×
Entrez Id: 472
Gene Symbol: ATM
ATM
Mammary Neoplasms
0.500
GeneticVariation
LHGDN
ATM variants and cancer risk in breast cancer patients from Southern Finland.
16914028 2006
×
Entrez Id: 472
Gene Symbol: ATM
ATM
Mammary Neoplasms
0.500
GeneticVariation
LHGDN
Single nucleotide polymorphism D1853N of the ATM gene may alter the risk for breast cancer.
18264724 2008
×
Entrez Id: 472
Gene Symbol: ATM
ATM
Mammary Neoplasms
0.500
GeneticVariation
LHGDN
Dominant negative ATM mutations in breast cancer families.
11830610 2002
×
Entrez Id: 472
Gene Symbol: ATM
ATM
Mammary Neoplasms
0.500
AlteredExpression
BEFREE
We used qRT-PCR assay to quantify mRNA levels of ATM gene in 454 breast tumours from patients with known clinical/pathological status and outcome; reverse phase protein arrays (RPPA) were used to assess the levels of ATM and 14 proteins in 233 breast tumours .
25742469 2015
×
Entrez Id: 472
Gene Symbol: ATM
ATM
Mammary Neoplasms
0.500
GeneticVariation
LHGDN
We have found that carriers of an ATM missense mutation, who were treated with radiotherapy for the first breast tumour , developed their second tumour on average in a 92-month interval compared to a 136-month mean interval for those CBC patients who neither received RT nor carried a germline variant, (p = 0.029).
17393301 2008
×
Entrez Id: 472
Gene Symbol: ATM
ATM
Mammary Neoplasms
0.500
GeneticVariation
LHGDN
Evaluation of the role of Finnish ataxia-telangiectasia mutations in hereditary predisposition to breast cancer.
17166884 2007
×
Entrez Id: 472
Gene Symbol: ATM
ATM
Mammary Neoplasms
0.500
Biomarker
BEFREE
Our findings provide the first experimental evidence that ATM is a human breast tumor suppressor.
20177072 2010
×
Entrez Id: 472
Gene Symbol: ATM
ATM
Mammary Neoplasms
0.500
GeneticVariation
LHGDN
Elevated frequency of ATM gene missense mutations in breast cancer relative to ethnically matched controls.
11996792 2002
×
Entrez Id: 472
Gene Symbol: ATM
ATM
Mammary Neoplasms
0.500
Biomarker
LHGDN
Two ATM variants and breast cancer risk.
15880680 2005
×
Entrez Id: 472
Gene Symbol: ATM
ATM
Mammary Neoplasms
0.500
Biomarker
LHGDN
Consortium piecing together role of ATM gene in breast cancer.
11830600 2002
×
Entrez Id: 472
Gene Symbol: ATM
ATM
Mammary Neoplasms
0.500
GeneticVariation
LHGDN
Contributions of ATM mutations to familial breast and ovarian cancer.
12810666 2003
×
Entrez Id: 472
Gene Symbol: ATM
ATM
Mammary Neoplasms
0.500
AlteredExpression
BEFREE
Fifty-two breast tumors from 51 patients, 38 of them with concomitant in situ component (CIS), were analyzed by immunohistochemistry for the expression of ATM .
16329039 2006
×
Entrez Id: 472
Gene Symbol: ATM
ATM
Mammary Neoplasms
0.500
AlteredExpression
BEFREE
Loss of heterozygosity at the ATM locus has been reported in 30-40% of breast tumours and 50-70% show altered ATM protein levels.
16112413 2005
×
Entrez Id: 472
Gene Symbol: ATM
ATM
Mammary Neoplasms
0.500
GeneticVariation
LHGDN
Cancer risks and mortality in heterozygous ATM mutation carriers.
15928302 2005
×
Entrez Id: 472
Gene Symbol: ATM
ATM
Mammary Neoplasms
0.500
Biomarker
BEFREE
We also studied breast tumors from ATM mutants, and three showed retention of both alleles, whereas the fourth showed loss of the mutant allele.
9537233 1998
×
Entrez Id: 472
Gene Symbol: ATM
ATM
Mammary Neoplasms
0.500
GeneticVariation
BEFREE
We screened a cohort of 173 nonselected primary breast tumors for LOH in a 4 cM region at 11q23 spanning the ATM gene.
11793440 2002
×
Entrez Id: 472
Gene Symbol: ATM
ATM
Mammary Neoplasms
0.500
GeneticVariation
LHGDN
Cancer risk according to type and location of ATM mutation in ataxia-telangiectasia families.
15390180 2005
×
Entrez Id: 472
Gene Symbol: ATM
ATM
Mammary Neoplasms
0.500
GeneticVariation
LHGDN
Association of common ATM variants with familial breast cancer in a South American population.
18433505 2008
×
Entrez Id: 472
Gene Symbol: ATM
ATM
Mammary Neoplasms
0.500
GeneticVariation
BEFREE
Loss of heterozygosity (LOH) in the ATM region of chromosome 11q23.1 showed that the normal ATM allele was lost in the breast tumor of the older sister.
10571946 1999
×
Entrez Id: 472
Gene Symbol: ATM
ATM
Mammary Neoplasms
0.500
GeneticVariation
BEFREE
So far, no clear histopathological and molecular features of breast tumours occurring in ATM deleterious variant carriers have been described, but identification of an ATM-associated tumour signature may help in patient management.
29665859 2018
×
Entrez Id: 472
Gene Symbol: ATM
ATM
Mammary Neoplasms
0.500
Biomarker
LHGDN
Characterization of the breast cancer associated ATM 7271T>G (V2424G) mutation by gene expression profiling.
17001622 2006
×
Entrez Id: 472
Gene Symbol: ATM
ATM
Mammary Neoplasms
0.500
GeneticVariation
LHGDN
ATM and breast cancer susceptibility.
16998505 2006
×
Entrez Id: 472
Gene Symbol: ATM
ATM
Mammary Neoplasms
0.500
PosttranslationalModification
LHGDN
These findings indicate that epigenetic silencing of ATM expression occurs in locally advanced breast tumors , and establish a link at the molecular level between reduced ATM function and sporadic breast malignancy.
15516988 2004
×
Entrez Id: 472
Gene Symbol: ATM
ATM
Mammary Neoplasms
0.500
GeneticVariation
LHGDN
ATM allelic variants associated to hereditary breast cancer in 94 Chilean women: susceptibility or ethnic influences?
17351744 2008
×
Entrez Id: 472
Gene Symbol: ATM
ATM
Mammary Neoplasms
0.500
Biomarker
LHGDN
Are the so-called low penetrance breast cancer genes, ATM, BRIP1, PALB2 and CHEK2, high risk for women with strong family histories?
18557994 2008