×
Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
Ovarian Carcinoma
0.500
GeneticVariation
BEFREE
Ovarian carcinoma in situ with germline BRCA1 mutation and loss of heterozygosity at BRCA1 and TP53.10880552 2000
×
Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
Ovarian Carcinoma
0.500
Biomarker
BEFREE
BRCA1 is a tumor suppressor gene that is responsible for hereditary breast and ovarian carcinoma syndrome.11443609 2001
×
Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
Ovarian Carcinoma
0.500
Biomarker
BEFREE
BRCA-1 and BRCA-2 are tumor suppressor genes in familial breast-ovarian carcinoma syndrome.11550149 2001
×
Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
Ovarian Carcinoma
0.500
PosttranslationalModification
BEFREE
BRCA1 promoter hypermethylation and protein expression in ovarian carcinoma --an Indian study.24385383 2014
×
Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
Ovarian Carcinoma
0.500
Biomarker
BEFREE
BRCA1 /2 pathogenic (P) and likely pathogenic (LP) germline variants are frequent among patients with ovarian carcinoma .30606148 2019
×
Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
Ovarian Carcinoma
0.500
GeneticVariation
BEFREE
BRCA1 5382insC mutation in sporadic and familial breast and ovarian carcinoma in Scotland.9155062 1997
×
Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
Ovarian Carcinoma
0.500
GeneticVariation
BEFREE
A high proportion of young women with invasive OC have mutations in BRCA1 , and a smaller fraction have mutations in other known OC genes.
26718727 2016
×
Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
Ovarian Carcinoma
0.500
GeneticVariation
BEFREE
A patient with breast carcinoma diagnosed at the age of 30 years and ovarian carcinoma diagnosed at the age of 41 years was found to have germline mutations in both the BRCA1 and the BRCA2 genes.
9790802 1998
×
Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
Ovarian Carcinoma
0.500
Biomarker
BEFREE
Aberrant Promoter Hypermethylation of RASSF1a and BRCA1 in Circulating Cell-Free Tumor DNA Serves as a Biomarker of Ovarian Carcinoma .
31653147 2019
×
Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
Ovarian Carcinoma
0.500
GeneticVariation
BEFREE
Alteration of expression of the tumor suppressor gene BRCA-1 has been widely studied in breast and ovarian carcinoma .
30446260 2019
×
Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
Ovarian Carcinoma
0.500
GeneticVariation
BEFREE
Antitumor activity and safety of the PARP inhibitor rucaparib in patients with high-grade ovarian carcinoma and a germline or somatic BRCA1 or BRCA2 mutation: Integrated analysis of data from Study 10 and ARIEL2.
28882436 2017
×
Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
Ovarian Carcinoma
0.500
GeneticVariation
BEFREE
At the time of salpingo-oophorectomy, five of 58 BRCA1 carriers (8.6%) were diagnosed with an occult carcinoma: two fallopian tube carcinomas, two ovarian carcinomas and one case was defined as a fallopian tube/ovarian carcinoma .
15083174 2004
×
Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
Ovarian Carcinoma
0.500
GeneticVariation
BEFREE
BRCA2 mutations were less common than BRCA1 mutations in families with any history of ovarian carcinoma .
10717622 2000
×
Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
Ovarian Carcinoma
0.500
GeneticVariation
BEFREE
Clinical characteristics and outcomes of patients with BRCA1 or RAD51C methylated versus mutated ovarian carcinoma .
29233532 2018
×
Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
Ovarian Carcinoma
0.500
GeneticVariation
BEFREE
Eligible patients are premenopausal BRCA1 /2 mutation carriers after completing childbearing without (a history of) ovarian carcinoma .
26286255 2015
×
Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
Ovarian Carcinoma
0.500
GeneticVariation
BEFREE
Four carriers of pathogenic mutations in both BRCA1 and BRCA2 were identified among women who underwent genetic counseling for hereditary susceptibility to breast and ovarian carcinoma at three different Italian institutions.
20373018 2010
×
Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
Ovarian Carcinoma
0.500
GeneticVariation
BEFREE
Germ-line mutations in the BRCA1 and BRCA2 genes confer a predisposition to breast as well as ovarian carcinoma .
9661879 1998
×
Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
Ovarian Carcinoma
0.500
GeneticVariation
BEFREE
Germline mutations in the BRCA1 and BRCA2 genes are associated with an inherited predisposition to breast and ovarian carcinoma , and specific mutations in these genes are found at increased frequency in certain populations.
12879478 2003
×
Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
Ovarian Carcinoma
0.500
Biomarker
BEFREE
Here, we show that the p53-related gene p73, encoding a proapoptotic protein that is linked to chemosensitivity in many settings, is upregulated through a novel epigenetic mechanism in both human and murine models of BRCA1 -associated ovarian carcinoma .
20807817 2010
×
Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
Ovarian Carcinoma
0.500
GeneticVariation
BEFREE
In women with breast cancer, mutations in BRCA1 and BRCA2 were associated with a 10-fold increased risk of subsequent ovarian carcinoma (P = .005).
9667259 1998
×
Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
Ovarian Carcinoma
0.500
Biomarker
BEFREE
Increased cell survival by inhibition of BRCA1 using an antisense approach in an estrogen responsive ovarian carcinoma cell line.
11056686 2000
×
Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
Ovarian Carcinoma
0.500
Biomarker
BEFREE
Intraepithelial T cells and prognosis in ovarian carcinoma : novel associations with stage, tumor type, and BRCA1 loss.
19060844 2009
×
Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
Ovarian Carcinoma
0.500
GeneticVariation
BEFREE
It is not yet known how frequently somatic BRCA1 mutations predispose to breast and ovarian carcinoma in the general female population.
8173065 1993
×
Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
Ovarian Carcinoma
0.500
AlteredExpression
BEFREE
Low BRCA1 expression in primary sporadic ovarian carcinoma is associated with prolonged survival.
19602291 2009
×
Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
Ovarian Carcinoma
0.500
Biomarker
BEFREE
Methylation of all BRCA1 copies predicts response to the PARP inhibitor rucaparib in ovarian carcinoma .
30266954 2018