×
Entrez Id: 4513
Gene Symbol: COX2
COX2
Primary malignant neoplasm of lung
0.100
GeneticVariation
BEFREE
The association between lung cancer incidence and survival and 23 polymorphisms descriptive of 11 inflammation-related genes (interferon gamma gene [IFNG], interleukin 10 gene [IL10], interleukin 1 alpha gene [IL1A], interleukin 1 beta gene [IL1B], interleukin 2 gene [IL2], interleukin 4 receptor gene [IL4R], interleukin 4 gene [IL4], interleukin 6 gene [IL6], prostaglandin-endoperoxide synthase 2 gene [PTGS2] (also known as COX2 ), transforming growth factor beta 1 gene [TGFB1], and tumor necrosis factor alpha gene [TNFA]) was evaluated.
29408308 2018
×
Entrez Id: 4513
Gene Symbol: COX2
COX2
Primary malignant neoplasm of lung
0.100
GeneticVariation
BEFREE
COX-2 rs5275 and rs689466 polymorphism and risk of lung cancer : A PRISMA-compliant meta-analysis.30170377 2018
×
Entrez Id: 4513
Gene Symbol: COX2
COX2
Primary malignant neoplasm of lung
0.100
GeneticVariation
BEFREE
CONCLUSIONS In COX-2 gene, rs20417 may have a certain relationship with reduced risk of lung cancer , while rs2066826 may increase the risk of lung cancer .
26624903 2015
×
Entrez Id: 4513
Gene Symbol: COX2
COX2
Primary malignant neoplasm of lung
0.100
GeneticVariation
BEFREE
There was interaction between IL-1B T-31C , COX-2 A-1195G and PPARgamma2 Pro(12)Ala and NSAID use in relation to lung cancer risk.
18164040 2008
×
Entrez Id: 4513
Gene Symbol: COX2
COX2
Primary malignant neoplasm of lung
0.100
GeneticVariation
BEFREE
TNF-α 308G/A , IL-6 174G/C , IL-1β 31T/C , IL-1β 511C/T , COX-2 8473T/C polymorphisms were not detected to be related to the risk for LC .
22160576 2012
×
Entrez Id: 4513
Gene Symbol: COX2
COX2
Primary malignant neoplasm of lung
0.100
GeneticVariation
BEFREE
We found that carriers of the C allele of a polymorphism in the 3'-UTR of COX2 had a significantly increased risk of lung cancer , with odds ratios of 4.28 (95% CI, 2.44-7.49) for homozygotes and 2.12 (95% CI, 1.25-3.59) for heterozygotes.
14604894 2004
×
Entrez Id: 4513
Gene Symbol: COX2
COX2
Primary malignant neoplasm of lung
0.100
GeneticVariation
BEFREE
Taken together, this meta-analysis suggests that the COX 2 T8473C polymorphism is not associated with lung cancer risk.
22292629 2011
×
Entrez Id: 4513
Gene Symbol: COX2
COX2
Primary malignant neoplasm of lung
0.100
GeneticVariation
BEFREE
These findings indicate that the COX-2 T8473C polymorphism may contribute to lung cancer susceptibility in the Chinese population.
15777967 2005
×
Entrez Id: 4513
Gene Symbol: COX2
COX2
Primary malignant neoplasm of lung
0.100
Biomarker
BEFREE
Our findings imply that a COX-2 inhibitor might improve the prognosis of patients with lung cancer through the reduction of G-CSF or GM-CSF.
12708493 2003
×
Entrez Id: 4513
Gene Symbol: COX2
COX2
Primary malignant neoplasm of lung
0.100
Biomarker
BEFREE
The THP-1, monocytic leukemia cell line effectively absorbed COX-2 by lung cancer cell-derived exosomes.
29345286 2018
×
Entrez Id: 4513
Gene Symbol: COX2
COX2
Primary malignant neoplasm of lung
0.100
Biomarker
BEFREE
p38 MAPK, ERK, and COX-2 activation are novel mediators for the galectin-1-promoted tumor progression and chemoresistance in lung cancer .
22696230 2012
×
Entrez Id: 4513
Gene Symbol: COX2
COX2
Primary malignant neoplasm of lung
0.100
Biomarker
BEFREE
Induction but not inhibition of COX-2 confers human lung cancer cell apoptosis by celecoxib.
23943857 2013
×
Entrez Id: 4513
Gene Symbol: COX2
COX2
Primary malignant neoplasm of lung
0.100
Biomarker
BEFREE
In this study, we showed that IGFBP-4 could decrease COX-2 production in lung cancer A549 cells.
28150906 2017
×
Entrez Id: 4513
Gene Symbol: COX2
COX2
Primary malignant neoplasm of lung
0.100
Biomarker
BEFREE
Thus, COX-2 is likely important in lung tumorigenesis, and COX-2 and its product, PGE2, are potential targets for lung cancer prevention.
26452035 2015
×
Entrez Id: 4513
Gene Symbol: COX2
COX2
Primary malignant neoplasm of lung
0.100
Biomarker
BEFREE
Inhibition of mPGES-1 or COX-2 Results in Different Proteomic and Lipidomic Profiles in A549 Lung Cancer Cells.
31231223 2019
×
Entrez Id: 4513
Gene Symbol: COX2
COX2
Primary malignant neoplasm of lung
0.100
Biomarker
BEFREE
Role of LKB1-CRTC1 on glycosylated COX-2 and response to COX-2 inhibition in lung cancer .
25465874 2015
×
Entrez Id: 4513
Gene Symbol: COX2
COX2
Primary malignant neoplasm of lung
0.100
Biomarker
BEFREE
Our study provides pharmacological evidence that CS-6 exhibits potential use in the treatment of COX-2 -mediated diseases such as lung cancer .
25175164 2014
×
Entrez Id: 4513
Gene Symbol: COX2
COX2
Primary malignant neoplasm of lung
0.100
Biomarker
BEFREE
In the present study, the ability of meloxicam, a COX-2 -specific inhibitor to enhance doxorubicin‑mediated inhibition was investigated in human A549 lung cancer in vivo and in vitro.
26600514 2015
×
Entrez Id: 4513
Gene Symbol: COX2
COX2
Primary malignant neoplasm of lung
0.100
Biomarker
BEFREE
Disruption of Chromosomal Architecture of cox2 Locus Sensitizes Lung Cancer Cells to Radiotherapy.
30131302 2018
×
Entrez Id: 4513
Gene Symbol: COX2
COX2
Primary malignant neoplasm of lung
0.100
Biomarker
BEFREE
MiR-26b suppresses tumor cell proliferation, migration and invasion by directly targeting COX-2 in lung cancer .
26744864 2015
×
Entrez Id: 4513
Gene Symbol: COX2
COX2
Primary malignant neoplasm of lung
0.100
Biomarker
BEFREE
Although preclinical studies have suggested that aspirin and Cox-2 inhibitors may influence the progression of lung cancer , the molecular mechanisms of these protective effects in this tumor type has not been fully elucidated.
17342322 2007
×
Entrez Id: 4513
Gene Symbol: COX2
COX2
Primary malignant neoplasm of lung
0.100
Biomarker
BEFREE
Inhibition of COX-2 and EGFR by Melafolone Improves Anti-PD-1 Therapy through Vascular Normalization and PD-L1 Downregulation in Lung Cancer .
30591531 2019
×
Entrez Id: 4513
Gene Symbol: COX2
COX2
Primary malignant neoplasm of lung
0.100
Biomarker
BEFREE
Further, while COX-2 itself is known to be inducible in inflammation, COX-2 expression levels correlated well with the capabilities of these clones for not only in vitro motility and invasion but also in vivo metastasis, and COX-2 inhibitors were shown for the first time to reduce lung cancer metastasis in vivo.
11464289 2001
×
Entrez Id: 4513
Gene Symbol: COX2
COX2
Primary malignant neoplasm of lung
0.100
Biomarker
BEFREE
Further investigations showed that the PI3K/Akt signalling pathway and COX-2 are involved in endothelial tube formation under the stimulation of lung cancer cells.
28173828 2017
×
Entrez Id: 4513
Gene Symbol: COX2
COX2
Primary malignant neoplasm of lung
0.100
Biomarker
BEFREE
However, treatment of lung cancer cell lines with a COX2 inhibitor had no impact on PD-L1 expression.
30061230 2018