Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 231
Gene Symbol: AKR1B1
AKR1B1
CUI: C0342257
Disease: Complications of Diabetes Mellitus
Complications of Diabetes Mellitus
0.400 AlteredExpression BEFREE Key findings are that (a) low doses of Nasonia venom elevate sorbitol levels in human renal mesangial cells (HRMCs) without changing glucose or fructose levels; (b) venom is a much more potent inducer of sorbitol elevation than glucose; (c) low venom doses significantly alter expression of genes involved in sterol and alcohol metabolism, transcriptional regulation, and chemical/stimulus response; (d) although venom treatment does not alter expression of the key sorbitol pathway gene aldose reductase (AR); (e) venom elevates expression of a related gene implicated in diabetes complications (AKR1C3) as well as the fructose metabolic gene (GFPT2). 30831148

2019

Entrez Id: 231
Gene Symbol: AKR1B1
AKR1B1
CUI: C0342257
Disease: Complications of Diabetes Mellitus
Complications of Diabetes Mellitus
0.400 Biomarker BEFREE Together, these genetic studies strongly indicate that AR is an important target for the prevention of diabetic complications in human. 12871135

2003

Entrez Id: 231
Gene Symbol: AKR1B1
AKR1B1
CUI: C0342257
Disease: Complications of Diabetes Mellitus
Complications of Diabetes Mellitus
0.400 Biomarker BEFREE One of the alleles (Z-2) was found to be associated with early onset of retinopathy in patients with non-insulin-dependent diabetes (P = 0.007), suggesting that aldose reductase or a gene in the close vicinity may be involved in the pathogenesis of this diabetic complication. 7789640

1995

Entrez Id: 231
Gene Symbol: AKR1B1
AKR1B1
CUI: C0342257
Disease: Complications of Diabetes Mellitus
Complications of Diabetes Mellitus
0.400 Biomarker BEFREE Investigation of the cause of BmAR downregulation in the q-l<sup>p</sup> mutant could contribute to revealing the function of AR in insects and offers a new method of identifying AR inhibitors for the treatment of diabetic complications. 29730425

2018

Entrez Id: 231
Gene Symbol: AKR1B1
AKR1B1
CUI: C0342257
Disease: Complications of Diabetes Mellitus
Complications of Diabetes Mellitus
0.400 AlteredExpression BEFREE Oxidative stress and aldose reductase activity have been implicated in the development of diabetic complications. 28484711

2017

Entrez Id: 231
Gene Symbol: AKR1B1
AKR1B1
CUI: C0342257
Disease: Complications of Diabetes Mellitus
Complications of Diabetes Mellitus
0.400 GeneticVariation BEFREE The C-106T polymorphism of AKR1B1 is closely related to the diabetic complications. 27343777

2016

Entrez Id: 231
Gene Symbol: AKR1B1
AKR1B1
CUI: C0342257
Disease: Complications of Diabetes Mellitus
Complications of Diabetes Mellitus
0.400 Biomarker BEFREE Aldose reductase (AR) inhibitors play a vital importance as a potential therapeutic and preventive medicine when it comes to hyperglycemia associated diabetic complications. 28217947

2017

Entrez Id: 231
Gene Symbol: AKR1B1
AKR1B1
CUI: C0342257
Disease: Complications of Diabetes Mellitus
Complications of Diabetes Mellitus
0.400 Biomarker BEFREE To develop multifunctional aldose reductase (AKR1B1) inhibitors for anti-diabetic complications, a novel series of 2-phenoxypyrido[3,2-<i>b</i>]pyrazin-3(4<i>H</i>)-one derivatives were designed and synthesised. 31347930

2019

Entrez Id: 231
Gene Symbol: AKR1B1
AKR1B1
CUI: C0342257
Disease: Complications of Diabetes Mellitus
Complications of Diabetes Mellitus
0.400 Biomarker BEFREE Therefore, aldose reductase (AR) and advanced glycation endproducts (AGEs) formation has significant effect on diabetic complications. 28512639

2017

Entrez Id: 231
Gene Symbol: AKR1B1
AKR1B1
CUI: C0342257
Disease: Complications of Diabetes Mellitus
Complications of Diabetes Mellitus
0.400 Biomarker BEFREE Aldose reductase (AR), an enzyme mediating the first step in the polyol pathway of glucose metabolism, is associated with complications of diabetes mellitus and increased cardiac ischemic injury. 23029549

2012

Entrez Id: 231
Gene Symbol: AKR1B1
AKR1B1
CUI: C0342257
Disease: Complications of Diabetes Mellitus
Complications of Diabetes Mellitus
0.400 Biomarker BEFREE Humans exhibit three members of the AKR1B subfamily: AKR1B1 (aldose reductase, participates in diabetes complications), AKR1B10 (overexpressed in several cancer types), and the recently described AKR1B15. 31028727

2019

Entrez Id: 231
Gene Symbol: AKR1B1
AKR1B1
CUI: C0342257
Disease: Complications of Diabetes Mellitus
Complications of Diabetes Mellitus
0.400 Biomarker BEFREE The newly discovered RSOR has certain structural and functional similarities to AKR1B and seems to be relevant to the renal complications of diabetes mellitus. 12871137

2003

Entrez Id: 231
Gene Symbol: AKR1B1
AKR1B1
CUI: C0342257
Disease: Complications of Diabetes Mellitus
Complications of Diabetes Mellitus
0.400 Biomarker BEFREE Aldose reductase (AR), a member of aldo-keto reductase family, is the rate-limiting enzyme in the polyol pathway, and is known to play a key role in the pathogenesis of diabetic complications. 30707979

2019

Entrez Id: 231
Gene Symbol: AKR1B1
AKR1B1
CUI: C0342257
Disease: Complications of Diabetes Mellitus
Complications of Diabetes Mellitus
0.400 Biomarker BEFREE Subtle involvement of ALR2 in invoking various pathways of diabetic complications has caused an increase in attention towards the identification of novel aldose reductase inhibitors (ARIs). 30551523

2019

Entrez Id: 231
Gene Symbol: AKR1B1
AKR1B1
CUI: C0342257
Disease: Complications of Diabetes Mellitus
Complications of Diabetes Mellitus
0.400 Biomarker BEFREE Discovery of 3-[(4,5,7-trifluorobenzothiazol-2-yl)methyl]indole-N-acetic acid (lidorestat) and congeners as highly potent and selective inhibitors of aldose reductase for treatment of chronic diabetic complications. 15857120

2005

Entrez Id: 231
Gene Symbol: AKR1B1
AKR1B1
CUI: C0342257
Disease: Complications of Diabetes Mellitus
Complications of Diabetes Mellitus
0.400 Biomarker BEFREE Aldose Reductase (AR), a polyol pathway enzyme that mediates diabetic complications is implicated in tumour development and progression. 30062975

2018

Entrez Id: 231
Gene Symbol: AKR1B1
AKR1B1
CUI: C0342257
Disease: Complications of Diabetes Mellitus
Complications of Diabetes Mellitus
0.400 Biomarker BEFREE Aldose reductase (ALR2) inhibition is the most legitimate approach for the management of diabetic complications. 28399135

2017

Entrez Id: 231
Gene Symbol: AKR1B1
AKR1B1
CUI: C0342257
Disease: Complications of Diabetes Mellitus
Complications of Diabetes Mellitus
0.400 Biomarker BEFREE The identified protein is designated as RSOR because it is renal-specific with properties of an oxido-reductase, and like ALR2 it may be relevant in the renal complications of diabetes mellitus. 10944187

2000

Entrez Id: 231
Gene Symbol: AKR1B1
AKR1B1
CUI: C0342257
Disease: Complications of Diabetes Mellitus
Complications of Diabetes Mellitus
0.400 Biomarker BEFREE Aldose reductase catalyzes the first step in the polyol pathway and is thought to be involved in the pathogenesis of diabetic complications. 15094999

2004

Entrez Id: 231
Gene Symbol: AKR1B1
AKR1B1
CUI: C0342257
Disease: Complications of Diabetes Mellitus
Complications of Diabetes Mellitus
0.400 AlteredExpression BEFREE The synthetic ARIs are often associated with deleterious side effects and medicinal and edible plants, containing compounds with aldose reductase inhibitory activity, could be useful for prevention and therapy of diabetic complications. 29427593

2018

Entrez Id: 231
Gene Symbol: AKR1B1
AKR1B1
CUI: C0342257
Disease: Complications of Diabetes Mellitus
Complications of Diabetes Mellitus
0.400 Biomarker BEFREE Tolrestat and epalrestat have been characterized as noncompetitive inhibitors of aldo-ketone reductase 1B1 (AKR1B1), a leading drug target for the treatment of type 2 diabetes complications. 31573681

2020

Entrez Id: 231
Gene Symbol: AKR1B1
AKR1B1
CUI: C0342257
Disease: Complications of Diabetes Mellitus
Complications of Diabetes Mellitus
0.400 Biomarker BEFREE As part of our ongoing search for natural sources of therapeutic and preventive agents for diabetic complications, we evaluated the inhibitory effects of components of the fruit of Xanthium strumarium (X. strumarium) on aldose reductase (AR) and galactitol formation in rat lenses with high levels of glucose. 23604720

2013

Entrez Id: 231
Gene Symbol: AKR1B1
AKR1B1
CUI: C0342257
Disease: Complications of Diabetes Mellitus
Complications of Diabetes Mellitus
0.400 Biomarker BEFREE Aldose reductase (AR) is an enzyme devoted to cell detoxification and at the same time is strongly involved in the aetiology of secondary diabetic complications and the amplification of inflammatory phenomena. 28856935

2017

Entrez Id: 231
Gene Symbol: AKR1B1
AKR1B1
CUI: C0342257
Disease: Complications of Diabetes Mellitus
Complications of Diabetes Mellitus
0.400 GeneticVariation BEFREE The N-(aroyl)-N-(arylmethyloxy)-α-alanines are a promising starting point for the development of new ALR2 selective drugs with the aim of delaying the onset of diabetic complications. 28392277

2017

Entrez Id: 231
Gene Symbol: AKR1B1
AKR1B1
CUI: C0342257
Disease: Complications of Diabetes Mellitus
Complications of Diabetes Mellitus
0.400 GeneticVariation BEFREE Glucose over-utilization through the polyol pathway has been linked to tissue-based pathologies associated with diabetes complications, which make the development of a potent aldose reductase inhibitor an obvious and attractive strategy to prevent or delay the onset and progression of the complications. 17497245

2007