Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 2261
Gene Symbol: FGFR3
FGFR3
CUI: C4048328
Disease: cervical cancer
cervical cancer
0.540 Biomarker BEFREE Fibroblast growth factor receptor-3 (FGFR3) is a receptor tyrosine kinase implicated in the tumorigenesis of multiple malignancies, including bladder and other urothelial cancers, multiple myeloma, and cervical cancer. 22285006

2013

Entrez Id: 2261
Gene Symbol: FGFR3
FGFR3
CUI: C4048328
Disease: cervical cancer
cervical cancer
0.540 Biomarker BEFREE The frequency of FGFR3-TACC3-fusion-positive cervical cancer is also 1.9% (2/103) in an independent cohort. 29358619

2018

Entrez Id: 2261
Gene Symbol: FGFR3
FGFR3
CUI: C4048328
Disease: cervical cancer
cervical cancer
0.540 Biomarker BEFREE The research conducted in this article examines a frequently identified fusion protein between FGFR3 and transforming acidic coiled-coil containing protein 3 (TACC3), frequently identified in glioblastoma, lung cancer, bladder cancer, oral cancer, head and neck squamous cell carcinoma, gallbladder cancer, and cervical cancer. 26869289

2016

Entrez Id: 2261
Gene Symbol: FGFR3
FGFR3
CUI: C4048328
Disease: cervical cancer
cervical cancer
0.540 Biomarker BEFREE In this report, we aimed to explore the roles of gene polymorphisms affecting x-ray repair cross complementing 1 (XRCC1), the tumor protein p53 (TP53), and fibroblast growth factor receptor 3 (FGFR3) in the context of susceptibility to cervical cancer. 30616520

2019

Entrez Id: 3115
Gene Symbol: HLA-DPB1
HLA-DPB1
CUI: C4048328
Disease: cervical cancer
cervical cancer
0.500 Biomarker BEFREE These results indicate that HLA-DPB1*1301 may confer susceptibility to cervical cancer, and the haplotypes DRB1*150101-DQB1*0602 and DRB1*070101-DQB1*0201 may contribute to the resistance to the development of cervical cancer among Chinese women. 17349874

2007

Entrez Id: 3115
Gene Symbol: HLA-DPB1
HLA-DPB1
CUI: C4048328
Disease: cervical cancer
cervical cancer
0.500 GeneticVariation BEFREE Additionally, as for the HPV16 E6 prototype-positive cervical cancers, a significant positive association was found in DQB1*060101 allele (OR=5.95; P=0.002; Pc=0.036), and similar trends were observed for DQB1*030201 (OR=10.87, P<0.0001; Pc=0.0018), and DPB1*1301(OR=7.40, P=0.002; Pc=0.04). 17311339

2007

Entrez Id: 6794
Gene Symbol: STK11
STK11
CUI: C4048328
Disease: cervical cancer
cervical cancer
0.500 AlteredExpression BEFREE Thus, homozygous deletions affecting LKB1 in cervical cancers may generate multiple fusion transcripts involving LKB1, SBNO2, and c19orf26. 20193846

2010

Entrez Id: 3115
Gene Symbol: HLA-DPB1
HLA-DPB1
CUI: C4048328
Disease: cervical cancer
cervical cancer
0.500 GeneticVariation BEFREE Our study provides the first systematic investigation of the association of genetic variants in the HLA-DP region with cervical cancer susceptibility and provides further insight into the contribution of polymorphisms in the HLA-DP region to risk of cervical cancer. 24743517

2014

Entrez Id: 3115
Gene Symbol: HLA-DPB1
HLA-DPB1
CUI: C4048328
Disease: cervical cancer
cervical cancer
0.500 GeneticVariation BEFREE We investigated whether polymorphisms in the HLA-DPB1 gene were associated with cervical cancer risk in a Taiwanese population. 26031576

2015

Entrez Id: 3115
Gene Symbol: HLA-DPB1
HLA-DPB1
CUI: C4048328
Disease: cervical cancer
cervical cancer
0.500 GeneticVariation BEFREE D6S2766 and D6S2764, which are located near to the region containing the HLA-DPB genes, were negatively related with cervical cancer (OR for the D6S2766-195 allele carriers = 0.50), and positively related with cervical cancer (OR for the D6S2764-209 allele carriers = 2.44), respectively. 18712835

2008

Entrez Id: 3115
Gene Symbol: HLA-DPB1
HLA-DPB1
CUI: C4048328
Disease: cervical cancer
cervical cancer
0.500 GeneticVariation BEFREE No association was detected between HLA-DPB1 alleles and cervical cancer risk in the Japanese population. 27193219

2016

Entrez Id: 3115
Gene Symbol: HLA-DPB1
HLA-DPB1
CUI: C4048328
Disease: cervical cancer
cervical cancer
0.500 GeneticVariation BEFREE Subgroup analyses based on race system showed that HLA-DPB1⁎13:01 was significantly associated with an increased risk of cervical cancer in Asia (OR=1.834, 95%CI: 1.107-3.039, Pz=0.019). 30009173

2018

Entrez Id: 3115
Gene Symbol: HLA-DPB1
HLA-DPB1
CUI: C4048328
Disease: cervical cancer
cervical cancer
0.500 GeneticVariation BEFREE The results illustrate the value of pathway-based analysis to mine genome-wide data, and point to the importance of the MHC region and specifically the HLA-DPB1 locus for susceptibility to cervical cancer. 21716314

2011

Entrez Id: 6794
Gene Symbol: STK11
STK11
CUI: C4048328
Disease: cervical cancer
cervical cancer
0.500 Biomarker BEFREE Heightened and sustained receptor activation was demonstrated by LKB1-deficient A549 (lung) and HeLaS3 (cervical) cancer cell lines. 24285539

2014

Entrez Id: 3115
Gene Symbol: HLA-DPB1
HLA-DPB1
CUI: C4048328
Disease: cervical cancer
cervical cancer
0.500 GeneticVariation BEFREE The strongest class II effects are coming from the DQB1 and DRB1 loci, but the DPB1 locus also contributes to the susceptibility to cervical cancer. 15238505

2004

Entrez Id: 6794
Gene Symbol: STK11
STK11
CUI: C4048328
Disease: cervical cancer
cervical cancer
0.500 GeneticVariation BEFREE Mutations in the tumor suppressor gene LKB1 are important in hereditary Peutz-Jeghers syndrome, as well as in sporadic cancers including lung and cervical cancer. 21926085

2011

Entrez Id: 6794
Gene Symbol: STK11
STK11
CUI: C4048328
Disease: cervical cancer
cervical cancer
0.500 GeneticVariation BEFREE Somatic LKB1 mutations promote cervical cancer progression. 19340305

2009

Entrez Id: 6794
Gene Symbol: STK11
STK11
CUI: C4048328
Disease: cervical cancer
cervical cancer
0.500 GeneticVariation BEFREE The liver kinase B1 (LKB1) gene is a tumor suppressor associated with the hereditary Peutz-Jeghers syndrome and frequently mutated in non-small cell lung cancer and in cervical cancer. 30222967

2018

Entrez Id: 6794
Gene Symbol: STK11
STK11
CUI: C4048328
Disease: cervical cancer
cervical cancer
0.500 AlteredExpression BEFREE Gene expression profiles of cervical cancer HeLa cells stably expressing LKB1 were analyzed by microarray. 24792998

2014

Entrez Id: 6794
Gene Symbol: STK11
STK11
CUI: C4048328
Disease: cervical cancer
cervical cancer
0.500 Biomarker BEFREE Mir-155 promotes cervical cancer cell proliferation through suppression of its target gene LKB1. 25155037

2014

Entrez Id: 6794
Gene Symbol: STK11
STK11
CUI: C4048328
Disease: cervical cancer
cervical cancer
0.500 AlteredExpression BEFREE LKB1 expression and the integrity of LKB1-AMPK signaling were determined with immunoblot in 6 cervical cancer cell lines. 22735790

2012

Entrez Id: 6794
Gene Symbol: STK11
STK11
CUI: C4048328
Disease: cervical cancer
cervical cancer
0.500 GeneticVariation BEFREE However, the significance of LKB1 mutations in cervical cancer initiation and progress has not been examined. 27546620

2017

Entrez Id: 6794
Gene Symbol: STK11
STK11
CUI: C4048328
Disease: cervical cancer
cervical cancer
0.500 Biomarker BEFREE The LKB1 serine-threonine kinase is a tumor suppressor that is inactivated in a large number of sporadic human lung non-small cell carcinomas (NSCLCs) and cervical cancers. 19724060

2009

Entrez Id: 3115
Gene Symbol: HLA-DPB1
HLA-DPB1
CUI: C4048328
Disease: cervical cancer
cervical cancer
0.500 GeneticVariation BEFREE These findings indicate that HLA-DP rs3077 and rs9277535 were candidate susceptibility markers for cervical cancer in Chinese females. 23428460

2013

Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
CUI: C4048328
Disease: cervical cancer
cervical cancer
0.400 AlteredExpression BEFREE These suggest that overexpressions of MMP-2 and MT1-MMP, loss of TIMP-2 expression, and up-regulation of beta-catenin by AAC-11 transfection may contribute to the development of cervical cancer invasion. 10780674

2000