Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3458
Gene Symbol: IFNG
IFNG
Diabetes Mellitus, Insulin-Dependent
0.600 Biomarker BEFREE Interleukin (IL)-18 is a potent pro-inflammatory cytokine capable of inducing interferon-gamma production that is associated with the development of T1DM. 17373930

2007

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
Diabetes Mellitus, Insulin-Dependent
0.600 Biomarker BEFREE IL-18 and IFN-γ have also been implicated in the onset of different types of immune-mediate inflammatory conditions such as Type 1 Diabetes (T1D), Celiac disease (CD), rheumatoid arthritis (RA), obesity and systemic lupus erythematosus (SLE). 28673589

2017

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
Diabetes Mellitus, Insulin-Dependent
0.600 GeneticVariation BEFREE The aim of this study was to investigate the frequency of a CA dinucleotide repeat polymorphism in the interferon-gamma (IFN-gamma) gene (IFNG) and a C(-590)T polymorphism of the interleukin-4 (IL-4) gene in 236 Caucasoid patients with type 1 diabetes. 10714554

2000

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
Diabetes Mellitus, Insulin-Dependent
0.600 AlteredExpression BEFREE These findings suggest that the increased peripheral B:9-23rPep-specific IFN-γ immunoreactivity reflects decreased functional β-cell mass and greater disease activity of type 1 diabetes. 31525445

2019

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
Diabetes Mellitus, Insulin-Dependent
0.600 AlteredExpression BEFREE On the other hand, higher ketoacidosis at onset, younger age at onset, and higher levels of tumor necrosis factor-alpha and interferon-gamma were observed in T1D patients carriers of G allele in comparison with the carriers of AA genotype. 19136037

2009

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
Diabetes Mellitus, Insulin-Dependent
0.600 Biomarker BEFREE IGRP(265-273)-specific CD8 T-cells that were cloned from the peripheral blood of a recent onset T1D individual were shown to secrete IFNγ and Granzyme B after antigen-specific activation and lyse HLA-A2-expressing murine islets in-vitro. 23155466

2012

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
Diabetes Mellitus, Insulin-Dependent
0.600 GeneticVariation BEFREE Serum levels of the interferon-gamma-inducing cytokine interleukin-18 are increased in individuals at high risk of developing type I diabetes. 11317661

2001

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
Diabetes Mellitus, Insulin-Dependent
0.600 Biomarker BEFREE Pro-inflammatory cytokines, such as interleukin-1β and interferon-γ, secreted by the immune cells invading islets of Langerhans, contribute to pancreatic β-cell death in T1D. 29367588

2018

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
Diabetes Mellitus, Insulin-Dependent
0.600 Biomarker BEFREE The gene encoding interferon (IFN)-gamma, IFNG, is known as one of the candidate susceptibility genes for type 1 diabetes. 15241679

2004

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
Diabetes Mellitus, Insulin-Dependent
0.600 Biomarker RGD The role of endogenous interferon-gamma (IFN gamma) in the development of insulin-dependent diabetes mellitus (IDDM) in diabetes-prone BB rats was evaluated. 8977415

1997

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
Diabetes Mellitus, Insulin-Dependent
0.600 AlteredExpression BEFREE Dominant TCR alpha-chain clonotypes and interferon-gamma are expressed in the pancreas of patients with recent-onset insulin-dependent diabetes mellitus. 8968689

1996

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
Diabetes Mellitus, Insulin-Dependent
0.600 Biomarker MGD IFN-gamma affects homing of diabetogenic T cells. 11714835

2001

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
Diabetes Mellitus, Insulin-Dependent
0.600 GeneticVariation BEFREE Two-thirds of 46 GWAS candidate genes examined were expressed in human islets, and 11 of these significantly changed expression levels following exposure to proinflammatory cytokines (IL-1β + IFNγ + TNFα) for 48 h. Using the GWAS single nucleotide polymorphisms (SNPs) from each locus, we constructed a genetic risk score based on the cumulative number of risk alleles carried in children with newly diagnosed T1D. 26904692

2016

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
Diabetes Mellitus, Insulin-Dependent
0.600 Biomarker BEFREE We studied helper T-lymphocyte reactivity against β-cell autoantigens by measuring production of the pro-inflammatory cytokine interferon-γ and the anti-inflammatory cytokine interleukin-10, using enzyme-linked immunospot assays in 61 people with Type 1 diabetes (within 3 months of diagnosis, positive for HLA DRB1*0301 and/or *0401), of whom 33 were children/adolescents, and a further 91 were unaffected siblings. 27151105

2017

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
Diabetes Mellitus, Insulin-Dependent
0.600 Biomarker BEFREE The increased IFN-gamma response and lower IL-4 response toward diabetes-related autoantigens shown in CTLA-4 +49 GG risk subjects show a possible mechanism for the association between CTLA-4 and T1D. 17659059

2007

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
Diabetes Mellitus, Insulin-Dependent
0.600 AlteredExpression BEFREE The serum levels of IL-2 and IFN-γ were lower in both groups with T1D compared to controls, whilst the level of IL-4 did not differ. 31560963

2019

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
Diabetes Mellitus, Insulin-Dependent
0.600 Biomarker BEFREE These results suggest that the IFN-gamma gene region may contribute to the pathogenesis of IDDM and could be a genetic marker for IDDM. 7867888

1994

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
Diabetes Mellitus, Insulin-Dependent
0.600 Biomarker CTD_human Prevention and treatment of diabetes with resveratrol in a non-obese mouse model of type 1 diabetes. 21340626

2011

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
Diabetes Mellitus, Insulin-Dependent
0.600 AlteredExpression BEFREE Moreover, serum IFN-γ levels were lower in T1D patients compared to controls (p = 0.03) while IL-4 and IL-10 were not different. 29774468

2018

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
Diabetes Mellitus, Insulin-Dependent
0.600 Biomarker BEFREE Type 1 Diabetes (T1D) is an autoimmune disease where local release of cytokines such as IL-1β and IFN-γ contributes to β-cell apoptosis. 24462878

2014

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
Diabetes Mellitus, Insulin-Dependent
0.600 Biomarker BEFREE A high proportion of new-onset T1D subjects mounted an inflammatory IFN-γ response much more frequently to one of the mimotope peptides than to the natural peptide. 25831495

2015

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
Diabetes Mellitus, Insulin-Dependent
0.600 AlteredExpression BEFREE Proinflammatory cytokines (IL-1β and IFN-γ) that mediate β-cell dysfunction in T1D down-regulated HIP14 expression in insulin-secreting INS-1 cells and in isolated rat and human islets. 21705657

2011

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
Diabetes Mellitus, Insulin-Dependent
0.600 Biomarker BEFREE T cells secreting the cytokines IFN-γ and IL-10 in response to seven peptides known to elicit T cell responses in type 1 diabetes were quantified by cytokine ELISPOT in HLA-typed patients characterized for Abs to IA-2 epitopes. 25225671

2014

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
Diabetes Mellitus, Insulin-Dependent
0.600 Biomarker BEFREE Interferon γ plays a critical role in the pathogenesis of type 1 diabetes. 30827273

2019

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
Diabetes Mellitus, Insulin-Dependent
0.600 AlteredExpression BEFREE Similarly, Interferon γ (IFN-γ), and intracellular free Calcium Ion (ifCa2+) levels were increased in T1D MOs than in control MOs, but the difference did not reach a significant level. 31322069

2019