobin (Hp ) genotype 2-2 increases cardiovascular diabetes complications .
26002590
2016
×
Entrez Id:
10628
Gene Symbol:
TXNIP
TXNIP
Complications of Diabetes Mellitus
0.010
AlteredExpression
BEFREE
Thioredoxin interacting protein (TXNIP ), an inhibitor of antioxidant thioredoxin (Trx), is upregulated by hyperglycemia and implicated in pathogenesis of diabetes complications .
26480949
2016
×
Entrez Id:
406991
Gene Symbol:
MIR21
MIR21
Complications of Diabetes Mellitus
0.010
AlteredExpression
BEFREE
MiR-21 -5p and miR-126a-3p levels in plasma and circulating angiogenic cells: relationship with type 2 diabetes complications .
26498351
2015